Tumor Cell Responses to IFNγ Affect Tumorigenicity and Response to IL-12 Therapy and Antiangiogenesis

Genomic sequencing.

1984 • 8,343 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Analysis of single- and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange.

1977 • 2,408 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma

1982 • 1,225 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor.

1992 • 807 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.

1995 • 710 citations

Enhanced in vivo growth and resistance to rejection of tumor cells expressing dominant negative IFNγ receptors

1994 • 619 citations

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

1996 • 480 citations

GAS Elements: A Few Nucleotides with a Major Impact on Cytokine-Induced Gene Expression

1997 • 428 citations

Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis.

1998 • 419 citations

IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo.

1993 • 414 citations

Regulation of human cytolytic lymphocyte responses by interleukin-12

1992 • 331 citations

Mig, the Monokine Induced By Interferon-γ, Promotes Tumor Necrosis In Vivo

1997 • 251 citations

THE ROLE OF CXC CHEMOKINES AS REGULATORS OF ANGIOGENESIS

1995 • 240 citations

Speculations on the Role of Ultraviolet Radiation in the Development of Malignant Melanoma4

1979 • 228 citations

Effects of IL-12 on the generation of cytotoxic activity in human CD8+ T lymphocytes.

1993 • 214 citations

Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3.

1993 • 193 citations

Identification of CRG-2. An interferon-inducible mRNA predicted to encode a murine monokine.

1990 • 172 citations

Interaction between the Components of the Interferon γ Receptor Complex

1995 • 160 citations

Modifications of Vectors pEF-BOS, pcDNA1 and pcDNA3 Result in Improved Convenience and Expression

1996 • 159 citations

Specificity and longevity of antitumor immune responses induced by B7-transfected tumors.

1994 • 141 citations

B7-1 and interleukin 12 synergistically induce effective antitumor immunity.

1995 • 118 citations

Cloning and expression of the cDNA for the murine interferon gamma receptor.

1989 • 103 citations

Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-γ

1996 • 90 citations

Injection of complementary DNA encoding interleukin-12 inhibits tumor establishment at a distant site in a murine renal carcinoma model.

1996 • 68 citations

Vascular damage and delayed cell death in tumours after hyperthermia

1980 • 66 citations

Recombinant interleukin 12 enhances cellular immune responses to vaccination only after a period of suppression.

1998 • 61 citations

Inhibition of cellular responsiveness to interferon-gamma (IFN gamma) induced by overexpression of inactive forms of the IFN gamma receptor

1993 • 51 citations

Identification of Sequences in c-myc mRNA That Regulate Its Steady-State Levels

1996 • 48 citations

Involvement of T-cell subsets and natural killer (NK) cells in the growth suppression of murine fibrosarcoma cells transfected with interleukin-12 (IL-12) genes

1997 • 20 citations