CPSF recognition of an HIV-1 mRNA 3'-processing enhancer: multiple sequence contacts involved in poly(A) site definition.

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites

1992 • 466 citations

THE BIOCHEMISTRY OF 3′-END CLEAVAGE AND POLYADENYLATION OF MESSENGER RNA PRECURSORS

1992 • 387 citations

In vitro polyadenylation is stimulated by the presence of an upstream intron.

1990 • 313 citations

Definition of an efficient synthetic poly(A) site.

1989 • 285 citations

A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs.

1990 • 243 citations

The 64-kilodalton subunit of the CstF polyadenylation factor binds to pre-mRNAs downstream of the cleavage site and influences cleavage site location.

1994 • 236 citations

Assembly of a processive messenger RNA polyadenylation complex.

1993 • 223 citations

Four factors are required for 3'-end cleavage of pre-mRNAs.

1989 • 217 citations

Cleavage and polyadenylation factor CPF specifically interacts with the pre-mRNA 3′ processing signal AAUAAA.

1991 • 207 citations

Efficiency of Utilization of the Simian Virus 40 Late Polyadenylation Site: Effects of Upstream Sequences

1989 • 205 citations

An ordered pathway of assembly of components required for polyadenylation site recognition and processing.

1989 • 194 citations

Purification of the cleavage and polyadenylation factor involved in the 3'-processing of messenger RNA precursors.

1991 • 172 citations

Characterization of the multisubunit cleavage-polyadenylation specificity factor from calf thymus.

1992 • 170 citations

Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B viruses.

1990 • 159 citations

Direct interaction of the U1 snRNP-A protein with the upstream efficiency element of the SV40 late polyadenylation signal.

1994 • 146 citations

Poly(A) site efficiency reflects the stability of complex formation involving the downstream element.

1991 • 140 citations

The human immunodeficiency virus type 1 polyadenylylation signal: a 3' long terminal repeat element upstream of the AAUAAA necessary for efficient polyadenylylation.

1991 • 136 citations

Isolation and expression of cDNA clones encoding mammalian poly(A) polymerase.

1991 • 129 citations

Nuclear polyadenylation factors recognize cytoplasmic polyadenylation elements.

1994 • 125 citations

Messenger RNA3' End Formation in Plants

1994 • 120 citations

Two proteins crosslinked to RNA containing the adenovirus L3 poly(A) site require the AAUAAA sequence for binding.

1988 • 111 citations

Molecular analyses of two poly(A) site-processing factors that determine the recognition and efficiency of cleavage of the pre-mRNA.

1991 • 111 citations

Sequences upstream of AAUAAA influence poly(A) site selection in a complex transcription unit.

1989 • 108 citations

Poly(A) polymerase purified from HeLa cell nuclear extract is required for both cleavage and polyadenylation of pre-mRNA in vitro.

1989 • 104 citations

Upstream introns influence the efficiency of final intron removal and RNA 3'-end formation.

1994 • 101 citations

Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences

1991 • 90 citations

Sequences Within the Last Intron function in RNA 3'-End Formation in Cultured Cells

1993 • 88 citations

Activation of HIV-1 pre-mRNA 3′ processing in vitro requires both an upstream element and TAR.

1992 • 87 citations

Definition of the Upstream Efficiency Element of the Simian Virus 40 Late Polyadenylation Signal by Using In Vitro Analyses

1992 • 81 citations

Involvement of long terminal repeat U3 sequences overlapping the transcription control region in human immunodeficiency virus type 1 mRNA 3' end formation.

1991 • 79 citations

Elements upstream of the AAUAAA within the human immunodeficiency virus polyadenylation signal are required for efficient polyadenylation in vitro.

1992 • 73 citations

Regulation of polyadenylation in human immunodeficiency virus (HIV): contributions of promoter proximity and upstream sequences.

1992 • 72 citations

Occlusion of the HIV poly(A) site.

1991 • 68 citations

Site-directed ribose methylation identifies 2′-OH groups in polyadenylation substrates critical for AAUAAA recognition and poly(A) addition

1991 • 67 citations

Signals that produce 3' termini in CYC1 mRNA of the yeast Saccharomyces cerevisiae.

1993 • 67 citations

Multiple factors are required for poly(A) addition to a mRNA 3' end.

1988 • 65 citations

Splice site selection dominates over poly(A) site choice in RNA production from complex adenovirus transcription units.

1988 • 64 citations

Regulation of polyadenylation in hepatitis B viruses: stimulation by the upstream activating signal PS1 is orientation-dependent, distance-independent, and additive

1991 • 59 citations

Alternative poly(A) site utilization during adenovirus infection coincides with a decrease in the activity of a poly(A) site processing factor.

1993 • 54 citations

Varied poly(A) site efficiency in the adenovirus major late transcription unit.

1992 • 42 citations

Upstream sequences and cap proximity in the regulation of polyadenylation in ground squirrel hepatitis virus

1992 • 42 citations

Sequence elements upstream of the 3' cleavage site confer substrate strength to the adenovirus L1 and L3 polyadenylation sites.

1994 • 40 citations

Polyadenylation of mRNA: minimal substrates and a requirement for the 2' hydroxyl of the U in AAUAAA.

1990 • 35 citations

Sequences regulating temporal poly(A) site switching in the adenovirus major late transcription unit.

1991 • 33 citations

Sequence signals which may be required for efficient formation of mRNA 3' termini

1986 • 30 citations

Upstream and downstream c/s-acting elements for cleavage at the L4 polyadenylation site of adenovirus-2

1994 • 26 citations

Developmental Regulation of Secreted and Membrane Forms of Immunoglobulin μ Chain

1989 • 16 citations

Analysis of the 5′-AAUAAA motif and its flanking sequence in human RNA: relevance to cDNA library sorting

1992 • 11 citations

Sequence Elements Upstream of the 3′ Cleavage Site Confer Substrate Strength to the Adenovirus L1 and L3 Polyadenylation Sites

1994 • 6 citations