Functionally inactivating point mutation in the tumor-suppressorIRF-1 gene identified in human gastric cancer

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

The multistep nature of cancer

1993 • 1,872 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Japanese classification of gastric carcinoma

1995 • 1,134 citations

Chromosome Aberrations and Cancer

1991 • 598 citations

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

1994 • 490 citations

Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated

1990 • 377 citations

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

1997 • 364 citations

Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

1996 • 326 citations

The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer.

1992 • 223 citations

Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity

1997 • 177 citations

Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA

1997 • 162 citations

Genetic alterations in human gastrointestinal cancers. The application to molecular diagnosis

1995 • 156 citations

The Molecular Basis of Oncogenes and Tumor Suppressor Genes

1995 • 140 citations

IRF-1: the transcription factor linking the interferon response and oncogenesis

1997 • 121 citations

Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation.

1994 • 115 citations

Two distinct regions of deletion on the long arm of chromosome 5 in differentiated adenocarcinomas of the stomach.

1996 • 106 citations

Characterization of the APC gene in sporadic gastric adenocarcinomas.

1996 • 21 citations