The Nuclear Factor κ-B Signaling Pathway Participates in Dysregulation of Vascular Smooth Muscle Cells in Vitroand in Human Atherosclerosis

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion.

1996 • 795 citations

IκB-β regulates the persistent response in a biphasic activation of NF-κB

1995 • 780 citations

An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium.

1993 • 680 citations

Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA

1990 • 445 citations

NF-kappa B and I kappa B alpha: an inducible regulatory system in endothelial activation.

1994 • 416 citations

Constitutive NF-kB Activity in Neurons

1994 • 400 citations

Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6.

1990 • 364 citations

Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.

1994 • 362 citations

The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression

1995 • 354 citations

Functional angiotensin II receptors in cultured vascular smooth muscle cells.

1982 • 346 citations

Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.

1993 • 338 citations

Smooth muscle cells and the pathogenesis of the lesions of atherosclerosis

1993 • 332 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus.

1993 • 330 citations

In vivo control of NF-kappa B activation by I kappa B alpha.

1993 • 326 citations

Sustained activation of vascular cells and leukocytes in the rabbit aorta after balloon injury.

1993 • 268 citations

Culture of quiescent arterial smooth muscle cells in a defined serum‐free medium

1983 • 220 citations

Expression of a constitutive NF-kappa B-like activity is essential for proliferation of cultured bovine vascular smooth muscle cells.

1995 • 184 citations

Nitric Oxide Attenuates Vascular Smooth Muscle Cell Activation by Interferon-γ

1996 • 145 citations

Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity.

1994 • 114 citations

A Sustained Reduction in IκB-β May Contribute to Persistent NF-κB Activation in Human Endothelial Cells

1996 • 110 citations

Cytokines and smooth muscle cells in atherosclerosis

1993 • 109 citations

Two distinct mechanisms contribute to the constitutive activation of RelB in lymphoid cells.

1994 • 91 citations

Involvement of NF-κB Activation in Thrombin-Induced Human Vascular Smooth Muscle Cell Proliferation

1994 • 77 citations

Vascular smooth muscle cells express a constitutive NF-kappa B-like activity.

1994 • 76 citations

Synergistic interaction of interleukin‐1β and growth factors in primary cultures of rat aortic smooth muscle cells

1995 • 30 citations