MURINE INTERLEUKIN 4 TRANSGENIC HEART ALLOGRAFT SURVIVAL PROLONGED WITH DOWN-REGULATION OF THE TH1 CYTOKINE mRNA IN GRAFTS

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

PRIMARILY VASCULARIZED ALLOGRAFTS OF HEARTS IN MICE

1973 • 801 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

1991 • 479 citations

IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice

1990 • 410 citations

Cytokine patterns in the pathogenesis of human leishmaniasis.

1993 • 372 citations

Isolation and characterization of the mouse cardiac myosin heavy chain genes

1991 • 331 citations

HEART ALLOGRAFTS IN MURINE SYSTEMS

1992 • 299 citations

IL-2 knockout recipient mice reject islet cell allografts.

1995 • 204 citations

Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-gamma in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy.

1995 • 175 citations

Osteoporosis induced in mice by overproduction of interleukin 4.

1993 • 159 citations

ENHANCED TYPE 2 AND DIMINISHED TYPE 1 CYTOKINES IN NEONATAL TOLERANCE

1995 • 148 citations

Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction. Regulation of cytokines and CD8+ lymphoid engraftment.

1994 • 147 citations

INCREASED EXPRESSION OF IL-4 AND IL-10 AND DECREASED EXPRESSION OF IL-2 AND INTERFERON-γ IN LONG-SURVIVING MOUSE HEART ALLOGRAFTS AFTER BRIEF CD4-MONOCLONAL ANTIBODY THERAPY1,2

1995 • 142 citations

Evidence for functional heterogeneity of rat CD4+ T cells in vivo. Differential expression of IL-2 and IL-4 mRNA in recipients of cardiac allografts.

1992 • 88 citations

COMBINED THERAPY WITH INTERLEUKIN-4 AND INTERLEUKIN-10 INHIBITS AUTOIMMUNE DIABETES RECURRENCE IN SYNGENEIC ISLET-TRANSPLANTED NONOBESE DIABETIC MICE ANALYSIS OF CYTOKINE MRNA EXPRESSION IN THE GRAFT

1995 • 75 citations

Cytokines and Peripheral Tolerance to Alloantigen

1993 • 69 citations

Rapamycin inhibits production of cytotoxic but not noncytotoxic antibodies and preferentially activates T helper 2 cells that mediate long-term survival of heart allografts in rats.

1994 • 61 citations

Spontaneous acceptance of rat liver allografts is associated with an early downregulation of intragraft interleukin-4 messenger RNA expression

1995 • 46 citations

Major histocompatibility complex class II hyperexpression on B cells in interleukin 4‐transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia

1991 • 42 citations

PREVENTION OF ORTHOTOPIC LIVER ALLOGRAFT REJECTION IN RATS WITH A SHORT-TERM BREQUINAR SODIUM THERAPY

1994 • 41 citations

Detection of α1-adrenoceptor subtypes in human hypertrophied prostate byin situ hybridizationsubtypes in human hypertrophied prostate byin situ hybridization

1996 • 39 citations

ADMINISTRATION OF INTRAGRAFT INTERLEUKIN-4 PROLONGS CARDIAC ALLOGRAFT SURVIVAL IN RATS TREATED WITH DONOR-SPECIFIC TRANSFUSION/CYCLOSPORINE

1995 • 38 citations

Adoptive transfer of a T_h2-like cell line prolongs MHC class II antigen disparate skin allograft survival in the mouse

1994 • 36 citations

ALLOANTIGEN PRIMING AFTER TOTAL LYMPHOID IRRADIATION ALTERS ALLOIMMUNE CYTOKINE RESPONSES

1995 • 26 citations

DETECTION OF CYTOKINE mRNA IN VIVO BY POLYMERASE CHAIN REACTION

1993 • 25 citations

Blocking cell microtubule assembly inhibits the alloimmune response in vitro and prolongs renal allograft survival by inhibition of Th1 and sparing of Th2 cell function in vivo.

1995 • 16 citations

Alterations of the interleukin-4 pathway in production of tolerance by mixed hematopoietic chimerism*

1995 • 9 citations