Vector-mediated DNA double-strand break repair analysis in normal, and radiation-sensitive, Chinese hamster V79 cells

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

Properties of a supercoiled deoxyribonucleic acid-protein relaxation complex and strand specificity of the relaxation event

1970 • 770 citations

The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control

1976 • 518 citations

Mapping temperature-sensitive and host-range mutations of adenovirus type 5 by marker rescue

1978 • 408 citations

X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining

1984 • 379 citations

Enzymatic Restriction of Mammalian Cell DNA Using Pvu II and Bam H1: Evidence for the Double-strand Break Origin of Chromosomal Aberrations

1984 • 313 citations

Molecular mechanisms involved in the production of chromosomal aberrations

1984 • 303 citations

Molecular mechanisms involved in the production of cromosomal aberrations II. Utilization of neurospora endonuclease for the study of aberration production by X-rays in G1 and G2 stages of the cell cycle

1980 • 280 citations

Evidence for DNA Double-Strand Breaks as the Critical Lesions in Yeast Cells Irradiated with Sparsely or Densely Ionizing Radiation under Oxic or Anoxic Conditions

1981 • 271 citations

Sites and structure of gamma radiation-induced DNA strand breaks.

1982 • 249 citations

Radiation-Induced Strand Breaks in DNA: Chemical and Enzymatic Analysis of End Groups and Mechanistic Aspects

1981 • 230 citations

EFFECTS OF THE RAD52 GENE ON RECOMBINATION IN SACCHAROMYCES CEREVISIAE

1980 • 220 citations

The nature of mutants induced by ionising radiation in cultured hamster cells III. Molecular characterization of HPRT-deficient mutants induced by γ-rays or α-particles showing that the majority have deletions of all or part of the hprt gene

1986 • 207 citations

Isolation and cross-sensitivity of X-ray-sensitive mutants of V79-4 hamster cells

1987 • 207 citations

DNA Double Strand Breaks in Ehrlich Ascites Tumour Cells at Low Doses of X-rays. II. Can Cell Death be Attributed to Double Strand Breaks?

1982 • 200 citations

One pyrimidine dimer inactivates expression of a transfected gene in xeroderma pigmentosum cells.

1985 • 189 citations

Somatic Cells Efficiently Join Unrelated DNA Segments End-to-End

1982 • 186 citations

Repair of DNA double-strand breaks in Escherichia coli K12 requires a functional recN product

1984 • 162 citations

Cell cycle-dependent repair of double-strand DNA breaks in a ?-ray-sensitive Chinese hamster cell

1985 • 150 citations

X-ray-induced Chromosome Damage in Live Mammalian Cells, and Improved Measurements of Its Effects on Their Colony-forming Ability

1982 • 135 citations

A New Selective Agent for Eukaryotic Cloning Vectors

1980 • 131 citations

Effectiveness of 1·5 keV Aluminium K and 0·3 keV Carbon K Characteristic X-rays at Inducing DNA Double-strand Breaks in Yeast Cells

1986 • 98 citations

Somatic cells efficiently join unrelated DNA segments end-to-end.

1982 • 91 citations

Ataxia-telangiectasia: a human mutation giving high-frequency misrepair of DNA double-stranded scissions.

1986 • 83 citations

Repair of double-strand breaks in a temperature conditional radiation-sensitive mutant of Saccharomyces cerevisiae

1982 • 66 citations

Gene recombination in X-ray-sensitive hamster cells.

1987 • 58 citations

Introduction and recovery of a selectable bacterial gene from the genome of mammalian cells.

1982 • 58 citations

Six complementation groups for ionising-radiation sensitivity in Chinese hamster cells

1988 • 55 citations

Recombination and ligation of transfected DNA in CHO mutant EM9, which has high levels of sister chromatid exchange.

1987 • 51 citations

Effect of DNA damage on the expression of the chloramphenicol acetyltransferase gene after transfection into diploid human fibroblasts

1985 • 51 citations

Molecular Studies on the Nature of the Repair Defect in Ataxia-Telangiectasia and Their Implications for Cellular Radiobiology

1987 • 48 citations

Nucleotide sequence of theEsherichia colixanthine-guanine phosphoribosyl transferase gene

1983 • 46 citations

Examination of vectors with two dominant, selectable genes for DNA repair and mutation studies in mammalian cells

1988 • 44 citations

The use of recombinant DNA plasmids for the determination of DNA-repair and recombination in cultured mammalian cells.

1984 • 43 citations

The use of a cloned bacterial gene to study mutation in mammalian cells

1983 • 41 citations

Genotoxicity of γ-irradiation in L5178Y mouse lymphoma cells

1986 • 39 citations

Homologous recombination in a Chinese hamster X-ray-sensitive mutant

1986 • 36 citations

The isolation and characterization of an X-ray-sensitive ultraviolet-resistant mutant of Escherichia coli

1971 • 27 citations

Enhancement of genetic transformation frequencies of mammalian cell cultures by damage to the cell DNA

1985 • 17 citations