Upstream introns influence the efficiency of final intron removal and RNA 3'-end formation.

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

Exon definition may facilitate splice site selection in RNAs with multiple exons.

1990 • 726 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.

1988 • 539 citations

Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein

1991 • 433 citations

Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm

1989 • 417 citations

THE BIOCHEMISTRY OF 3′-END CLEAVAGE AND POLYADENYLATION OF MESSENGER RNA PRECURSORS

1992 • 387 citations

A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II.

1988 • 370 citations

Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing

1992 • 367 citations

The role of exon sequences in splice site selection.

1993 • 367 citations

Accurate cleavage and polyadenylation of exogenous RNA substrate

1985 • 334 citations

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.

1990 • 322 citations

In vitro polyadenylation is stimulated by the presence of an upstream intron.

1990 • 313 citations

Intervening sequences increase efficiency of RNA 3' processing and accumulation of cytoplasmic RNA

1990 • 312 citations

Sex-specific splicing and polyadenylation of dsx pre-mRNA requires a sequence that binds specifically to tra-2 protein in vitro

1991 • 244 citations

Alpha-thalassaemia caused by a poly(A) site mutation reveals that transcriptional termination is linked to 3′ end processing in the human alpha 2 globin gene.

1986 • 236 citations

Adenovirus tripartite leader sequence enhances translation of mRNAs late after infection.

1984 • 234 citations

U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exon.

1992 • 225 citations

Selection of splice sites in pre-mRNAs with short internal exons.

1991 • 224 citations

Site-specific polyadenylation in a cell-free reaction

1984 • 223 citations

Mature mRNA 3′ end formation stimulates RNA export from the nucleus.

1991 • 222 citations

Effect of 5' splice site mutations on splicing of the preceding intron.

1990 • 200 citations

Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.

1993 • 200 citations

Mutation of the AAUAAA polyadenylation signal depresses in vitro splicing of proximal but not distal introns.

1991 • 200 citations

Scanning and competition between AGs are involved in 3' splice site selection in mammalian introns.

1993 • 194 citations

Regulation of doublesex pre-mRNA processing occurs by 3'-splice site activation.

1991 • 184 citations

Binding of the Drosophila transformer and transformer-2 proteins to the regulatory elements of doublesex primary transcript for sex-specific RNA processing.

1992 • 168 citations

Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA.

1990 • 159 citations

Are vertebrate exons scanned during splice-site selection?

1992 • 141 citations

Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product.

1992 • 135 citations

Evidence for an essential non-Watson–Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron

1993 • 133 citations

Association with terminal exons in pre-mRNAs: a new role for the U1 snRNP?

1993 • 121 citations

Simian virus 40 late transcripts lacking excisable intervening sequences are defective in both stability in the nucleus and transport to the cytoplasm

1989 • 102 citations

Splicing Precedes Polyadenylation during Drosophila E74A Transcription

1990 • 100 citations

Splice site choice and splicing efficiency are positively influenced by pre-mRNA intramolecular base pairing in yeast

1993 • 94 citations

Sequences Within the Last Intron function in RNA 3'-End Formation in Cultured Cells

1993 • 88 citations

Unexpected point mutations activate cryptic 3' splice sites by perturbing a natural secondary structure within a yeast intron.

1991 • 81 citations

Introns excised from the Delta primary transcript are localized near sites of Delta transcription.

1992 • 81 citations

Definition of the Upstream Efficiency Element of the Simian Virus 40 Late Polyadenylation Signal by Using In Vitro Analyses

1992 • 81 citations

Introns in histone genes alter the distribution of 3′ ends

1990 • 73 citations

3' RNA processing efficiency plays a primary role in generating termination-competent RNA polymerase II elongation complexes.

1993 • 71 citations

Direct selection for mutations affecting specific splice sites in a hamster dihydrofolate reductase minigene.

1993 • 55 citations

Characterization of the mouse beta maj globin transcription termination region: a spacing sequence is required between the poly(A) signal sequence and multiple downstream termination elements.

1993 • 52 citations

Simian virus 40 late mRNA leader sequences involved in augmenting mRNA accumulation via multiple mechanisms, including increased polyadenylation efficiency

1991 • 49 citations

In vivo cooperation between introns during pre-mRNA processing.

1993 • 37 citations

Polyadenylation precedes splicing in vitro.

1991 • 33 citations

Revving up gene expression

1989 • 23 citations