Antiangiogenic gene therapy

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis

1997 • 3,470 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression

1995 • 1,863 citations

Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance

1997 • 1,705 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis.

1995 • 699 citations

Gene Therapy for Cancer: What Have We Done and Where Are We Going?

1997 • 635 citations

Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate

1998 • 455 citations

Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2

1998 • 376 citations

Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence.

1996 • 353 citations

Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis.

1994 • 352 citations

Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth.

1997 • 257 citations

Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases.

1998 • 254 citations

Potentiation of cytotoxic cancer therapies by TNP‐470 alone and with other anti‐angiogenic agents

1994 • 241 citations

Angiostatin gene transfer: Inhibition of tumor growth in vivo by blockage of endothelial cell proliferation associated with a mitosis arrest

1998 • 239 citations

Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth

1997 • 204 citations

Critical components of the female reproductive pathway are suppressed by the angiogenesis inhibitor AGM-1470

1997 • 203 citations

Controlling the vasculature: Angiogenesis, anti-angiogenesis and vascular targeting of gene therapy

1995 • 194 citations

A human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1

1998 • 184 citations

The Development of Human Gene Therapy

1999 • 164 citations

Parenteral Gene Therapy with p53 Inhibits Human Breast TumorsIn VivoThrough a Bystander Mechanism Without Evidence of Toxicity

1997 • 138 citations

Gene therapy strategies for tumor antiangiogenesis

1998 • 126 citations

VEGF-mediated tumour angiogenesis: a new target for cancer therapy

1995 • 126 citations

Human gene therapy — an immature genie, but certainly out of the bottle

1996 • 115 citations

Gene therapy for therapeutic myocardial angiogenesis: A promising synthesis of two emerging technologies

1998 • 46 citations

Gene Therapy for Cancer

1997 • 45 citations

Gene therapy through signal transduction pathways and angiogenic growth factors as therapeutic targets in breast cancer

1994 • 38 citations

Too many scientists, too few academic jobs

1995 • 8 citations