Regulation of Tumor Growth by IFN-Γ in Cancer Immunotherapy

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice

1998 • 1,400 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling

1997 • 1,001 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

1995 • 686 citations

The role of CD4+ T cell responses in antitumor immunity

1998 • 678 citations

Adoptive T Cell Therapy of Tumors: Mechanisms Operative in the Recognition and Elimination of Tumor Cells

1991 • 619 citations

Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFNγ receptors

1994 • 619 citations

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

1994 • 527 citations

CD4 + T Cell–Mediated Tumor Rejection Involves Inhibition of Angiogenesis that Is Dependent on IFNγ Receptor Expression by Nonhematopoietic Cells

2000 • 505 citations

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

1996 • 480 citations

Evidence for the involvement of endotheliai cell integrin αVβ3 in the disruption of the tumor vascuiature induced by TNF and IFN-γ

1998 • 461 citations

Distinct Role of Antigen-Specific T Helper Type 1 (Th1) and Th2 Cells in Tumor Eradication in Vivo

1999 • 445 citations

NK susceptibility varies inversely with target cell class I HLA antigen expression.

1987 • 433 citations

Processing of Some Antigens by the Standard Proteasome but Not by the Immunoproteasome Results in Poor Presentation by Dendritic Cells

2000 • 418 citations

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.

1990 • 409 citations

CD4⁺T cells eliminate MHC class II-negative cancer cellsin vivoby indirect effects of IFN-γ

1999 • 378 citations

Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases.

1996 • 358 citations

Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells.

1995 • 326 citations

Tumor Cell Responses to IFNγ Affect Tumorigenicity and Response to IL-12 Therapy and Antiangiogenesis

1998 • 324 citations

Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor.

1986 • 302 citations

Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells.

1985 • 295 citations

The CXC Chemokines IP-10 and Mig Are Necessary for IL-12-Mediated Regression of the Mouse RENCA Tumor

1998 • 295 citations

Tumor escape from immune recognition: lethal recurrent melanoma in a patient associated with downregulation of the peptide transporter protein TAP-1 and loss of expression of the immunodominant MART-1/Melan-A antigen.

1996 • 285 citations

Recombinant tumor necrosis factor: its effect and its synergism with interferon-γ on a variety of normal and transformed human cell lines

1986 • 279 citations

Interferon-γ Modulates a p53-independent Apoptotic Pathway and Apoptosis-related Gene Expression

1997 • 276 citations

Mig, the Monokine Induced By Interferon-γ, Promotes Tumor Necrosis In Vivo

1997 • 251 citations

THE ROLE OF CXC CHEMOKINES AS REGULATORS OF ANGIOGENESIS

1995 • 240 citations

Antiangiogenic gene therapy

1998 • 201 citations

Contribution of Natural Killer Cells to Inhibition of Angiogenesis by Interleukin-12

1999 • 192 citations

In Vivo Persistence of CD8 Polarized T Cell Subsets Producing Type 1 or Type 2 Cytokines

1998 • 179 citations

Interferon-gamma reduces macrophage-suppressive activity by inhibiting prostaglandin E2 release and inducing interleukin 1 production.

1984 • 166 citations

Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: Ia restriction and cognate vs. noncognate interactions in cytolysis

1984 • 152 citations

IL-12 regulates VEGF and MMPs in a murine breast cancer model

1998 • 138 citations

Functional Dissociation Between Local and Systemic Immune Response During Anti-Melanoma Peptide Vaccination

1998 • 127 citations

Strong expression of the lymphoattractant C-X-C chemokine Mig is associated with heavy infiltration of T cells in human malignant melanoma

1999 • 125 citations

Analysis of the major histocompatibility complex class I antigen presentation machinery in normal and malignant renal cells: evidence for deficiencies associated with transformation and progression.

1996 • 123 citations

Infiltration of tumors by systemically transferred tumor-reactive T lymphocytes is required for antitumor efficacy.

1999 • 115 citations

IFN-γ Can Promote Tumor Evasion of the Immune System In Vivo by Down-Regulating Cellular Levels of an Endogenous Tumor Antigen

2000 • 113 citations

Cutaneous T Cell Lymphoma Reactive CD4+ Cytotoxic T Lymphocyte Clones Display a Th1 Cytokine Profile and Use a Fas-Independent Pathway for Specific Tumor Cell Lysis

2000 • 104 citations

Modulation of murine tumor major histocompatibility antigens by cytokines in vivo and in vitro.

1988 • 101 citations

Type 1 and Type 2 CD8+ Effector T Cell Subpopulations Promote Long-Term Tumor Immunity and Protection to Progressively Growing Tumor

2000 • 84 citations

Functionally inactivating point mutation in the tumor-suppressorIRF-1 gene identified in human gastric cancer

1998 • 84 citations

Cytokine‐mediated modulation of HLA‐class II, ICAM‐1, LFA‐3 and tumor‐associated antigen profile of melanoma cells. comparison with anti‐proliferative activity by RIL1‐β, RTNF‐α, RIFN‐γ, RIl4 and their combinations

1990 • 81 citations

Interleukin-12 Inhibits Angiogenesis Induced by Human Tumor Cell Lines In Vivo

1996 • 67 citations

Multiple roles of interferon-gamma in the mediation of interleukin 12-induced tumor regression.

1998 • 65 citations

IFN-gamma-mediated coordinated transcriptional regulation of the human TAP-1 and LMP-2 genes in human renal cell carcinoma.

1997 • 62 citations

Transfection of beta 2-microglobulin restores IFN-mediated protection from natural killer cell lysis in YAC-1 lymphoma variants.

1990 • 60 citations

Modulation of carcinoembryonic antigen messenger RNA levels in human colon carcinoma cells by recombinant human gamma-interferon.

1989 • 51 citations

Inhibition of cellular responsiveness to interferon-gamma (IFN gamma) induced by overexpression of inactive forms of the IFN gamma receptor

1993 • 51 citations

Transcription factors IRF-1 and IRF-2: Linking the immune responses and tumor suppression

1997 • 46 citations

Cloned protein antigen-specific, Ia-restricted T cells with both helper and cytolytic activities: Mechanisms of activation and killing

1987 • 46 citations

Surface receptors delivering opposite signals regulate the function of human NK cells

2000 • 45 citations

Interferon-gamma and CXC chemokine induction by interleukin 12 in renal cell carcinoma.

1999 • 42 citations

Immunological functions of macrophages and their regulation by interferons.

1985 • 39 citations

Evidence for the elevation of serum carcinoembryonic antigen and tumor-associated glycoprotein-72 levels in patients administered interferons.

1991 • 33 citations

Rejection of an IA+ variant line of FBL-3 leukemia by cytotoxic T lymphocytes with CD4+ and CD4-CD8- T cell receptor-alpha beta phenotypes generated in CD8-depleted C57BL/6 mice.

1993 • 24 citations

The Tumor Recall Response of Antitumor Immunity Primed by a Live, Recombinant Listeria monocytogenes Vaccine Comprises Multiple Effector Mechanisms

2001 • 18 citations

Systemic Therapy of Advanced Metastatic Malignant Melanoma with a Combination of Fibroblast Interferon-β and Recombinant Interferon-γ

1990 • 15 citations

Down-regulation of transforming growth factor-beta and interleukin-10 secretion from malignant glioma cells by cytokines and anticancer drugs.

1998 • 14 citations

Lytic susceptibility of target cells to cytotoxic T cells is determined by their constitutive major histocompatibility complex class I antigen expression and cytokine-induced activation status.

1994 • 9 citations