Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Integrins

2002 • 8,127 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand

2002 • 1,571 citations

Crystal Structure of the Extracellular Segment of Integrin αVβ3

2001 • 1,256 citations

Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling

2002 • 1,134 citations

Structural Basis of Collagen Recognition by Integrin α2β1

2000 • 945 citations

Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18)

1995 • 893 citations

Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins.

1998 • 834 citations

Breaking the Integrin Hinge

1996 • 567 citations

A reevaluation of integrins as regulators of angiogenesis

2002 • 546 citations

Conformational Regulation of Integrin Structure and Function

2002 • 536 citations

Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation

2003 • 518 citations

A Structural Mechanism of Integrin αIIbβ3 “Inside-Out” Activation as Regulated by Its Cytoplasmic Face

2002 • 511 citations

Structural Determinants of Integrin Recognition by Talin

2003 • 505 citations

Site-directed mutagenesis of the cell-binding domain of human fibronectin: Separable, synergistic sites mediate adhesive function

1988 • 372 citations

Regulation of Integrin α5β1-Fibronectin Interactions by Divalent Cations

1995 • 325 citations

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

2002 • 313 citations

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.

1995 • 308 citations

Integrin activation takes shape

2002 • 299 citations

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain 1 1Edited by F. E. Cohen

1999 • 255 citations

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1.

2001 • 255 citations

A mechanism for divalent cation regulation of beta 3-integrins.

1994 • 196 citations

Coming to grips with integrin binding to ligands

2002 • 190 citations

Mechanisms contributing to the activity of integrins on leukocytes

2002 • 181 citations

Epitope Mapping of Antibodies to the C-Terminal Region of the Integrin β2 Subunit Reveals Regions that Become Exposed Upon Receptor Activation

2001 • 161 citations

Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains

2001 • 160 citations

Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

1997 • 160 citations

An Isoleucine-based Allosteric Switch Controls Affinity and Shape Shifting in Integrin CD11b A-domain

2000 • 142 citations

Integrin Structure

2000 • 132 citations

An isolated, surface-expressed I domain of the integrin αLβ2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond

2001 • 129 citations

Integrin Activation Involves a Conformational Change in the α1 Helix of the β Subunit A-domain

2002 • 128 citations

Conformational Changes in the Integrin औA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

2003 • 120 citations

NMR Analysis of Structure and Dynamics of the Cytosolic Tails of Integrin αIIbβ3 in Aqueous Solution

2001 • 117 citations

Genetic analysis of β1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules

1997 • 109 citations

Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin α5β1

1998 • 99 citations

Differential regulation of Rho GTPases by β1 and β3 integrins: the role of an extracellular domain of integrin in intracellular signaling

2002 • 97 citations

Structural and Functional Studies with Antibodies to the Integrin β2 Subunit

2000 • 96 citations

Molecular Basis of Ligand Recognition by Integrin α5β1

2000 • 95 citations

Effects of Ligand-Mimetic Peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on αIIbβ3 Integrin Conformation and Oligomerization

1999 • 87 citations

Molecular Basis of Ligand Recognition by Integrin α5β1

2000 • 71 citations

The Eighth FIII Domain of Human Fibronectin Promotes Integrin α5β1 Binding via Stabilization of the Ninth FIII Domain

2001 • 68 citations

Integrin cell adhesion receptors and the concept of agonism

2000 • 58 citations

Probing Chemical and Conformational Differences in the Resting and Active Conformers of Platelet Integrin αIIbβ3

2000 • 55 citations

Fine mapping of inhibitory anti-α5 monoclonal antibody epitopes that differentially affect integrin–ligand binding

1999 • 53 citations

Agonist-specific Structural Rearrangements of Integrin αIIbβ3

2002 • 37 citations

Predicted and experimental structures of integrins and β-propellers

2002 • 36 citations

Fine mapping of inhibitory anti-α5 monoclonal antibody epitopes that differentially affect integrin‒ligand binding

1999 • 14 citations