Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR6

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

2005 • 4,573 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2005 • 3,961 citations

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

2003 • 2,856 citations

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

2006 • 2,234 citations

Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s

1998 • 2,048 citations

Development, cytokine profile and function of human interleukin 17–producing helper T cells

2007 • 1,962 citations

Phenotypic and functional features of human Th17 cells

2007 • 1,832 citations

Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

2006 • 1,806 citations

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

2007 • 1,773 citations

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

2007 • 1,772 citations

The lineage decisions of helper T cells

2002 • 1,678 citations

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

2003 • 1,652 citations

Increased expression of interleukin 17 in inflammatory bowel disease

2002 • 1,638 citations

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

1998 • 1,574 citations

TH-17 cells in the circle of immunity and autoimmunity

2007 • 1,520 citations

Inducing and expanding regulatory T cell populations by foreign antigen

2005 • 1,245 citations

Mig and IP-10: CXC chemokines that target lymphocytes

1997 • 802 citations

The Vast Majority of CLA+ T Cells Are Resident in Normal Skin

2006 • 741 citations

TGF-β1 Plays an Important Role in the Mechanism of CD4+CD25+ Regulatory T Cell Activity in Both Humans and Mice

2004 • 643 citations

Up-Regulation of Macrophage Inflammatory Protein-3α/CCL20 and CC Chemokine Receptor 6 in Psoriasis

2000 • 533 citations

CCR6 Mediates Dendritic Cell Localization, Lymphocyte Homeostasis, and Immune Responses in Mucosal Tissue

2000 • 485 citations

Rules of chemokine receptor association with T cell polarization in vivo

2001 • 472 citations

Dendritic Cells Rapidly Recruited into Epithelial Tissues via CCR6/CCL20 Are Responsible for CD8+ T Cell Crosspriming In Vivo

2006 • 366 citations

Bonzo/CXCR6 expression defines type 1–polarized T-cell subsets with extralymphoid tissue homing potential

2001 • 352 citations

CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset

2004 • 314 citations

T-cell homing specificity and plasticity: new concepts and future challenges

2006 • 298 citations

The IL-23/Th17 axis: therapeutic targets for autoimmune inflammation

2006 • 295 citations

Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17

2007 • 293 citations

The Majority of Human Peripheral Blood CD4+CD25highFoxp3+ Regulatory T Cells Bear Functional Skin-Homing Receptors

2006 • 278 citations

T-bet is required for optimal proinflammatory CD4+ T-cell trafficking

2005 • 260 citations

T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17

2006 • 259 citations

Generation of gut‐homing T cells and their localization to the small intestinal mucosa

2007 • 248 citations

CCR6-Mediated Dendritic Cell Activation of Pathogen-Specific T Cells in Peyer's Patches

2006 • 245 citations

Transcription

2002 • 241 citations

Enhancing Effect of IL-1, IL-17, and TNF-α on Macrophage Inflammatory Protein-3α Production in Rheumatoid Arthritis: Regulation by Soluble Receptors and Th2 Cytokines

2001 • 231 citations

Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease

2006 • 229 citations

CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses

2001 • 218 citations

Divergent Effects of Interleukin-4 and Interferon-γ on Macrophage-Derived Chemokine Production: An Amplification Circuit of Polarized T Helper 2 Responses

1998 • 203 citations

Differential expression of the chemokine receptors by the Th1- and Th2-type effect or populations within circulating CD4+ T cells

2000 • 182 citations

Characterization of Human T Cells That Regulate Neutrophilic Skin Inflammation

2004 • 163 citations

Development, trafficking, and function of memory T‐cell subsets

2006 • 153 citations

Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP-3alpha) production in normal colon and inflammatory bowel disease

2002 • 148 citations

Neutrophils produce biologically active macrophage inflammatory protein-3α (MIP-3α) / CCL20 and MIP-3β / CCL19

2001 • 146 citations

Requirement for the Chemokine Receptor Ccr6 in Allergic Pulmonary Inflammation

2001 • 140 citations

Cutting Edge: Human Th17 Cells Are Identified as Bearing CCR2+CCR5− Phenotype

2007 • 133 citations

Expression of CCR6 and CD83 by cytokine-activated human neutrophils

2000 • 118 citations

Genetic Reprogramming of Primary Human T Cells Reveals Functional Plasticity in Th Cell Differentiation

2003 • 112 citations

Cutting Edge: C-C Chemokine Receptor 6 Is Essential for Arrest of a Subset of Memory T Cells on Activated Dermal Microvascular Endothelial Cells Under Physiologic Flow Conditions In Vitro

2000 • 111 citations

Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6.

1999 • 104 citations

Phenotype and Effector Function of CC Chemokine Receptor 9-Expressing Lymphocytes in Small Intestinal Crohn’s Disease

2007 • 91 citations

Cutting Edge: Immature Dendritic Cells Generated from Monocytes in the Presence of TGF-β1 Express Functional C-C Chemokine Receptor 6

1999 • 89 citations

CCR6 has a non‐redundant role in the development of inflammatory bowel disease

2003 • 88 citations

CCR6 regulates CD4+ T-cell–mediated acute graft-versus-host disease responses

2005 • 87 citations

MIP-3α neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inflammation in mice

2007 • 63 citations

Plasma Cell-Like Morphology of Th1-Cytokine-Producing Cells Associated with the Loss of CD3 Expression

2004 • 56 citations

CD3⁺ WT31⁻ peripheral T lymphocytes lack T44 (CD28), a surface molecule involved in activation of T cells bearing the α/β heterodimer

1987 • 50 citations

Functional characterization of two S-nitroso-<scp>l</scp>-cysteine transporters, which mediate movement of NO equivalents into vascular cells

2006 • 45 citations

Protective immunity and delayed type hypersensitivity reaction are uncoupled in experimental Leishmania major infection of CCR6-negative mice

2006 • 17 citations

The IL-23/Th17 axis: therapeutic targets for autoimmune inflammation [Current Opinion in Immunology 2006, 18:670–675]

2006 • 16 citations