Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

NK CELL RECOGNITION

2004 • 2,685 citations

IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages

2007 • 1,809 citations

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

2008 • 1,801 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

IL-22 Increases the Innate Immunity of Tissues

2004 • 1,330 citations

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

2008 • 1,139 citations

The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes.

1986 • 1,106 citations

Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

2008 • 1,062 citations

ATP drives lamina propria TH17 cell differentiation

2008 • 1,035 citations

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

2008 • 1,014 citations

An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

2003 • 917 citations

IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

2006 • 898 citations

CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity

2003 • 820 citations

Differentiation and function of Th17 T cells

2007 • 720 citations

Organogenesis of lymphoid tissues

2003 • 716 citations

New aspects of natural-killer-cell surveillance and therapy of cancer

2002 • 713 citations

Activation of NK cell cytotoxicity

2004 • 660 citations

Developing Lymph Nodes Collect CD4 + CD3 − LTβ + Cells That Can Differentiate to APC, NK Cells, and Follicular Cells but Not T or B Cells

1997 • 654 citations

Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function

2003 • 598 citations

The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic

2004 • 561 citations

Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1

2006 • 532 citations

Regulation of the Natural Killer Cell Receptor Repertoire

2001 • 531 citations

p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation

1997 • 518 citations

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells

2008 • 509 citations

Thymic Origin of Intestinal αß T Cells Revealed by Fate Mapping of RORγt ⁺ Cells

2004 • 482 citations

Transcriptional regulation of Th17 cell differentiation

2007 • 469 citations

A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127

2006 • 443 citations

Identification, activation, and selectivein vivoablation of mouse NK cells via NKp46

2007 • 442 citations

In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells

2002 • 438 citations

NATURAL KILLER CELL DEVELOPMENTAL PATHWAYS: A Question of Balance

2006 • 432 citations

Developmental pathways that generate natural-killer-cell diversity in mice and humans

2007 • 415 citations

IL-15 is an essential mediator of peripheral NK-cell homeostasis

2003 • 336 citations

Commensal-dependent expression of IL-25 regulates the IL-23–IL-17 axis in the intestine

2008 • 278 citations

Roles for Common Cytokine Receptor γ-Chain-Dependent Cytokines in the Generation, Differentiation, and Maturation of NK Cell Precursors and Peripheral NK Cells in Vivo

2005 • 271 citations

Attaching and effacing locus of a Citrobacter freundii biotype that causes transmissible murine colonic hyperplasia

1993 • 266 citations

Licensing of natural killer cells by self‐major histocompatibility complex class I

2006 • 242 citations

Transcription

2002 • 241 citations

Functional subsets of mouse natural killer cells

2006 • 233 citations

Characteristics of natural killer cells in the murine intestinal epithelium and lamina propria.

1982 • 223 citations

Natural killer and lymphokine-activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells.

1995 • 216 citations

Activation and self‐tolerance of natural killer cells

2006 • 211 citations

Posttranscriptional Regulation of Il10 Gene Expression Allows Natural Killer Cells to Express Immunoregulatory Function

2008 • 163 citations

CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells

2007 • 157 citations

The murine homologue of the human NKp46, a triggering receptor involved in the induction of natural cytotoxicity

1999 • 156 citations

Natural killer cells wear different hats: effector cells of innate resistance and regulatory cells of adaptive immunity and of hematopoiesis

1995 • 154 citations

Mice Lacking T and B Lymphocytes Develop Transient Colitis and Crypt Hyperplasia yet Suffer Impaired Bacterial Clearance during Citrobacter rodentium Infection

2002 • 140 citations

Human small-intestinal epithelium contains functional natural killer lymphocytes

2003 • 110 citations

Regulation of IL-17 production in human lymphocytes

2007 • 104 citations

Intestinal Intraepithelial Lymphocytes Contain a CD3⁻ CD7⁺ Subset Expressing Natural Killer Markers and a Singular Pattern of Adhesion Molecules

2000 • 72 citations

Lymphoid Tissue Inducer Cells in Intestinal Immunity

2006 • 65 citations

From induced to programmed lymphoid tissues: the long road to preempt pathogens

2007 • 32 citations

Unique subset of natural killer cells develops from progenitors in lymph node

2008 • 28 citations