β-Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon

Translational control of gene expression

2000 • 1,371 citations

Translational control of gene expression

2001 • 1,192 citations

A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance

1998 • 1,090 citations

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.

1990 • 322 citations

Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening.

1994 • 290 citations

The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling

2002 • 283 citations

Unstable β-globin mRNA in mRNA-deficient β0 thalassemia

1981 • 267 citations

The human β-globin gene contains a downstream developmental specific enhancer

1987 • 167 citations

The Yeast hnRNP-like Protein Hrp1/Nab4 Marks a Transcript for Nonsense-Mediated mRNA Decay

2000 • 154 citations

Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

1994 • 140 citations

mRNA metabolism and post-transcriptional gene regulation

1997 • 129 citations

Nonsense Codons in Human β-Globin mRNA Result in the Production of mRNA Degradation Products

1992 • 118 citations

Degradation of apolipoprotein II mRNA occurs via endonucleolytic cleavage at 5′-AAU-3′/5′-UAA-3′ elements in single-stranded loop domains of the 3′-noncoding region

1989 • 118 citations

beta-globin dominant control region interacts differently with distal and proximal promoter elements.

1990 • 112 citations

mRNA-deficint β^°-thaladssemia results from a single nucleotide deletion

1982 • 111 citations

Nonsense mutations in the human β-globin gene lead to unexpected levels of cytoplasmic mRNA accumulation

2000 • 93 citations

Human beta-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates lacking regions of exon I or exons I and II that have a cap-like structure at the 5′ termini.

1992 • 90 citations

Vigilin binding selectively inhibits cleavage of the vitellogenin mRNA 3′-untranslated region by the mRNA endonuclease polysomal ribonuclease 1

2000 • 88 citations

Identification of an erythroid-enriched endoribonuclease activity involved in specific mRNA cleavage

2000 • 84 citations

Nuclease activity associated with mammalian mRNA in its native state: possible basis for selectivity in mRNA decay.

1990 • 81 citations

Purification and Characterization of a Polysome-associated Endoribonuclease That Degrades c-myc mRNA in Vitro

1998 • 70 citations

Purification and Characterization of an Estrogen-regulated Xenopus Liver Polysomal Nuclease Involved in the Selective Destabilization of Albumin mRNA

1995 • 65 citations

Turnover and Translation of in Vitro Synthesized Messenger RNAs in Transfected, Normal Cells

1996 • 61 citations

Novel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice.

1989 • 56 citations

Site-specific cleavage of IGF-II mRNAs requires sequence elements from two distinct regions of the IGF-II gene

1992 • 51 citations

A polysomal ribonuclease involved in the destabilization of albumin mRNA is a novel member of the peroxidase gene family

1998 • 51 citations

Induction of Erythroid-Specific Expression in Murine Erythroleukemia (MEL) Cell Lines

2003 • 48 citations

Mammalian Nonsense Codons Can Be cis Effectors of Nuclear mRNA Half-Life

1994 • 44 citations

Cleavage properties of an estrogen-regulated polysomal ribonuclease involved in the destabilization of albumin mRNA

1997 • 43 citations

Polysomal ribonuclease 1 exists in a latent form on polysomes prior to estrogen activation of mRNA decay

2001 • 36 citations

Identification of in Vivo mRNA Decay Intermediates Corresponding to Sites of in Vitro Cleavage by Polysomal Ribonuclease 1

2001 • 30 citations

Characterization of mRNA Endonucleases

1999 • 25 citations

Comparative analyses of the secondary structures of synthetic and intracellular yeast MFA 2 mRNAs

1998 • 22 citations

Nuclease Activity Associated with Mammalian mRNA in Its Native State: Possible Basis for Selectivity in mRNA Decay

1990 • 8 citations

Nonsense mutations in the human β-globin gene lead to unexpected levels of cytoplasmic mRNA accumulation

2000 • 3 citations