Immune modulation in corneal transplantation

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

1989 • 2,771 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 • 2,574 citations

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

2003 • 2,177 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

The B7–CD28 superfamily

2002 • 1,646 citations

Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism

1999 • 1,560 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1999 • 1,418 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

CTLA-4–Ig regulates tryptophan catabolism in vivo

2002 • 1,150 citations

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

1995 • 1,048 citations

The Role of Interleukin-1 in Disease

1993 • 967 citations

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

1997 • 936 citations

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

1991 • 861 citations

T-cell regulation by CD28 and CTLA-4

2001 • 857 citations

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

1999 • 824 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

T-cell co-stimulation through B7RP-1 and ICOS

1999 • 758 citations

Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI.

1991 • 752 citations

Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation

2000 • 733 citations

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal.

1993 • 622 citations

CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells.

1991 • 562 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.

1990 • 487 citations

Cutting Edge: Induced Indoleamine 2,3 Dioxygenase Expression in Dendritic Cell Subsets Suppresses T Cell Clonal Expansion

2003 • 460 citations

Ligation of B7-1/B7-2 by Human CD4+ T Cells Triggers Indoleamine 2,3-Dioxygenase Activity in Dendritic Cells

2004 • 459 citations

Risk Factors for Corneal Graft Failure and Rejection in the Collaborative Corneal Transplantation Studies

1994 • 449 citations

Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist

1995 • 441 citations

Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154

1999 • 418 citations

Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection

1996 • 416 citations

CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival.

1997 • 375 citations

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

1998 • 359 citations

Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail) Is an Inhibitor of Autoimmune Inflammation and Cell Cycle Progression

2000 • 357 citations

Cells Expressing Indoleamine 2,3-Dioxygenase Inhibit T Cell Responses

2002 • 344 citations

Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation

2003 • 334 citations

Factors Predictive of Corneal Graft Survival

1992 • 323 citations

Importance of ICOS–B7RP-1 costimulation in acute and chronic allograft rejection

2001 • 317 citations

The role of B7 co‐stimulation in activation and differentiation ofCD4⁺and CD8⁺T cells

1998 • 306 citations

The Collaborative Corneal Transplantation Studies (CCTS)

1992 • 304 citations

HEART ALLOGRAFTS IN MURINE SYSTEMS

1992 • 299 citations

The interleukin‐12 subunit p40 specifically inhibits effects of the interleukin‐12 heterodimer

1993 • 292 citations

Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase

2004 • 290 citations

Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation.

1997 • 268 citations

Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production.

1993 • 251 citations

Langerhans Cells of the Ocular Surface

1982 • 239 citations

Characterization of Human Inducible Costimulator Ligand Expression and Function

2000 • 237 citations

Corneal allografts fail to express Ia antigens

1979 • 227 citations

T‐cell costimulatory pathways in allograft rejection and tolerance

2003 • 218 citations

The Impact of Corneal Allograft Rejection on the Long-Term Outcome of Corneal Transplantation

2005 • 211 citations

Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.

1999 • 209 citations

Indoleamine 2,3-Dioxygenase Expression in Transplanted NOD Islets Prolongs Graft Survival After Adoptive Transfer of Diabetogenic Splenocytes

2002 • 203 citations

B7-H1-Induced Apoptosis as a Mechanism of Immune Privilege of Corneal Allografts

2006 • 202 citations

New spectrum of allorecognition pathways: implications for graft rejection and transplantation tolerance

2004 • 195 citations

How successful is corneal transplantation? A report from the Australian corneal graft register

1995 • 180 citations

The CD40 pathway in allograft rejection, acceptance, and tolerance

1997 • 180 citations

Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-gamma in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy.

1995 • 175 citations

Conclusions of the corneal transplant follow up study

1997 • 174 citations

Function of indoleamine 2,3‐dioxygenase in corneal allograft rejection and prolongation of allograft survival by over‐expression

2006 • 164 citations

Impaired cell-mediated immunity in mice bearing healthy orthotopic corneal allografts.

