IL-12 regulates VEGF and MMPs in a murine breast cancer model

Phase separation of integral membrane proteins in Triton X-114 solution.

1981 • 3,366 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ Production

1997 • 788 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.

1996 • 515 citations

Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal

1997 • 512 citations

Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model.

1997 • 488 citations

Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10

1996 • 480 citations

Zymography: A Single-Step Staining Method for Quantitation of Proteolytic Activity on Substrate Gels

1997 • 301 citations

Inhibition of endothelial cell proliferation by gamma-interferon.

1987 • 292 citations

Vascular endothelial growth factor regulates angiogenesis and vascular permeability in Kaposi's sarcoma.

1996 • 190 citations

Direct contact between T lymphocytes and monocytes is a major pathway for induction of metalloproteinase expression.

1994 • 180 citations

Role of Interferon-γ in Mediating the Antitumor Efficacy of Interleukin-12

1995 • 172 citations

Expression and activity of MMPS and their regulators in ovarian cancer

1994 • 168 citations

Thrombospondin-1 Modulates Angiogenesisin Vitroby Up-Regulation of Matrix Metalloproteinase-9 in Endothelial Cells

1997 • 147 citations

Regulatory mechanisms for the expression of type IV collagenases/gelatinases in murine macrophages.

1994 • 124 citations

IFN-γ Induces IL-12 mRNA Expression by a Murine Macrophage Cell Line, J774

1994 • 123 citations

A Role for the Interferon‐Inducible Protein 10 in Inhibition of Angiogenesis by Interleukin‐12

1996 • 115 citations

Leukemia inhibitory factor (LIF) inhibits angiogenesis in vitro

1995 • 98 citations

Induction of angiogenesis by smooth muscle cell‐derived factor: Possible role in neovascularization in atherosclerotic plaque

1995 • 75 citations

Expression of Vascular Endothelial Growth Factor by Cultured Endothelial Cells from Brain Microvessels

1993 • 73 citations

Interleukin-12 Inhibits Angiogenesis Induced by Human Tumor Cell Lines In Vivo

1996 • 67 citations

Multiple molecular and cellular changes associated with tumour stasis and regression during IL-12 therapy of a murine breast cancer model

1998 • 47 citations

Breast cancer; tumor neovasculature and the effect of tissue inhibitor of metalloproteinases-1 (TIMP-1) on angiogenesis.

1996 • 45 citations

Interleukin-12

1995 • 3 citations