The Angiopoietins: Yin and Yang in Angiogenesis

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Requirement for neuregulin receptor erbB2 in neural and cardiac development

1995 • 1,272 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1995 • 1,108 citations

Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.

1994 • 979 citations

Pericytes in the microvasculature

1996 • 726 citations

Ligands for EPH-Related Receptor Tyrosine Kinases that Require Membrane Attachment or Clustering for Activity

1994 • 720 citations

The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases

1995 • 704 citations

Differentiation of endothelium

1995 • 617 citations

Endothelial receptor tyrosine kinases involved in angiogenesis.

1995 • 537 citations

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

1995 • 517 citations

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.

1993 • 470 citations

How does extracellular matrix control capillary morphogenesis?

1989 • 466 citations

The role of vascular endothelial growth factor in pathological angiogenesis

1995 • 419 citations

tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.

1992 • 410 citations

Vascular system defects and neuronal apoptosis in mice lacking Ras GTPase-activating protein

1995 • 368 citations

A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.

1992 • 351 citations

Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization.

1995 • 338 citations

Expression of tie-2, a member of a novel family of receptor tyrosine kinases, in the endothelial cell lineage

1993 • 275 citations

Intussusceptive Microvascular Growth in a Human Colon Adenocarcinoma Xenograft: A Novel Mechanism of Tumor Angiogenesis

1996 • 258 citations

Stimulation and inhibition of angiogenesis by placental proliferin and proliferin-related protein

1994 • 244 citations

Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development.

1996 • 228 citations

Molecular Cloning and Characterization of Mouse TIE and TEK Receptor Tyrosine Kinase Genes and Their Expression in Hematopoietic Stem Cells

1993 • 224 citations

DEVELOPMENT OF THE VASCULAR SYSTEM

1983 • 207 citations

Development of the Vascular System

2014 • 134 citations

Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family.

1993 • 129 citations

Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta.

1993 • 107 citations

The Regulation of Blood Vessel Growth by Vascular Endothelial Growth Factor

1995 • 95 citations

Implementation of Intussusceptive Microvascular Growth in the Chicken Chorioallantoic Membrane (CAM):

1996 • 93 citations

The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells

1996 • 81 citations

Predominant expression of a receptor tyrosine kinase, TIE, in hematopoietic stem cells and B cells

1996 • 68 citations

Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells.

1996 • 58 citations

Predominant expression of a receptor tyrosine kinase, TIE, in hematopoietic stem cells and B cells

1996 • 56 citations