1993 • 155 citations

Costimulation through CD28 enhances T cell-dependent B cell activation via CD40-CD40L interaction.

1994 • 154 citations

Promotion of murine orthotopic corneal allograft survival by systemic administration of anti-CD4 monoclonal antibody.

1991 • 151 citations

ROLE OF FAS-FAS LIGAND INTERACTIONS IN THE IMMUNOREJECTION OF ALLOGENEIC MOUSE CORNEAL TRANSPLANTS1

1997 • 147 citations

INCREASED EXPRESSION OF IL-4 AND IL-10 AND DECREASED EXPRESSION OF IL-2 AND INTERFERON-γ IN LONG-SURVIVING MOUSE HEART ALLOGRAFTS AFTER BRIEF CD4-MONOCLONAL ANTIBODY THERAPY1,2

1995 • 142 citations

Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease

1994 • 141 citations

PROLONGATION OF SHEEP CORNEAL ALLOGRAFT SURVIVAL BY EX VIVO TRANSFER OF THE GENE ENCODING INTERLEUKIN-101

2001 • 136 citations

TOPICAL INTERLEUKIN 1 RECEPTOR ANTAGONIST PROMOTES CORNEAL TRANSPLANT SURVIVAL1

1997 • 132 citations

Corneal Transplantation: The Forgotten Graft

2004 • 131 citations

Inflammatory Cytokines Induce Apoptosis of Corneal Endothelium through Nitric Oxide

2004 • 129 citations

The Expression of HLA Antigens by Cells in the Human Cornea

1984 • 124 citations

Enzymic formation of d-kynurenine from d-tryptophan

1967 • 120 citations

Identification and characterization of cells infiltrating the graft and aqueous humour in rat corneal allograft rejection

1997 • 118 citations

Role of CD4+ and CD8+ T Cells in Allorecognition: Lessons from Corneal Transplantation

2001 • 115 citations

Role of CD4+ T cells in immunobiology of orthotopic corneal transplants in mice.

1999 • 114 citations

Phagocytosis of particulate antigens by corneal epithelial cells stimulates interleukin-1 secretion and migration of Langerhans cells into the central cornea.

1989 • 113 citations

Immunosuppressive drugs in immune and inflammatory ocular disease

1991 • 109 citations

ADENOVIRUS-MEDIATED GENE DELIVERY TO THE CORNEAL ENDOTHELIUM1

1996 • 107 citations

The immune privilege of corneal grafts

2003 • 102 citations

Improvements in Gene Therapy

2002 • 98 citations

THE role of indoleamine 2,3‐dioxygenase in the anti‐tumour activity of human interferon‐γ in vivo

1995 • 93 citations

In Vivo Angiogenic Activity of Interleukins

1990 • 93 citations

Prolongation of rat corneal graft survival by treatment with anti-CD4 monoclonal antibody.

1992 • 90 citations

Immunological non-responsiveness and acquisition of tolerance in relation to immune privilege in the eye

1995 • 84 citations

Effect of administration of CTLA4-Ig as protein or cDNA on corneal allograft survival.

2002 • 83 citations

Clinical and Immunohistologic Studies of Corneal Rejection in the Rat Penetrating Keratoplasty Model

1991 • 82 citations

CYTOKINE AND CHEMOKINE EXPRESSION KINETICS AFTER CORNEAL TRANSPLANTATION1

2000 • 82 citations

Corticosteroid Therapy of Eye Disease

1996 • 80 citations

Corticosteroids in Corneal Graft Rejection

1991 • 78 citations

The distribution and ontogeny of MHC antigens in murine ocular tissue.

1987 • 77 citations

IMMUNOLOGY AND IMMUNOMODULATION OF CORNEAL TRANSPLANTATION

2002 • 77 citations

Interleukin-1 receptor antagonist suppresses Langerhans cell activity and promotes ocular immune privilege.

