The SH2 Domain-containing Inositol 5′-Phosphatase (SHIP) Recruits the p85 Subunit of Phosphoinositide 3-Kinase during FcγRIIb1-mediated Inhibition of B Cell Receptor Signaling

Current protocols in molecular biology

1988 • 7,584 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

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1996 • 1,333 citations

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1997 • 1,190 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor FeγRIIB

1996 • 770 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

Deletion of SHIP or SHP-1 Reveals Two Distinct Pathways for Inhibitory Signaling

1997 • 505 citations

Akt Signaling--Linking Membrane Events to Life and Death Decisions

1997 • 504 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

A Specific Product of Phosphatidylinositol 3-Kinase Directly Activates the Protein Kinase Akt through Its Pleckstrin Homology Domain

1997 • 481 citations

A Comparative Analysis of the Phosphoinositide Binding Specificity of Pleckstrin Homology Domains

1997 • 458 citations

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

1994 • 443 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.

1996 • 429 citations

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

1998 • 410 citations

SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk

1998 • 397 citations

CD19 of B Cells as a Surrogate Kinase Insert Region to Bind Phosphatidylinositol 3-Kinase

1993 • 320 citations

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

1996 • 223 citations

Crosslinking of surface immunoglobulin and Fc receptors on B lymphocytes inhibits stimulation of inositol phospholipid breakdown via the antigen receptors.

1985 • 198 citations

Fc-dependent inhibition of mouse B cell activation by whole anti-mu antibodies.

1983 • 187 citations

Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP.

1996 • 173 citations

Reconstitution of interactions between tyrosine kinases and the high affinity IgE receptor which are controlled by receptor clustering.

1995 • 159 citations

Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation

1991 • 149 citations

Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors.

1994 • 147 citations

The Src Homology 2 (SH2) Domain of SH2-containing Inositol Phosphatase (SHIP) Is Essential for Tyrosine Phosphorylation of SHIP, Its Association with Shc, and Its Induction of Apoptosis

1997 • 133 citations

The role of the PH domain in the signal-dependent membrane targeting of Sos

1997 • 131 citations

FcγRIIB1 Inhibition of BCR-Mediated Phosphoinositide Hydrolysis and Ca2+ Mobilization Is Integrated by CD19 Dephosphorylation

1997 • 121 citations

Cross-linking of IgG receptors inhibits membrane immunoglobulin-stimulated calcium influx in B lymphocytes.

1993 • 117 citations

Fc receptor off-signal in the B cell involves apoptosis.

1996 • 106 citations

Regulation of the immune response. V. An analysis of the function of the Fc portion of antibody in suppression of an immune response with respect to interaction with components of the lymphoid system.

1971 • 100 citations

Negative Signaling Pathways of the Killer Cell Inhibitory Receptor and FcγRIIb1 Require Distinct Phosphatases

1997 • 94 citations

Co-ligation of the Antigen and Fc Receptors Gives Rise to the Selective Modulation of Intracellular Signaling in B Cells

1997 • 94 citations

Negative signaling in B cells: SHIP Grbs Shc

1997 • 81 citations

Protein-tyrosine Phosphatase SHP-1 Is Dispensable for FcγRIIB-mediated Inhibition of B Cell Antigen Receptor Activation

1997 • 73 citations

Phosphatidylinositol 3,4,5-trisphosphate is a substrate for the 75 kDa inositol polyphosphate 5-phosphatase and a novel 5-phosphatase which forms a complex with the p85/p110 form of phosphoinositide 3-kinase.

1995 • 73 citations

The B lymphocyte calcium response to anti-Ig is diminished by membrane immunoglobulin cross-linkage to the Fc gamma receptor.

1987 • 71 citations