The role of CD4+ T cell responses in antitumor immunity

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

1997 • 1,235 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen.

1996 • 992 citations

Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response

1990 • 926 citations

Vaccination with cytotoxic T lymphocyte epitope‐containing peptide protects against a tumor induced by human papillomavirus type 16‐transformed cells

1993 • 827 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

Simultaneous Humoral and Cellular Immune Response against Cancer–Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2–binding Peptide Epitopes

1998 • 728 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

B cells inhibit induction of T cell-dependent tumor immunity

1998 • 393 citations

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy

1997 • 316 citations

CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells

1998 • 300 citations

Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells.

1985 • 295 citations

Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene.

1994 • 287 citations

Melanoma-specific CD4+ T cells recognize nonmutated HLA-DR-restricted tyrosinase epitopes.

1996 • 259 citations

Principles for Adoptive T Cell Therapy of Human Viral Diseases

1995 • 256 citations

The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40.

1996 • 254 citations

Interleukin 7 induces CD4+ T cell-dependent tumor rejection.

1991 • 245 citations

A unique tumor antigen produced by a single amino acid substitution

1995 • 230 citations

Influence of interleukin 12 on p53 peptide vaccination against established Meth A sarcoma.

1995 • 218 citations

Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy

1997 • 205 citations

In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression.

1994 • 196 citations

Role of neutrophils and CD4+ T lymphocytes in the primary and memory response to nonimmunogenic murine mammary adenocarcinoma made immunogenic by IL-2 gene.

1992 • 185 citations

Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12VAL) peptide vaccination of a patient, recognize 12VAL-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation

1997 • 163 citations

Regression of established murine carcinoma metastases following vaccination with tumour-associated antigen peptides

1995 • 162 citations

Tumor immunotherapy: the tumor cell as an antigen-presenting cell

1994 • 132 citations

Differential T helper cell responses to human papillomavirus type 16 E7 related to viral clearance or persistence in patients with cervical neoplasia: a longitudinal study.

1998 • 118 citations

HLA-DR1–Restricted bcr-abl (b3a2)-Specific CD4+ T Lymphocytes Respond to Dendritic Cells Pulsed With b3a2 Peptide and Antigen-Presenting Cells Exposed to b3a2 Containing Cell Lysates

1997 • 105 citations

A case report: Immune responses and clinical course of the first human use of granulocyte/macrophage-colony-stimulating-factor-transduced autologous melanoma cells for immunotherapy

1997 • 101 citations

MHC class II restricted tumor antigens and the role of CD4+ T cells in cancer immunotherapy

1994 • 98 citations

Regression of established tumors in mice mediated by the oral administration of a recombinant Listeria monocytogenes vaccine.

1995 • 94 citations

Isolation of novel HLA-DR restricted potential tumor-associated antigens from the melanoma cell line FM3.

1997 • 81 citations

CD4+ T-cell immunity to mutated ras protein in pancreatic and colon cancer patients.

1995 • 63 citations

Interleukin 3 enhances development of tumor-reactive cytotoxic cells by a CD4-dependent mechanism.

1993 • 47 citations

T cells recognize the VH complementarity‐determining region 3 of the idiotypic protein of B cell non‐Hodgkin's lymphoma

1997 • 45 citations

Distinct proliferative T cell clonotypes are generated in response to a murine retrovirus-induced syngeneic T cell leukemia: viral gp70 antigen-specific MT4+ clones and Lyt-2+ cytolytic clones which recognize a tumor-specific cell surface antigen.

1985 • 44 citations

Adoptive chemoimmunotherapy of murine leukemia with helper T lymphocyte clones.

1987 • 39 citations

Characterisation of immune responses in pancreatic carcinoma patients after mutant p21 ras peptide vaccination

1996 • 30 citations

Interactions between Autologous CD4+and CD8+T Lymphocytes and Human Squamous Cell Carcinoma of the Head and Neck

1997 • 29 citations

Specificities and functions of CD4+ HLA class II-restricted T cell clones against a human sarcoma: evidence for several recognized antigens.

1996 • 20 citations

HLA-DR1–Restricted bcr-abl (b3a2)-Specific CD4+ T Lymphocytes Respond to Dendritic Cells Pulsed With b3a2 Peptide and Antigen-Presenting Cells Exposed to b3a2 Containing Cell Lysates

1997 • 20 citations

CD4+Hepatic Cancer-Specific Cytotoxic T Lymphocytes in Patients with Hepatocellular Carcinoma

1997 • 16 citations

Dominant TCRB-V-J chain usage and clonal expansion of sarcoma-reactive CD4+ HLA-DR-restricted T cells suggest a limited set of immunodominant sarcoma antigens

1997 • 10 citations

Cited By (0)

No citing papers found in database