Cutaneous T Cell Lymphoma Reactive CD4+ Cytotoxic T Lymphocyte Clones Display a Th1 Cytokine Profile and Use a Fas-Independent Pathway for Specific Tumor Cell Lysis

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

EORTC Classification for Primary Cutaneous Lymphomas: A Proposal From the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer

1997 • 1,298 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand.

1996 • 894 citations

Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

1987 • 497 citations

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.

1990 • 409 citations

Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.

1994 • 386 citations

The host—tumor immune conflict: from immunosuppression to resistance and destruction

1997 • 363 citations

Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back.

1997 • 342 citations

Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells.

1994 • 309 citations

Interleukin-10

1992 • 303 citations

Constitutive Activation of NF-κB Causes Resistance to Apoptosis in Human Cutaneous T Cell Lymphoma HuT-78 Cells

1998 • 300 citations

Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.

1994 • 294 citations

TGF-beta contributes to the shift toward Th2-type responses through direct and IL-10-mediated pathways in tumor-bearing mice.

1996 • 274 citations

Interleukin-12 Therapy of Cutaneous T-Cell Lymphoma Induces Lesion Regression and Cytotoxic T-Cell Responses

1999 • 272 citations

Th2 Cytokine mRNA Expression in Skin in Cutaneous T-Cell Lymphoma

1994 • 271 citations

Aberrant Cytokine Production By Sezary Syndrome Patients: Cytokine Secretion Pattern Resembles Murine Th2 Cells

1992 • 252 citations

Mechanism and Biological Significance of CD4‐mediated Cytotoxicity

1995 • 211 citations

Bystander Target Cell Lysis and Cytokine Production by Dengue Virus-Specific Human CD4⁺Cytotoxic T-Lymphocyte Clones

1999 • 190 citations

Mycosis Fungoides Exhibits a Th1-Type Cell-Mediated Cytokine Profile Whereas Sezary Syndrome Express a Th2-Type Profile

1994 • 179 citations

Sezary syndrome T-cell clones display T-helper 2 cytokines and express the accessory factor-1 (interferon-gamma receptor beta-chain)

1996 • 172 citations

Isolation of Tumor-Specific Cytotoxic CD4+ and CD4+CD8dim+ T-Cell Clones Infiltrating a Cutaneous T-Cell Lymphoma

1998 • 144 citations

Quantitative analysis of Th1, Th2 and TGF-β1 cytokine expression in tumor, TIL and PBL of non-small cell lung cancer patients

1998 • 139 citations

Evaluation of the interferon-γ ELISPOT-assay for quantification of peptide specific T lymphocytes from peripheral blood

1997 • 133 citations

Identification of a population of CD4+ CTL that utilizes a perforin- rather than a Fas ligand-dependent cytotoxic mechanism.

1996 • 130 citations

Clinical Staging for Cutaneous T-Cell Lymphoma

1984 • 124 citations

Alteration of the Sphingomyelin/Ceramide Pathway Is Associated with Resistance of Human Breast Carcinoma MCF7 Cells to Tumor Necrosis Factor-α-mediated Cytotoxicity

1997 • 106 citations

Human Melanoma-Reactive CD4+ and CD8+ CTL Clones Resist Fas Ligand-Induced Apoptosis and Use Fas/Fas Ligand-Independent Mechanisms for Tumor Killing

1998 • 83 citations

Resistance of MCF7 human breast carcinoma cells to TNF-induced cell death is associated with loss of p53 function

1997 • 83 citations

Human Purified Protein Derivative-Specific CD4+ T Cells Use Both CD95-Dependent and CD95-Independent Cytolytic Mechanisms

1998 • 81 citations

Resistance to TNF-alpha and adriamycin in the human breast cancer MCF-7 cell line: relationship to MDR1, MnSOD, and TNF gene expression.

1994 • 80 citations

Peripheral Blood Mononuclear Cells in Patients With Nonleukemic Cutaneous T-Cell Lymphoma

1993 • 79 citations

Pathogenesis of cutaneous T-cell lymphoma: implications for the use of recombinant cytokines and photopheresis.

1997 • 74 citations

Fas-dependent CD4⁺cytotoxic T-cell-mediated pathogenesis during virus infection

1996 • 72 citations

Fas-Independent Cytotoxicity Mediated by Human CD4+ CTL Directed Against Herpes Simplex Virus-Infected Cells

1999 • 71 citations

Functional interaction between TGF-beta and IL-12 in human primary allogeneic cytotoxicity and proliferative response.

1997 • 65 citations

Mycosis fungoides skin lesions contain CD8⁺ tumor‐infiltrating lymphocytes expressing an activated, MHC‐restricted cytotoxic T‐lymphocyte phenotype

1994 • 65 citations

Downregulation of Interleukin-12 (IL-12) Responsiveness in Human T Cells by Transforming Growth Factor-β: Relationship With IL-12 Signaling

1999 • 60 citations

CD4+ Epstein–Barr Virus-Specific Cytotoxic T-Lymphocytes from Human Umbilical Cord Blood

1999 • 60 citations

CD4 T cells kill melanoma cells by mechanisms that are independent of Fas (CD95)

1998 • 52 citations

BY55 monoclonal antibody delineates within human cord blood and bone marrow lymphocytes distinct cell subsets mediating cytotoxic activity.

1994 • 51 citations

Fas-Independent and Nonapoptotic Cytotoxicity Mediated by a Human CD4+ T-Cell Clone Directed Against an Acute Myelogenous Leukemia–Associated DEK-CAN Fusion Peptide

1999 • 44 citations

QUANTITATIVE ANALYSIS OF T HELPER 1, T HELPER 2, AND INFLAMMATORY CYTOKINE EXPRESSION IN PATIENTS AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION

1997 • 38 citations

Studies of the mechanism of cytolysis by tumour-infiltrating lymphocytes

1999 • 38 citations

T cell target 1 (TCT.1): a novel target molecule for human non-major histocompatibility complex-restricted T lymphocytes.

1990 • 35 citations

CD7-positive Sézary syndrome with a Th1 cytokine profile

1996 • 32 citations

Resistance to tumor necrosis factor induced apoptosis in vitro correlates with high metastatic capacity of cells in vivo

1999 • 12 citations

TCRAlpha/Beta and TCRGamma/Delta CD4− /CD8− HLA-DR alloreactive CTL clones do not use fas/fas ligand pathway to lyse their specific target cells

1996 • 11 citations