The von Hippel-Lindau Tumor Suppressor Gene Product Interacts with Sp1 To Repress Vascular Endothelial Growth Factor Promoter Activity

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene

1993 • 2,906 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Current Protocols in Molecular Biology

1989 • 1,916 citations

Mutations of the VHL tumour suppressor gene in renal carcinoma

1994 • 1,719 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells

1995 • 1,001 citations

Clinical Features and Natural History of von Hippel-Lindau Disease

1990 • 916 citations

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.

1996 • 886 citations

Tumour suppression by the human von Hippel-Lindau gene product

1995 • 705 citations

Sp1-mediated transcriptional activation is repressed by Sp3.

1994 • 692 citations

GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

1990 • 677 citations

Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

1995 • 672 citations

Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein

1995 • 571 citations

Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas.

1993 • 564 citations

Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: Correlations with phenotype

1995 • 552 citations

Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.

1996 • 541 citations

Developmental Expression of Sp1 in the Mouse

1991 • 533 citations

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.

1993 • 531 citations

Functional Synergy and Physical Interactions of the Erythroid Transcription Factor GATA-1 with the Krüppel Family Proteins Sp1 and EKLF

1995 • 475 citations

Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression.

1995 • 409 citations

Identification of intragenic mutations in the Von Hippel — Lindau disease tumour suppressor gene andcorrelation with disease phenotype

1994 • 386 citations

Somatic mutations of the von Hippel — Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma

1994 • 371 citations

Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis

1994 • 354 citations

Induction of Vascular Endothelial Growth Factor Gene Expression by Interleukin-1 β in Rat Aortic Smooth Muscle Cells

1995 • 347 citations

Interaction of Sp1 with the Growth- and Cell Cycle-Regulated Transcription Factor E2F

1996 • 343 citations

Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas.

1995 • 329 citations

Elongin (SIII): A Multisubunit Regulator of Elongation by RNA Polymerase II

1995 • 320 citations

Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein.

1996 • 315 citations

Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site.

1994 • 311 citations

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

1991 • 311 citations

Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1.

1993 • 310 citations

Interaction between transcription factors Spl and YY1

1993 • 282 citations

Induction of Vascular Endothelial Growth Factor by Insulin-like Growth Factor 1 in Colorectal Carcinoma

1996 • 272 citations

Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.

1988 • 271 citations

Cell Cycle-Regulated Association of E2F1 and Sp1 Is Related to Their Functional Interaction

1996 • 268 citations

An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation.

1994 • 238 citations

Sp1 Is Phosphorylated and Its DNA Binding Activity Down-regulated upon Terminal Differentiation of the Liver

1995 • 210 citations

Detection and characterization of cellular EGR-1 binding to its recognition site

1993 • 193 citations

Identification of Newly Transcribed <scp>RNA</scp>

2007 • 192 citations

The Retinoblastoma Gene Product RB Stimulates Spl-Mediated Transcription by Liberating Spl from a Negative Regulator

1994 • 189 citations

Purification and analysis of RNA polymerase II transcription factors by using wheat germ agglutinin affinity chromatography.

1989 • 175 citations

Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations.

1995 • 154 citations

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.

1995 • 153 citations

Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1.

1993 • 151 citations

Functional significance of an overlapping consensus binding motif for Sp1 and Zif268 in the murine adenosine deaminase gene promoter.

1991 • 132 citations

Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter.

1991 • 131 citations

Negative regulation of Sp1 trans-activation is correlated with the binding of cellular proteins to the amino terminus of the Sp1 trans-activation domain.

1994 • 128 citations

Bombyx EcR (BmEcR) and Bombyx USP (BmCF1) combine to form a functional ecdysone receptor

1996 • 127 citations

Enhanced expression of c-myc and epidermal growth factor receptor (C-erbB-1) genes in primary human renal cancer.

1988 • 126 citations

SV40 stimulates expression of the transacting factor Sp1 at the mRNA level.

1990 • 124 citations

Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product.

1996 • 120 citations

Sp1 Is a Critical Regulator of the Wilms' tumor-1 Gene

1997 • 103 citations

Association of p107 with Sp1: Genetically Separable Regions of p107 Are Involved in Regulation of E2F- and Sp1-Dependent Transcription

1995 • 98 citations

p53 and Sp1 Interact and Cooperate in the Tumor Necrosis Factor-induced Transcriptional Activation of the HIV-1 Long Terminal Repeat

1995 • 97 citations

Overlapping Pit-1 and Sp1 binding sites are both essential to full rat growth hormone gene promoter activity despite mutually exclusive Pit-1 and Sp1 binding.

1990 • 92 citations

Induction of low density lipoprotein receptor and a transcription factor SP-1 by tumor necrosis factor in human microvascular endothelial cells.

1992 • 90 citations

Transcriptional Regulation of the Elastin Gene by Insulin-like Growth Factor-I Involves Disruption of Sp1 Binding

1995 • 86 citations

Inverse relationship of epidermal growth factor receptor and HER2/neu gene expression in human renal cell carcinoma.

1990 • 77 citations

T3 receptor suppression of Sp1-dependent transcription from the epidermal growth factor receptor promoter via overlapping DNA-binding sites

1993 • 74 citations

Repression of Activator-Mediated Transcription by Herpes Simplex Virus ICP4 via a Mechanism Involving Interactions with the Basal Transcription Factors TATA-Binding Protein and TFIIB

1995 • 66 citations

The level of a transcription factor Sp1 is correlated with the expression of EGF receptor in human gastric carcinomas

1992 • 64 citations

Contributory effects of de novo transcription and premature transcript termination in the regulation of human epidermal growth factor receptor proto-oncogene RNA synthesis

1991 • 58 citations

Liver-enriched Transcription Factor HNF-4 and Ubiquitous Factor NF-Y Are Critical for Expression of Blood Coagulation Factor X

1996 • 53 citations

Herpes simplex virus infected cell polypeptide 4 preferentially represses Sp1-activated over basal transcription from its own promoter.

1993 • 53 citations

Expression of the Von Hippel-Lindau Tumor Suppressor Gene, VHL, in Human Fetal Kidney and During Mouse Embryogenesis

1995 • 52 citations

Transcriptional stimulation of the delta 1-crystallin gene by insulin-like growth factor I and insulin requires DNA cis elements in chicken.

1990 • 47 citations

v-Raf activates transcription of growth-responsive promoters via GC-rich sequences that bind the transcription factor Sp1.

1995 • 46 citations

Increased DNA binding and transcriptional activity associated with transcription factor Sp1 in K562 cells transfected with the myeloid-specific c-fes tyrosine kinase gene

1991 • 38 citations

The v-Rel oncoprotein increases expression from Sp1 site-containing promoters in chicken embryo fibroblasts.

1993 • 34 citations

G10BP, an E1A-Inducible Negative Regulator of Sp1, Represses Transcription of the Rat Fibronectin Gene

1995 • 33 citations

A Unique Thyroid Hormone Response Element in the Human Immunodeficiency Virus Type 1 Long Terminal Repeat That Overlaps the Sp1 Binding Sites

1995 • 27 citations

Purifying nascent mRNA from nuclear run-on assays using guanidinium isothiocyanate.

1993 • 26 citations

Translation initiation in Drosophila melanogaster is reduced by mutations upstream of the AUG initiator codon.

1991 • 25 citations