Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

Atopic Dermatitis

2000 • 4,717 citations

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

2005 • 4,165 citations

Transforming growth factor-β induces development of the TH17 lineage

2006 • 3,014 citations

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

2006 • 2,234 citations

Phenotypic and functional features of human Th17 cells

2007 • 1,832 citations

Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

2006 • 1,806 citations

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

1999 • 1,660 citations

Pathogenesis and therapy of psoriasis

2007 • 1,652 citations

Increased expression of interleukin 17 in inflammatory bowel disease

2002 • 1,638 citations

IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis

2006 • 1,520 citations

TH-17 cells in the circle of immunity and autoimmunity

2007 • 1,520 citations

IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6

2006 • 1,510 citations

Suppression of Immune Induction of Collagen-Induced Arthritis in IL-17-Deficient Mice

2003 • 1,280 citations

TNF/iNOS-Producing Dendritic Cells Mediate Innate Immune Defense against Bacterial Infection

2003 • 1,129 citations

Antigen-Specific T Cell Sensitization Is Impaired in IL-17-Deficient Mice, Causing Suppression of Allergic Cellular and Humoral Responses

2002 • 1,063 citations

Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial

2005 • 1,024 citations

A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis

2006 • 987 citations

IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

2006 • 898 citations

Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris

2004 • 873 citations

Serum Levels of TNF‐α, IFN‐γ, IL‐6, IL‐8,IL‐12, IL‐17, and IL‐18 in Patients With Active Psoriasis andCorrelation With Disease Severity

2005 • 757 citations

A global phase III randomized controlled trial of etanercept in psoriasis: safety, efficacy, and effect of dose reduction

2005 • 686 citations

Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway

2001 • 601 citations

Interleukin-17 and Interferon-γ Synergize in the Enhancement of Proinflammatory Cytokine Production by Human Keratinocytes

1998 • 565 citations

The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis

2007 • 478 citations

Tumor Necrosis Factor Inhibitors for Rheumatoid Arthritis

2006 • 466 citations

In Vitro and In Situ Expression of IL-23 by Keratinocytes in Healthy Skin and Psoriasis Lesions: Enhanced Expression in Psoriatic Skin

2006 • 442 citations

IL-17 Markedly Up-Regulates β-Defensin-2 Expression in Human Airway Epithelium via JAK and NF-κB Signaling Pathways

2004 • 410 citations

Expression of interleukin‐22 in rheumatoid arthritis: Potential role as a proinflammatory cytokine

2005 • 397 citations

Immunopathogenic mechanisms in psoriasis

2003 • 382 citations

TNF Inhibition Rapidly Down-Regulates Multiple Proinflammatory Pathways in Psoriasis Plaques

2005 • 370 citations

Antitumor Monoclonal Antibodies Enhance Cross-Presentation of Cellular Antigens and the Generation of Myeloma-specific Killer T Cells by Dendritic Cells

2002 • 355 citations

Novel mechanisms of T-cell and dendritic cell activation revealed by profiling of psoriasis on the 63,100-element oligonucleotide array

2003 • 298 citations

Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17

2007 • 293 citations

Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages

2007 • 287 citations

α1β1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis

2007 • 256 citations

Upregulation of Interleukin-12 and -17 in Active Inflammatory Bowel Disease

2003 • 240 citations

Tumor Necrosis Factor Antagonists: Different Kinetics and/or Mechanisms of Action May Explain Differences in the Risk for Developing Granulomatous Infection

2006 • 232 citations

Alefacept reduces infiltrating T cells, activated dendritic cells, and inflammatory genes in psoriasis vulgaris

2005 • 220 citations

Adalimumab induces apoptosis of human monocytes: a comparative study with infliximab and etanercept

2005 • 218 citations

Autoimmunity and Anti-TNF-α Agents

2005 • 154 citations

T cell clones from psoriasis skin lesions can promote keratinocyte proliferation in vitro via secreted products

1994 • 152 citations

Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease

2006 • 152 citations

IL‐23 up‐regulates IL‐10 and induces IL‐17 synthesis by polyclonally activated naive T cells in human

2005 • 143 citations

Development of an anti‐IL‐17A auto‐vaccine that prevents experimental auto‐immune encephalomyelitis

2006 • 142 citations

Efalizumab (anti-CD11a)-induced increase in peripheral blood leukocytes in psoriasis patients is preferentially mediated by altered trafficking of memory CD8+ T cells into lesional skin

2004 • 72 citations

Psoriasis genomics: analysis of proinflammatory (type 1) gene expression in large plaque (Western) and small plaque (Asian) psoriasis vulgaris

2004 • 67 citations

Etanercept induces apoptosis of dermal dendritic cells in psoriatic plaques of responding patients

2006 • 59 citations

New concepts in the pathogenesis and treatment of psoriasis: key roles for IL-23, IL-17A and TGF-β₁

2007 • 48 citations

The expression of interleukin-17, interferon-gamma, and macrophage inflammatory protein-3 alpha mRNA in patients with psoriasis vulgaris

2004 • 47 citations

A Statistically Valid Alternative to the TDT

2002 • 20 citations