1998 • 76 citations

Report from the Australian Corneal Graft Registry.

1989 • 74 citations

Interleukin 1 Receptor Antagonist Suppresses Allosensitization in Corneal Transplantation

1998 • 70 citations

Prevention of corneal allograft rejection in rats treated with subconjunctival injections of liposomes containing dichloromethylene diphosphonate.

1994 • 68 citations

TREATMENT WITH INTERLEUKIN-4 PROLONGS ALLOGENEIC NEONATAL HEART GRAFT SURVIVAL BY INDUCING T HELPER 2 RESPONSES

1998 • 68 citations

Cytokine mRNA Expression During Experimental Corneal Allograft Rejection

1996 • 67 citations

Murine orthotopic corneal transplantation in high-risk eyes. Rejection is dictated primarily by weak rather than strong alloantigens.

1997 • 63 citations

Cytokine expression during orthotopic corneal allograft rejection in mice.

1998 • 63 citations

Effect of topically applied anti-CD4 monoclonal antibodies on orthotopic corneal allografts in a rat model.

1995 • 56 citations

TNF receptor secretion after ex vivo adenoviral gene transfer to cornea and effect on in vivo graft survival.

2001 • 55 citations

Randomised controlled trial of corticosteroid regimens in endothelial corneal allograft rejection

1999 • 54 citations

Effect of macrophage depletion on immune effector mechanisms during corneal allograft rejection in rats.

2000 • 53 citations

Early Expression of Proinflammatory Cytokines Interleukin-1 and Tumor Necrosis Factor-alpha after Corneal Transplantation

1999 • 52 citations

Differential Effects of Costimulatory Pathway Modulation on Corneal Allograft Survival

2006 • 51 citations

Prolongation of Sheep Corneal Allograft Survival by Transfer of the Gene Encoding Ovine IL-12-p40 but Not IL-4 to Donor Corneal Endothelium

2005 • 51 citations

Effect of cytokine-induced migration of Langerhans cells on corneal allograft survival

1995 • 50 citations

Prevention of immune-mediated corneal graft destruction with the anti-lymphocyte monoclonal antibody, CAMPATH-1H

1995 • 50 citations

Influence of local and systemic CTLA4Ig gene transfer on corneal allograft survival

2006 • 50 citations

DETECTION OF MINOR ALLOANTIGEN-SPECIFIC CYTOTOXIC T CELLS AFTER REJECTION OF MURINE ORTHOTOPIC CORNEAL ALLOGRAFTS

1999 • 49 citations

Ballistic transfer of minimalistic immunologically defined expression constructs for IL4 and CTLA4 into the corneal epithelium in mice after orthotopic corneal allograft transplantation

2000 • 47 citations

Local Overexpression of Nerve Growth Factor in Rat Corneal Transplants Improves Allograft Survival

2007 • 45 citations

SHORT COMMUNICATION: Induction of donor-specific ACAID can prolong orthotopic corneal allograft survival in "high-risk" eyes

1997 • 45 citations

Effects of local and systemic viral interleukin-10 gene transfer on corneal allograft survival

2006 • 45 citations

Blockade of CD40-CD154 costimulatory pathway promotes survival of allogeneic corneal transplants.

2001 • 44 citations

Local bioactive tumour necrosis factor (TNF) in corneal allotransplantation

2000 • 42 citations

Survival of corneal allografts following adenovirus-mediated gene transfer of interleukin-4

2000 • 42 citations

Report of the Organ Transplant Panel

1988 • 41 citations

MURINE INTERLEUKIN 4 TRANSGENIC HEART ALLOGRAFT SURVIVAL PROLONGED WITH DOWN-REGULATION OF THE TH1 CYTOKINE mRNA IN GRAFTS

1997 • 40 citations

Modulation of Costimulation by CD28 and CD154 Alters the Kinetics and Cellular Characteristics of Corneal Allograft Rejection

