The biology of radioresistance: similarities, differences and interactions with drug resistance

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Elevated recombination rates in transcriptionally active DNA

1989 • 1,666 citations

Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene

1987 • 1,235 citations

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

1985 • 1,233 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

1991 • 708 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

X-ray induced DNA double strand break production and repair in mammalian cells as measured by neutral filter elution

1979 • 577 citations

The scid mutation in mice causes a general defect in DNA repair

1990 • 525 citations

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

1991 • 509 citations

Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation.

1989 • 473 citations

Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum‐Golgi complex

1992 • 461 citations

V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

1992 • 449 citations

Overview: Purinergic Mechanisms

1990 • 408 citations

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange.

1990 • 403 citations

X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining

1984 • 379 citations

The multidrug resistance (mdr1) gene product functions as an ATP channel.

1993 • 372 citations

The ras Oncogenes Increase the Intrinsic Resistance of NIH 3T3 Cells to Ionizing Radiation

1988 • 361 citations

Extracellular ATP as a trigger for apoptosis or programmed cell death.

1991 • 342 citations

A link between double-strand break-related repair and V(D)J recombination: the scid mutation.

1991 • 295 citations

Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism?

1991 • 284 citations

Protein kinase C mediates x-ray inducibility of nuclear signal transducers EGR1 and JUN.

1991 • 277 citations

X-Ray Sensitivity and DNA Synthesis in Synchronous Populations of HeLa Cells

1963 • 259 citations

p53 Functions as a Cell Cycle Control Protein in Osteosarcomas

1990 • 224 citations

The production and repair of double strand breaks in cells from normal humans and from patients with ataxia telangiectasia

1977 • 203 citations

Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man

1987 • 200 citations

DNA Double Strand Breaks in Ehrlich Ascites Tumour Cells at Low Doses of X-rays. II. Can Cell Death be Attributed to Double Strand Breaks?

1982 • 200 citations

Induction of DNA double-strand breaks by X-rays in a radiosensitive strain of the yeast Saccharomyces cerevisiae

1975 • 199 citations

Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity

1992 • 198 citations

Ionizing radiation stimulates unidentified tyrosine-specific protein kinases in human B-lymphocyte precursors, triggering apoptosis and clonogenic cell death.

1992 • 195 citations

Effect of Antisense c- raf -1 on Tumorigenicity and Radiation Sensitivity of a Human Squamous Carcinoma

1989 • 189 citations

Ataxia Telangiectasia: Genetics, Neuropathology, and Immunology of a Degenerative Disease of Childhood

1987 • 187 citations

Studies on mammalian mutants defective in rejoining double-strand breaks in DNA

1990 • 178 citations

The Repair of Double-Strand DNA Breaks Correlates with Radiosensitivity of L5178Y-S and L5178Y-R Cells

1987 • 177 citations

Synergistic effect of the v-myc oncogene with H-ras on radioresistance.

1990 • 174 citations

Identification and characterization of X-ray-induced proteins in human cells.

1989 • 166 citations

P2 purinoceptors on vascular endotheliai cells: physiological significance and transduction mechanisms

1990 • 160 citations

Biological Consequences of Gene Regulation After Ionizing Radiation Exposure

1991 • 160 citations

Mechanisms and consequences of DNA damage processing

1987 • 152 citations

Cell cycle-dependent repair of double-strand DNA breaks in a ?-ray-sensitive Chinese hamster cell

1985 • 150 citations

The raf Oncogene Is Associated with a Radiation-Resistant Human Laryngeal Cancer

1987 • 150 citations

The role of the H-ras oncogene in radiation resistance and metastasis

1990 • 145 citations

Chemical, Oncogene and Growth Factor Inhibition of Gap Junctional Intercellular Communication: An Integrative Hypothesis of Carcinogenesis

1990 • 145 citations

Tumor necrosis factor gene expression is mediated by protein kinase C following activation by ionizing radiation.

1991 • 138 citations

Increased G 2 Delay in Radiation-Resistant Cells Obtained by Transformation of Primary Rat Embryo Cells with the Oncogenes H-ras and v-myc

1991 • 135 citations

The rejoining of double-strand breaks in DNA by human cell extracts

1990 • 135 citations

Cloning and sequence analysis of the Saccharomyces cerevisiae RAD9 gene and further evidence that its product is required for cell cycle arrest induced by DNA damage.

