Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease

CLINICAL MANIFESTATIONS OF GRAFT-VERSUS-HOST DISEASE IN HUMAN RECIPIENTS OF MARROW FROM HL-A-MATCHED SIBLING DONOR,S

1974 • 3,686 citations

Quantitation of mRNA by the polymerase chain reaction.

1989 • 1,648 citations

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1990 • 1,143 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

The Role of Interleukin-1 in Disease

1993 • 967 citations

THE ROLE OF ENDOTHELIAL CELLS IN INFLAMMATION

1990 • 808 citations

OPTIMIZATION OF PCRs

1990 • 632 citations

Cytokine dysregulation and acute graft-versus-host disease

1992 • 617 citations

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease.

1987 • 609 citations

Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantation [see comments]

1990 • 591 citations

A retrospective analysis of therapy for acute graft-versus-host disease: secondary treatment

1991 • 577 citations

Cytokine dysregulation and acute graft-versus-host disease

1992 • 565 citations

Induction of Graft-versus-Host Disease as Immunotherapy for Relapsed Chronic Myeloid Leukemia

1994 • 510 citations

Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open-label, placebocontrolled multicenter trial

1994 • 488 citations

A specific receptor antagonist for interleukin 1 prevents Escherichia coli ‐induced shock in rabbits

1991 • 435 citations

Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: long-term follow-up of a controlled trial

1989 • 434 citations

Treatment of moderate/severe acute graft-versus-host disease after allogeneic bone marrow transplantation: an analysis of clinical risk features and outcome

1990 • 353 citations

Differential cytokine expression in acute and chronic murine graft‐versus‐host‐disease

1993 • 194 citations

Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease

1991 • 180 citations

Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host disease

1992 • 176 citations

Treatment of corticosteroid resistant acute graft-versus-host disease by in vivo administration of anti-interleukin-2 receptor monoclonal antibody (B-B10) [see comments]

1990 • 148 citations

INTERLEUKIN-1 IS A CRITICAL EFFECTOR MOLECULE DURING CYTOKINE DYSREGULATION IN GRAFT VERSUS HOST DISEASE TO MINOR HISTOCOMPATIBILITY ANTIGENS1

1993 • 134 citations

Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies

1991 • 133 citations

THE RELATIONSHIP OF SERUM IL-6 LEVELS TO ACUTE GRAFT-VERSUS-HOST DISEASE AND HEPATORENAL DISEASE AFTER HUMAN BONE MARROW TRANSPLANTATION

1992 • 92 citations

Acute graft-versus-host disease following unrelated donor marrow transplantation: failure of conventional therapy.

1992 • 85 citations

Graft-Versus-Host Disease

1990 • 77 citations

Interleukin-1 (IL-1) receptor antagonist prevents Staphylococcus epidermidis-induced hypotension and reduces circulating levels of tumor necrosis factor and IL-1 beta in rabbits

1993 • 74 citations

SERUM TUMOR NECROSIS FACTOR ALPHA ASSOCIATED WITH ACUTE GRAFT-VERSUS-HOST DISEASE IN HUMANS

1990 • 64 citations

In vivo administration of granulocyte colony-stimulating factor (G- CSF), granulocyte-macrophage CSF, interleukin-1 (IL-1), and IL-4, alone and in combination, after allogeneic murine hematopoietic stem cell transplantation

1991 • 61 citations

A PHASE I-II STUDY EVALUATING THE MURINE ANTI-IL-2 RECEPTOR ANTIBODY 2A3 FOR TREATMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE

1990 • 56 citations

CELLULAR INTERACTIONS IN MARROW-GRAFTED PATIENTS

1985 • 50 citations

A study of cytokine production in acute graft-vs-host disease

1991 • 36 citations

Anti-interleukin-2 receptor monoclonal antibody (BT 563) in the treatment of severe acute GVHD refractory to systemic corticosteroid therapy.

1992 • 35 citations

Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: long-term follow-up of a controlled trial

1989 • 32 citations

A retrospective analysis of therapy for acute graft-versus-host disease: secondary treatment

1991 • 14 citations

Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies

1991 • 12 citations