Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

1999 • 1,912 citations

Requirement for IL-13 Independently of IL-4 in Experimental Asthma

1998 • 1,869 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

IMMUNOLOGIC BASIS OF ANTIGEN-INDUCED AIRWAY HYPERRESPONSIVENESS

1999 • 1,047 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6

1997 • 921 citations

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

1997 • 815 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Allergic and Nonallergic Asthmatics Have Distinct Patterns of T-Cell Activation and Cytokine Production in Peripheral Blood and Bronchoalveolar Lavage

1992 • 788 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

1997 • 666 citations

YERSINIA ENTEROCOLITICA INFECTIONS AND PORK: THE MISSING LINK

1987 • 654 citations

Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice

1989 • 635 citations

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

1995 • 619 citations

Transcription factor GATA-3 is required for development of the T-cell lineage

1996 • 614 citations

Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma.

1998 • 557 citations

Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity

1998 • 480 citations

Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.

1993 • 479 citations

Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production

1997 • 464 citations

Cutting Edge: Modulation of Airway Inflammation by CpG Oligodeoxynucleotides in a Murine Model of Asthma

1998 • 416 citations

Infection of Mice with Mycobacterium bovis–Bacillus Calmette-Guérin (BCG) Suppresses Allergen-induced Airway Eosinophilia

1998 • 404 citations

Long Term Prevention of Allergic Lung Inflammation in a Mouse Model of Asthma by CpG Oligodeoxynucleotides

1999 • 392 citations

The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

1999 • 377 citations

Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

1991 • 364 citations

CD4⁺T-Lymphocytes and Interleukin-5 Mediate Antigen-induced Eosinophil Infiltration into the Mouse Trachea

1992 • 353 citations

T LYMPHOCYTE ACTIVATION IN ACUTE SEVERE ASTHMA

1988 • 353 citations

Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3

1999 • 333 citations

Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma

1997 • 321 citations

T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma.

1996 • 309 citations

Prednisolone Treatment in Asthma Is Associated with Modulation of Bronchoalveolar Lavage Cell Interleukin-4, Interleukin-5, and Interferon-γ Cytokine Gene Expression

1993 • 307 citations

Essential Role of Nuclear Factor κB in the Induction of Eosinophilia in Allergic Airway Inflammation

1998 • 304 citations

IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells.

1998 • 296 citations

Requirement for γδ T Cells in Allergic Airway Inflammation

1998 • 268 citations

Elevated Release of Tumor Necrosis Factor-alpha and Interferon-gamma by Bronchoalveolar Leukocytes from Patients with Bronchial Asthma

1993 • 262 citations

Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils.

1999 • 244 citations

T Helper 1 Cells and Interferon γ Regulate Allergic Airway Inflammation and Mucus Production

1999 • 243 citations

Cutting Edge: IL-4-Independent Induction of Airway Hyperresponsiveness by Th2, But Not Th1, Cells

1998 • 234 citations

Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3.

1998 • 228 citations

Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells.

1987 • 209 citations

GATA-3-dependent enhancer activity in IL-4 gene regulation.

1998 • 205 citations

Gene expression of the GATA-3 transcription factor is increased in atopic asthma

1999 • 204 citations

Differences between IL-4Rα-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses

1998 • 204 citations

Th2-Induced Airway Mucus Production Is Dependent on IL-4Rα, But Not on Eosinophils

1999 • 192 citations

A potential vaccine strategy for asthma and allied atopic diseases during early childhood

1994 • 182 citations

Distinct functional phenotypes of cloned Ia-restricted helper T cells.

1985 • 171 citations

Transcription Factors in Lymphocyte Development— T and B Cells Get Together

1999 • 169 citations

Hematopoiesis: how does it happen?

1995 • 169 citations

Cutting Edge: Differential Responsiveness of the IL-5 and IL-4 Genes to Transcription Factor GATA-3

1998 • 162 citations

Cutting Edge: GATA-3-Dependent Enhancer Activity in IL-4 Gene Regulation

1998 • 158 citations

T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6

1998 • 148 citations

Mast cells modulate allergic pulmonary eosinophilia in mice.

1995 • 147 citations

Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus.

1996 • 145 citations

Activation of the Interleukin-5 Promoter by cAMP in Murine EL-4 Cells Requires the GATA-3 and CLE0 Elements

1995 • 137 citations

Interleukin-13 and interleukin-4 are coexpressed in atopic asthma.

1996 • 113 citations

IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma c chain.

1996 • 109 citations

Regulation of T helper cell differentiation by STAT molecules

1998 • 107 citations

Genetic Regulation of Commitment to Interleukin 4 Production by a CD4+ T Cell–intrinsic Mechanism

1998 • 104 citations

The one-two of T helper cells: does interferon-gamma knock out the Th2 hypothesis for asthma?

1996 • 85 citations

The Effect of Segmental Bronchoprovocation with Allergen on Airway Lymphocyte Function

1997 • 74 citations

The Stability and Reversibility of Th1 and Th2 Populations

1999 • 60 citations

Specific V beta T cell subsets mediate the immediate hypersensitivity response to ragweed allergen.

1993 • 53 citations

Abnormal cytokine expression in Sézary and adult T-cell leukemia cells correlates with the functional diversity between these T-cell malignancies.

1994 • 44 citations

Do Allergens Induce Type–2 Immune Responses?

1999 • 9 citations