Role of CD4+ and CD8+ T Cells in Allorecognition: Lessons from Corneal Transplantation

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

2000 • 879 citations

Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells.

1982 • 807 citations

The Technique of Free Skin Grafting in Mammals

1951 • 760 citations

Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection.

1990 • 561 citations

The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice.

1993 • 325 citations

CD4+ but not CD8+ cells are essential for allorejection.

1996 • 303 citations

Contributions of Direct and Indirect T Cell Alloreactivity During Allograft Rejection in Mice

1999 • 303 citations

ORTHOTOPIC CORNEAL TRANSPLANTATION IN MICE—EVIDENCE THAT THE IMMUNOGENETIC RULES OF REJECTION DO NOT APPLY

1992 • 298 citations

Cellular Basis of Skin Allograft Rejection: An In Vivo Model of Immune-Mediated Tissue Destruction

1992 • 295 citations

Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection.

1992 • 266 citations

Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences.

1986 • 229 citations

Corneal allografts fail to express Ia antigens

1979 • 227 citations

Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo.

1994 • 227 citations

Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides.

1992 • 218 citations

Delayed type hypersensitivity: Current theories with a historic perspective

1999 • 208 citations

Split Anergy in a CD8 ⁺ T Cell: Receptor-dependent Cytolysis in the Absence of Interleukin-2 Production

1991 • 199 citations

Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection.

1987 • 198 citations

THE IMMUNE PRIVILEGE OF CORNEAL ALLOGRAFTS1

1999 • 175 citations

Single-Cytokine-Producing CD4 Memory Cells Predominate in Type 1 and Type 2 Immunity

2000 • 174 citations

The distribution of HLA antigens on human corneal tissue.

1984 • 157 citations

Impaired cell-mediated immunity in mice bearing healthy orthotopic corneal allografts.

1993 • 155 citations

Promotion of murine orthotopic corneal allograft survival by systemic administration of anti-CD4 monoclonal antibody.

1991 • 151 citations

Variations in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses.

1995 • 148 citations

Identification and characterization of cells infiltrating the graft and aqueous humour in rat corneal allograft rejection

1997 • 118 citations

Defects of T-cell effector function and post-thymic maturation in X-linked hyper-IgM syndrome

1999 • 115 citations

Role of CD4+ T cells in immunobiology of orthotopic corneal transplants in mice.

1999 • 114 citations

The cellular basis of allograft rejection in vivo. I. The cellular requirements for first-set rejection of heart grafts.

1978 • 113 citations

T cell recognition of allo-peptides in context of syngeneic MHC

1991 • 98 citations

T cells reactive to a single immunodominant self-restricted allopeptide induce skin graft rejection in mice.

1998 • 96 citations

Cells Mediating Allograft Rejection

1984 • 94 citations

T-cell mediated responses in a murine model of orthotopic corneal transplantation.

1995 • 91 citations

The Role of Graft-derived Dendritic Leukocytes in the Rejection of Vascularized Organ Allografts

1990 • 87 citations

Characterization of cell-mediated immune responses elicited by orthotopic corneal allografts in mice.

1995 • 85 citations

Limited T cell response to donor MHC peptides during allograft rejection. Implications for selective immune therapy in transplantation.

1994 • 85 citations

T cell recognition of allopeptides in context of syngeneic MHC.

1992 • 78 citations

Minor H, rather than MHC, alloantigens offer the greater barrier to successful orthotopic corneal transplantation in mice

1996 • 74 citations

Adoptively transferred CD4+ lymphocytes from CD8 -/- mice are sufficient to mediate the rejection of MHC class II or class I disparate skin grafts.

1996 • 72 citations

Type 2 Immune Deviation Has Differential Effects on Alloreactive CD4+ and CD8+ T Cells

1998 • 71 citations

CD8+ EFFECTOR CELLS RESPONDING TO RESIDUAL CLASS I ANTIGENS, WITH HELP FROM CD4+ CELLS STIMULATED INDIRECTLY, CAUSE REJECTION OF ???MAJOR HISTOCOMPATIBILITY COMPLEX-DEFICIENT??? SKIN GRAFTS1

1997 • 59 citations

ROLE OF INDIRECT ALLORECOGNITION IN EXPERIMENTAL LATE ACUTE REJECTION1,2

1997 • 58 citations

Intramolecular and intermolecular spreading during the course of organ allograft rejection

1998 • 55 citations

CD4+ T CELLS ARE CRITICAL FOR CORNEAL, BUT NOT SKIN, ALLOGRAFT REJECTION1

2000 • 53 citations

Critical Role of Costimulation in the Activation of Naive Antigen-Specific TCR Transgenic CD8+ T Cells In Vitro

1999 • 52 citations

Role of donor-specific cytotoxic T cells in rejection of corneal allografts in normal and high-risk eyes

1996 • 51 citations

Purified MHC Class I and Peptide Complexes Activate Naive CD8+ T Cells Independently of the CD28/B7 and LFA-1/ICAM-1 Costimulatory Interactions

1998 • 50 citations

Role of co-stimulation in CD8+ T cell activation

1998 • 50 citations

Evidence for involvement of dual-function T cells in rejection of MHC class I disparate skin grafts. Assessment of MHC class I alloantigens as in vivo helper determinants.

1988 • 47 citations

Identifying and Misidentifying the Brown Recluse Spider

1999 • 42 citations

MEDIATION OF SKIN ALLOGRAFT REJECTION IN scid MICE BY CD4+ AND CD8+ T CELLS

1992 • 42 citations

IMMUNE MECHANISMS IN ORGAN ALLOGRAFT REJECTION

1983 • 38 citations

Corneal allografts induce cytotoxic T cell but not delayed hypersensitivity responses in mice.

1985 • 27 citations

Effector cells must recognize antigens expressed in the graft to cause efficient skin graft rejection in SCID mice.

1995 • 26 citations

CD4+ T CELLS RESPONSIVE THROUGH THE INDIRECT PATHWAY CAN MEDIATE SKIN GRAFT REJECTION IN THE ABSENCE OF INTERFERON-??1

2000 • 25 citations

IMMUNE MECHANISMS IN ORGAN ALLOGRAFT REJECTION

1985 • 24 citations

Segregation of type 1 cytokine production in human peripheral blood lymphocytes: phenotypic differences between IFN-γ and IL-2-producing cells in the CD8+ T cell subset

1998 • 20 citations

Indirect allorecognition is involved in both acute and chronic allograft rejection

1999 • 16 citations