The interleukin‐12 subunit p40 specifically inhibits effects of the interleukin‐12 heterodimer

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

1991 • 861 citations

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

1990 • 679 citations

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

1991 • 593 citations

Role of Lymphocyte Adhesion Receptors in Transient Interactions and Cell Locomotion

1991 • 532 citations

Cloning and expression of murine IL-12.

1992 • 474 citations

Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor).

1991 • 471 citations

Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

1991 • 457 citations

The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs.

1983 • 386 citations

IL-12 receptor. II. Distribution and regulation of receptor expression.

1992 • 298 citations

Lymphokine and nonlymphokine mRNA levels in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A.

1986 • 293 citations

Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2.

1992 • 284 citations

Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1.

1983 • 255 citations

Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism.

1991 • 243 citations

Interleukin‐12/T cell stimulating factor, a cytokine with multiple effects on T helper type 1 (T_h1) but not on T_h2 cells

1993 • 241 citations

Granulocyte-macrophage colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation function.

1988 • 227 citations

Cloned T Lymphocytes and Monoclonal Antibodies as Probes for Cell Surface Molecules Active in T Cell‐Mediated Cytolysis

1982 • 219 citations

Recombinant interleukin-12 suppresses the synthesis of immunoglobulin E by interleukin-4 stimulated human lymphocytes.

1992 • 209 citations

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients.

1992 • 198 citations

A microplaque reduction assay for human and mouse interferon

1975 • 158 citations

Interleukin 2 induces gamma-interferon production: participation of macrophages and NK-like cells.

1983 • 155 citations

IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts.

1991 • 111 citations

A single monoclonal anti-Ia antibody inhibits antigen-specific T cell proliferation controlled by distinct Ir genes mapping in different H-2 I subregions.

1982 • 31 citations

Different accessory function for T_H1 cells of bone marrow derived macrophages cultured in granulocyte macrophage colony stimulating factor or macrophage colony stimulating factor

1992 • 18 citations

Requirements for the growth of T_H1 lymphocyte clones

1990 • 17 citations

Processing Requirements for the Recognition of Insulin Fragments by Murine T cells

1988 • 16 citations

An alternative pathway of induction of lymphokine production by T lymphocyte clones.

1989 • 16 citations

Induction of IL-2 receptor expression and proliferation of T cell clones by a novel cytokine(s)

1992 • 12 citations

Components of an antigen‐/T cell receptor‐independent pathway of lymphokine production

1991 • 8 citations