Humanization of a mouse monoclonal antibody that blocks the epidermal growth factor receptor: recovery of antagonistic activity

Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity

1962 • 6,970 citations

Sequences of proteins of immunological interest

1984 • 3,427 citations

[68] Transcription maps of polyoma virus-specific RNA: Analysis by two-dimensional nuclease S1 gel mapping

1980 • 1,430 citations

Conformations of immunoglobulin hypervariable regions

1989 • 1,165 citations

Anatomy of the antibody molecule

1994 • 868 citations

Antibody framework residues affecting the conformation of the hypervariable loops

1992 • 507 citations

EPIDERMAL-GROWTH-FACTOR RECEPTORS AND OESTROGEN RECEPTORS IN HUMAN BREAST CANCER

1985 • 496 citations

Prediction of immunodominant helper T cell antigenic sites from the primary sequence.

1987 • 483 citations

Growth Inhibition of Human Tumor Cells in Athymic Mice by Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies

1984 • 443 citations

Structure, function and properties of antibody binding sites

1991 • 426 citations

High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines.

1986 • 370 citations

Phase I and Imaging Trial of Indium 111-Labeled Anti-Epidermal Growth Factor Receptor Monoclonal Antibody 225 in Patients With Squamous Cell Lung Carcinoma

1991 • 299 citations

Efficacy of Antibodies to Epidermal Growth Factor Receptor Against KB Carcinoma In Vitro and in Nude Mice

1988 • 240 citations

Conformational sampling using high‐temperature molecular dynamics

1990 • 216 citations

ATTEMPTS TO LOCATE COMPLEMENTARITY‐DETERMINING RESIDUES IN THE VARIABLE POSITIONS OF LIGHT AND HEAVY CHAINS *

1971 • 212 citations

Humanization of a mouse monoclonal antibody by CDR–grafting: the importance of framework residues on loop conformation

1991 • 193 citations

Epidermal growth factor receptors in human breast cancer

1984 • 190 citations

Reshaping a Human Monoclonal Antibody to Inhibit Human Respiratory Syncytial Virus Infection in Vivo

1991 • 162 citations

Malignant astrocytomas treated with iodine-125 labeled monoclonal antibody 425 against epidermal growth factor receptor: A phase II trial

1992 • 147 citations

The epidermal growth factor receptor as a target for therapy in breast carcinoma

1994 • 134 citations

Three-dimensional structure of murine anti-p-azophenylarsonate Fab 36-71. 1. X-ray crystallography, site-directed mutagenesis, and modeling of the complex with hapten

1991 • 80 citations

Immunotherapy of human tumour xenografts overexpressing the EGF receptor with rat antibodies that block growth factor-receptor interaction

1993 • 67 citations

A new monoclonal antibody for detection of EGF‐receptors in western blots and paraffin‐embedded tissue sections

1992 • 56 citations

mRNA Expression of Transforming Growth Factor Alpha in Human Breast Carcinomas and Its Activity in Effusions of Breast Cancer Patients

1989 • 42 citations

Transforming growth factor alpha in human mammary carcinomas and their metastases.

1989 • 20 citations

Are we all out of Africa?

1986 • 14 citations