1989 • 134 citations

Treatment of human tumor cells with ADP or ATP yields arrest of growth in the S phase of the cell cycle

1983 • 133 citations

Faster repair of DNA double-strand breaks in radioresistant human tumor cells

1988 • 132 citations

Repair of intrinsic DNA lesions

1990 • 126 citations

Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals

1988 • 125 citations

Tyrosine phosphorylation is a mandatory proximal step in radiation-induced activation of the protein kinase C signaling pathway in human B-lymphocyte precursors.

1993 • 123 citations

Induction and Rejoining of DNA Double-Strand Breaks in Human Cervix Carcinoma Cell Lines of Differing Radiosensitivity

1988 • 115 citations

A ninth complementation group in xeroderma pigmentosum, XP I

1985 • 110 citations

DNA Double-strand Breaks: Their Repair and Relationship to Cell Killing in Yeast

1990 • 104 citations

Genetic analysis of ionising radiation sensitive mutants of cultured mammalian cell lines

1991 • 91 citations

Inhibition of Protein Kinases Sensitizes Human Tumor Cells to Ionizing Radiation

1992 • 91 citations

Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells.

1993 • 88 citations

Characterization of an X-ray-hypersensitive mutant of V79 Chinese hamster cells

1988 • 83 citations

Viral Probes for DNA Repair

1983 • 82 citations

Altered regulation of intercellular communication by epidermal growth factor, transforming growth factor-β and peptide hormones in normal human keratinocytes

1989 • 80 citations

Molecular Cloning of the Human XRCC1 Gene, Which Corrects Defective DNA Strand Break Repair and Sister Chromatid Exchange

1990 • 80 citations

The genetic basis of resistance to ionising radiation damage in cultured mammalian cells

1991 • 72 citations

Cell-cycle-specific repair of DNA double strand breaks in Saccharomyces cerevisiae.

1980 • 71 citations

Tests of the Double-Strand-Break Repair Model for Red-Mediated Recombination of Phage Λ and Plasmid Λdv

1987 • 66 citations

DNA-binding protein activated by gamma radiation in human cells.

1990 • 65 citations

Growth and Radiation Survival Characteristics of V79-171b Chinese Hamster Cells: A Possible Influence of Intercellular Contact

1973 • 63 citations

Multiple components are involved in the effecient joining of double stranded DNA breaks in human cell extracts

1992 • 62 citations

Production of platelet-derived endothelial cell growth factor by normal and transformed human cells in culture.

1989 • 60 citations

RafInvolvement in the Simultaneous Genetic Transfer of the Radioresistant and Transforming Phenotypes

1989 • 59 citations

Gene recombination in X-ray-sensitive hamster cells.

1987 • 58 citations

Cell-Cycle-Specific Repair of DNA Double-Strand Breaks in Saccharomyces cerevisiae

1980 • 57 citations

Six complementation groups for ionising-radiation sensitivity in Chinese hamster cells

1988 • 55 citations

Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant.

1990 • 54 citations

Is the multidrug resistance an ATP channel? Abraham EH, Prat AG, Gerweck L, Seneveratne T, Arceci RJ, Kramer R, Guidotti G, Cantiello HF. The multidrug resistance (mdr1) gene product functions as an ATP channel. Proc Natl Acad Sci USA 1993;90: 312–316

1993 • 54 citations

Recombination and ligation of transfected DNA in CHO mutant EM9, which has high levels of sister chromatid exchange.

1987 • 51 citations

Cytogenetic characterization of the ionizing radiation-sensitive Chinese hamster mutant irs1

1991 • 50 citations

Sequestration and Release of Basic Fibroblast Growth Factor^a

1991 • 48 citations

Ataxia telangiectasia: An investigation of the repair defect in the cell line AT5BIVA by plasmid reconstitution

1993 • 45 citations

Examination of vectors with two dominant, selectable genes for DNA repair and mutation studies in mammalian cells

1988 • 44 citations

Mechanisms of X-ray-mediated protooncogene c-iun expression in radiation-induced human sarcoma cell lines

1991 • 40 citations

Caffeine overcomes a restriction point associated with DNA replication, but does not accelerate mitosis.

