CD4⁺T cells eliminate MHC class II-negative cancer cellsin vivoby indirect effects of IFN-γ

Categorical Data Analysis

1991 • 9,374 citations

Categorical Data Analysis.

1991 • 3,060 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the Donor

1995 • 1,828 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

The Logic of Inductive Inference

1935 • 1,138 citations

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.

1993 • 1,127 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Fundamental Immunology

1999 • 1,011 citations

γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins

1985 • 949 citations

Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFNγ receptors

1994 • 619 citations

Interferon-γ: Biology and Role in Pathogenesis

1996 • 433 citations

Synergy between Interferon-γ and Tumor Necrosis Factor-α in Transcriptional Activation Is Mediated by Cooperation between Signal Transducer and Activator of Transcription 1 and Nuclear Factor κB

1997 • 410 citations

Tumor Cell Responses to IFNγ Affect Tumorigenicity and Response to IL-12 Therapy and Antiangiogenesis

1998 • 324 citations

Eradication of disseminated murine leukemia by chemoimmunotherapy with cyclophosphamide and adoptively transferred immune syngeneic Lyt-1+2- lymphocytes.

1981 • 317 citations

A macrophage mRNA selectively induced by gamma-interferon encodes a member of the platelet factor 4 family of cytokines.

1990 • 302 citations

Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells.

1985 • 295 citations

Mig, the Monokine Induced By Interferon-γ, Promotes Tumor Necrosis In Vivo

1997 • 251 citations

Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter.

1993 • 242 citations

A unique tumor antigen produced by a single amino acid substitution

1995 • 230 citations

Interferon-inducible protein-10 identified as a mediator of tumor necrosisin vivo

1996 • 223 citations

Antiangiogenic gene therapy

1998 • 201 citations

Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection.

1989 • 188 citations

Presence on a human melanoma of multiple antigens recognized by autologous CTL

1989 • 180 citations

Biochemical Identification of a Mutated Human Melanoma Antigen Recognized by CD4+ T Cells

1999 • 178 citations

Hyaluronan Fragments Synergize with Interferon-γ to Induce the C-X-C Chemokines Mig and Interferon-inducible Protein-10 in Mouse Macrophages

1998 • 174 citations

The role of tumor-specific Lyt-1+2- T cells in eradicating tumor cells in vivo. I. Lyt-1+2- T cells do not necessarily require recruitment of host's cytotoxic T cell precursors for implementation of in vivo immunity.

1984 • 156 citations

Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12

1998 • 151 citations

Mechanisms of syngeneic tumor rejection. Susceptibility of host-selected progressor variants to various immunological effector cells.

1982 • 135 citations

Multiple tumour-specific antigens expressed on a single tumour cell

1983 • 107 citations

Tumor antigens defined by cloned immunological probes are highly polymorphic and are not detected on autologous normal cells.

1989 • 101 citations

Major histocompatibility complex class I and unique antigen expression by murine tumors that escaped from CD8+ T-cell-dependent surveillance.

1990 • 91 citations

The Role of B Cells for in Vivo T Cell Responses to a Friend Virus-Induced Leukemia

1990 • 89 citations

Melanoma‐specific CD4+ T lymphocytes recognize human melanoma antigens processed and presented by epstein‐barr virus‐transformed B cells

1994 • 86 citations

Inhibition of cellular responsiveness to interferon-gamma (IFN gamma) induced by overexpression of inactive forms of the IFN gamma receptor

1993 • 51 citations

Biological Implications of HLA‐DR Expression in Tumours

1995 • 50 citations

Highly malignant tumor variants retain tumor-specific antigens recognized by T helper cells.

1986 • 36 citations

The Activation of L3T4+ Helper T Cells Assisting the Generation of Anti-Tumor Lyt-2+ Cytotoxic T Lymphocytes: Requirement of 1a-Positive Antigen-Presenting Cells for Processing and Presentation of Tumor Antigens

1987 • 26 citations

Rat mammary adenocarcinoma 13762 expressing IFN-gamma elicits antitumor CD4+ MHC class II-restricted T cells that are cytolytic in vitro and tumoricidal in vivo.

1995 • 23 citations

Characterization and use of monoclonal and polyclonal antibodies against the mouse interferon-γ receptor

1992 • 20 citations

Role of host antigen receptor-bearing and antigen receptor-negative cells in immune response to rat adenocarcinoma 13762.

1996 • 9 citations