2003 • 39 citations

Immunosuppression in pediatric solid organ transplantation: Opportunities, risks, and management

2006 • 35 citations

PATTERNS OF CORNEAL GRAFT REJECTION IN THE RABBIT AND REVERSAL OF REJECTION WITH MONOCLONAL ANTIBODIES

1992 • 32 citations

Tolerogenic response: Allorecognition pathways

2006 • 32 citations

Protection of Corneal Allografts by CTLA4-Ig

1999 • 29 citations

??/??-T CELL RECEPTOR-DIRECTED THERAPY IN RAT ALLOGRAFT RECIPIENTS

1996 • 28 citations

Inhibition of corneal allograft reaction by CTLA4-Ig

1997 • 27 citations

INDUCTION OF SPECIFIC UNRESPONSIVENESS TO CARDIAC ALLOGRAFTS BY SHORT-TERM ADMINISTRATION OF ANTI T CELL RECEPTOR αβ ANTIBODY1

1994 • 26 citations

Usefulness of CD3 or CD6 anti-T monoclonal antibodies in the treatment of acute corneal graft rejection.

1989 • 26 citations

Interleukin-1 receptor antagonist therapy and induction of anterior chamber-associated immune deviation-type tolerance after corneal transplantation.

2000 • 26 citations

Acute rejection of orthotopic corneal xenografts in mice depends on CD4(+) T cells and self-antigen-presenting cells.

2001 • 25 citations

Effect of Locally Administered Anti-CD154 (CD40 Ligand) Monoclonal Antibody on Survival of Allogeneic Corneal Transplants

2002 • 24 citations

EFFECT OF INTERLEUKIN-10 ON HUMAN ANTI-PORCINE XENOGENEIC CELLULAR RESPONSE IN VITRO

2000 • 22 citations

SUPPRESSION OF ALLOGRAFT REJECTION WITH ANTI-???? T CELL RECEPTOR ANTIBODY IN RAT CORNEAL TRANSPLANTATION1

1999 • 22 citations

The hyper IgM syndrome

2001 • 22 citations

Direct and Indirect Allorecognition

2006 • 20 citations

Roles of tumor necrosis factor-related apoptosis-inducing ligand in corneal transplantation

2003 • 19 citations

Local or short‐term systemic costimulatory molecule blockade prolongs rat corneal allograft survival

2005 • 19 citations

CD8⁺T Cell-Mediated Delayed Rejection of Orthotopic Guinea Pig Cornea Grafts in Mice Deficient in CD4⁺T Cells

2003 • 19 citations

Corneal rat-to-mouse xenotransplantation and the effects of anti-CD4 or anti-CD8 treatment on cytokine and nitric oxide production

2005 • 18 citations

Interleukin 10 Treatment Does Not Prolong Experimental Corneal Allograft Survival

1999 • 17 citations

Immunomodulation with anti-αβ T-cell receptor monoclonal antibodies in combination with cyclosporine a improves regeneration in nerve allografts

2006 • 16 citations

Mechanisms of Immunotherapeutic Intervention by Anti-CD154 (CD40L) Antibody in High-Risk Corneal Transplantation

2002 • 15 citations

Report of the organ transplant panel. Corneal transplantation. Council on Scientific Affairs

1988 • 10 citations

INDUCTION OF LONG-TERM RAT RENAL ALLOGRAFT SURVIVAL BY PRETRANSPLANT T CELL RECEPTOR-??/??-TARGETED THERAPY1

1996 • 8 citations

[CTLA4-Ig prevents corneal allograft rejection in mice].

2004 • 5 citations

Effects of CTLA4-Ig gene-modified dendritic cells on the corneal allografts

2006 • 3 citations

[Effect of IL-1 receptor antagonist on cell apoptosis in rat corneal grafts].

2006 • 1 citations

[Effects of IL-1 receptor antagonist on the level of cytokine in the rat corneal grafts and aqueous humor after corneal transplantation].

2003 • 1 citations