1990 • 39 citations

Vector-mediated DNA double-strand break repair analysis in normal, and radiation-sensitive, Chinese hamster V79 cells

1988 • 37 citations

Cloning and Sequence Analysis of the Saccharomyces cerevisiae RAD9 Gene and Further Evidence that Its Product Is Required for Cell Cycle Arrest Induced by DNA Damage

1989 • 36 citations

Interactions between antitumour agents and radiation and the expression of resistance

1991 • 36 citations

Reduction of Radiation-Induced Cell Cycle Blocks by Caffeine Does Not Necessarily Lead to Increased Cell Killing

1991 • 36 citations

Adenine nucleotides modulate phosphatidylcholine metabolism in aortic endothelial cells

1990 • 35 citations

Complementation analysis of ataxia-telangiectasia.

1985 • 32 citations

Lack of Correlation between Radiosensitivity and Inhibition of DNA Synthesis in Hybrids (A-T × HeLa)

1989 • 32 citations

Differential repair of UV damage in Saccharomyces cerevisiae is cell cycle dependent.

1990 • 30 citations

Covalent linkage between nucleotides and platelet-derived endothelial cell growth factor.

1991 • 30 citations

A DNA repair defect in a radiation-sensitive clone of a human bladder carcinoma cell line

1992 • 29 citations

Host cell reactivation by human cells of DNA expression vectors damaged by ultraviolet radiation or by acid-heat treatment

1986 • 29 citations

Dominant Expression of Multiple Drug Resistance After In Vitro X-irradiation Exposure in Intraspecific Chinese Hamster Ovary Hybrid Cells

1993 • 26 citations

P₂-Purinergic Receptors in Vascular Endothelial Cells: from Concept to Reality

1988 • 25 citations

Relative frequencies of homologous recombination between plasmids introduced into DNA repair-deficient and other mammalian somatic cell lines

1990 • 23 citations

Site-Specific Integration of H- ras in Transformed Rat Embryo Cells

1988 • 23 citations

Ecto-phosphorylation on aortic endothelial cells. Exquisite sensitivity to staurosporine

1992 • 22 citations

Decreased Repair of Gamma-irradiated Adenovirus inXeroderma PigmentosumFibroblasts

1979 • 22 citations

Clonal variation of DNA repair in a human glioma cell line

1991 • 22 citations

Role of transfection and clonal selection in mediating radioresistance.

1991 • 22 citations

Effect of Caffeine on the Expression of a Major X-Ray-Induced Protein in Human Tumor Cells

1991 • 20 citations

Basic fibroblast growth factor is a substrate for phosphorylation by human neutrophil ecto-protein kinase activity

1991 • 19 citations

Repair of double-strand breaks in plasmid DNA in the yeast Saccharomyces cerevisiae

1988 • 19 citations

Transformation depending on intermolecular homologous recombination is stimulated by UV damage in transfected DNA

1988 • 17 citations

Analysis of recombination in mammalian cells using SV40 and SV40-derived vectors

1989 • 9 citations

DNA repair in human cells: from genetic complementation to isolation of genes.

1988 • 9 citations

Recombination and Ligation of Transfected DNA in CHO Mutant EM9, Which has High Levels of Sister Chromatid Exchange

1987 • 8 citations

DNA-Binding Protein Activated by Gamma Radiation in Human Cells

1990 • 8 citations

Host cell reactivation of uv- and X-ray-damaged herpes simplex virus by epstein-barr virus (EBV)-transformed lymphoblastoid cell lines

1981 • 7 citations

Basic Fibroblast Growth Factor Is Phosphorylated by an Ecto‐Protein Kinase Associated with the Surface of SK‐Hep Cells

1991 • 3 citations

Control of Prostacyclin Production by Vascular Cells : Role of Adenine Nucleotides and Serotonin

1988 • 2 citations

Human tumor cell repair fidelity correlates with radioresistance

1992 • 1 citations

[Repair of a double-stranded gap in plasmid DNA in radiosensitive mutants of Saccharomyces cerevisiae: effectiveness and precision].

1989 • 1 citations