Regulation of polyadenylation in human immunodeficiency virus (HIV): contributions of promoter proximity and upstream sequences.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

3′ Non-coding region sequences in eukaryotic messenger RNA

1976 • 3,001 citations

The sequence 5′-AAUAAA-3′ forms part of the recognition site for polyadenylation of late SV40 mRNAs

1981 • 819 citations

The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini

1985 • 652 citations

Role of the Conserved AAUAAA Sequence: Four AAUAAA Point Mutants Prevent Messenger RNA 3′ End Formation

1984 • 561 citations

Efficient infection of monkey cells with DNA of simian virus 40.

1981 • 419 citations

α-Thalassaemia caused by a polyadenylation signal mutation

1983 • 407 citations

Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity

1990 • 351 citations

Definition of an efficient synthetic poly(A) site.

1989 • 285 citations

Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAA

1983 • 278 citations

Requirement of a downstream sequence for generation of a poly(A) addition site

1984 • 261 citations

A sequence downstream of AAUAAA is required for rabbit β-globin mRNA 3′-end formation

1984 • 251 citations

Efficiency of Utilization of the Simian Virus 40 Late Polyadenylation Site: Effects of Upstream Sequences

1989 • 205 citations

Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B viruses.

1990 • 159 citations

Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.

1990 • 151 citations

The AAUAAA sequence is required both for cleavage and for polyadenylation of simian virus 40 pre-mRNA in vitro.

1986 • 147 citations

Construction of a modular dihydrofolate reductase cDNA gene: analysis of signals utilized for efficient expression.

1982 • 145 citations

A sequence downstream of A-A-U-A-A-A is required for formation of simian virus 40 late mRNA 3' termini in frog oocytes.

1985 • 139 citations

The human immunodeficiency virus type 1 polyadenylylation signal: a 3' long terminal repeat element upstream of the AAUAAA necessary for efficient polyadenylylation.

1991 • 136 citations

A cis-acting element within the 5′ leader of a cytomegalovirus β transcript determines kinetic class

1986 • 125 citations

Regulation of HIV-1 Gene Expression

1990 • 122 citations

Sequences upstream of AAUAAA influence poly(A) site selection in a complex transcription unit.

1989 • 108 citations

A dissection of the cauliflower mosaic virus polyadenylation signal.

1991 • 105 citations

Definition of essential sequences and functional equivalence of elements downstream of the adenovirus E2A and the early simian virus 40 polyadenylation sites.

1985 • 102 citations

Proximity to the promoter inhibits recognition of cauliflower mosaic virus polyadenylation signal

1990 • 94 citations

Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences

1991 • 90 citations

Involvement of long terminal repeat U3 sequences overlapping the transcription control region in human immunodeficiency virus type 1 mRNA 3' end formation.

1991 • 79 citations

Analysis of mRNA 3′ end formation by modification interference: the only modifications which prevent processing lie in AAUAAA and the poly(A) site.

1987 • 77 citations

The AAUAAA Sequence Is Required both for Cleavage and for Polyadenylation of Simian Virus 40 Pre-mRNA In Vitro

1986 • 69 citations

Occlusion of the HIV poly(A) site.

1991 • 68 citations

A functionally redundant downstream sequence in SV40 late pre-mRNA is required for mRNA 3'-end formation and for assembly of a precleavage complex in vitro.

1988 • 64 citations

Sequences Upstream of AAUAAA Influence Poly(A) Site Selection in a Complex Transcription Unit

1989 • 54 citations

Identification of a U5-specific sequence required for efficient polyadenylation within the human immunodeficiency virus long terminal repeat

1989 • 52 citations

Definition of Essential Sequences and Functional Equivalence of Elements Downstream of the Adenovirus E2A and the Early Simian Virus 40 Polyadenylation Sites

1985 • 51 citations

Construction of a Modular Dihydrofolate Reductase cDNA Gene: Analysis of Signals Utilized for Efficient Expression

1982 • 51 citations

Site-Directed Mutagenesis of the SH2- and SH3-Coding Domains of c-src Produces Varied Phenotypes, Including Oncogenic Activation of p60^c-src

1990 • 47 citations

The efficiency of RNA 3'-end formation is determined by the distance between the cap site and the poly(A) site in spleen necrosis virus.

1990 • 45 citations

Replication of duck hepatitis B virus in two differentiated human hepatoma cell lines after transfection with cloned viral DNA

1988 • 44 citations

Involvement of Long Terminal Repeat U3 Sequences Overlapping the Transcription Control Region in Human Immunodeficiency Virus Type 1 mRNA 3′ End Formation

1991 • 43 citations

Kinetics and efficiency of polyadenylation of late polyomavirus nuclear RNA: generation of oligomeric polyadenylated RNAs and their processing into mRNA.

1984 • 42 citations

Mutations in poly(A) site downstream elements affect in vitro cleavage activity.

1988 • 28 citations

Kinetics and Efficiency of Polyadenylation of Late Polyomavirus Nuclear RNA: Generation of Oligomeric Polyadenylated RNAs and Their Processing into mRNA

1984 • 25 citations

Mutations in Poly(A) Site Downstream Elements Affect In Vitro Cleavage Activity

1988 • 15 citations