The Yeast hnRNP-like Protein Hrp1/Nab4 Marks a Transcript for Nonsense-Mediated mRNA Decay

Conserved Structures and Diversity of Functions of RNA-Binding Proteins

1994 • 1,873 citations

A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance

1998 • 1,090 citations

A Perfect Message

1999 • 807 citations

Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

1988 • 684 citations

INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS

1996 • 653 citations

When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.

1995 • 515 citations

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.

1991 • 487 citations

A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm

1998 • 476 citations

mRNA surveillance by the Caenorhabditis elegans smg genes.

1993 • 459 citations

Binary specification of nonsense codons by splicing and cytoplasmic translation

1998 • 396 citations

The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

1998 • 341 citations

Gene products that promote mRNA turnover in Saccharomyces cerevisiae.

1992 • 330 citations

[11] DNA of Saccharomyces cerevisiae

1991 • 308 citations

mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor.

1993 • 307 citations

Intron function in the nonsense-mediated decay of β-globin mRNA: Indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm

1998 • 297 citations

Arginine methylation facilitates the nuclear export of hnRNP proteins

1998 • 287 citations

Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.

1995 • 279 citations

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen.

1995 • 278 citations

A splicing-dependent regulatory mechanism that detects translation signals.

1996 • 278 citations

AUF1 Binding Affinity to A+U-rich Elements Correlates with Rapid mRNA Degradation

1996 • 258 citations

Mutations affecting stability and deadenylation of the yeast MFA2 transcript.

1992 • 228 citations

Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3′-end formation in yeast

1997 • 225 citations

Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.

1993 • 200 citations

A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes.

1995 • 192 citations

Purification and characterization of the Upf1 protein: a factor involved in translation and mRNA degradation.

1995 • 184 citations

Cytoplasmic regulatory functions of the KH-domain proteins hnRNPs K and E1/E2

1998 • 167 citations

RNA14 and RNA15 Proteins as Components of a Yeast Pre-mRNA 3′-End Processing Factor

1994 • 161 citations

Identification and Characterization of Mutations in the UPF1 Gene That Affect Nonsense Suppression and the Formation of the Upf Protein Complex but Not mRNA Turnover

1996 • 152 citations

Characterization of cis-Acting Sequences and Decay Intermediates Involved in Nonsense-Mediated mRNA Turnover

1995 • 146 citations

Identification of AUF1 (Heterogeneous Nuclear Ribonucleoprotein D) as a Component of the α-Globin mRNA Stability Complex

1997 • 146 citations

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein

1997 • 144 citations

Identification and Characterization of a Sequence Motif Involved in Nonsense-Mediated mRNA Decay

1995 • 135 citations

Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae.

1994 • 133 citations

Introns are cis Effectors of the Nonsense-Codon-Mediated Reduction in Nuclear mRNA Abundance

1994 • 131 citations

Mammalian orthologues of a yeast regulator of nonsense transcript stability.

1996 • 129 citations

Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA

1998 • 127 citations

Sequences that surround the stop codons of upstream open reading frames in GCN4 mRNA determine their distinct functions in translational control.

1989 • 121 citations

Modulation of AUUUA Response Element Binding by Heterogeneous Nuclear Ribonucleoprotein A1 in Human T Lymphocytes

1997 • 111 citations

mRNA surveillance in eukaryotes: Kinetic proofreading of proper translation termination as assessed by mRNP domain organization?

1999 • 111 citations

Control of cleavage site selection during mRNA 3' end formation by a yeast hnRNP

1998 • 101 citations

Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover

1999 • 100 citations

Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance.

1994 • 96 citations

Potential RNA Binding Proteins in Saccharomyces cerevisiae Identified as Suppressors of Temperature-Sensitive Mutations in NPL3

1996 • 91 citations

Purification of the Saccharomyces cerevisiae Cleavage/Polyadenylation Factor I

1996 • 89 citations

A mutation in the tRNA nucleotidyltransferase gene promotes stabilization of mRNAs in Saccharomyces cerevisiae.

1992 • 87 citations

The Mof2/Sui1 Protein Is a General Monitor of Translational Accuracy

1998 • 75 citations

Intron-independent Association of Splicing Factors with Active Genes

1999 • 75 citations

Mof4-1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and −1 ribosomal frameshifting efficiency.

1996 • 62 citations

Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense-mediated mRNA decay.

1996 • 49 citations

Mutations in the MOF2/SUI1 gene affect both translation and nonsense-mediated mRNA decay

1999 • 39 citations

The Upf3 protein is a component of the surveillance complex that monitors both translation and mRNA turnover and affects viral propagation

1998 • 37 citations