Metabolic Activation of Drugs to Toxic Substances

Bromobenzene-Induced Liver Necrosis. Protective Role of Glutathione and Evidence for 3,4-Bromobenzene Oxide as the Hepatotoxic Metabolite

1974 • 3,074 citations

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

1973 • 1,717 citations

Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.

1973 • 1,467 citations

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

1970 • 1,464 citations

Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.

1973 • 1,174 citations

Carcinogenic Nitroso Compounds

1967 • 1,109 citations

Acetaminophen-induced Hepatic Necrosis

1974 • 1,021 citations

Arene oxides and the NIH shift: The metabolism, toxicity and carcinogenicity of aromatic compounds

1972 • 593 citations

Acetaminophen‐induced hepatic injury: Protective role of glutathione in man and rationale for therapy

1974 • 523 citations

Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.

1973 • 500 citations

Mechanisms of chemical carcinogenesis: nature of proximate carcinogens and interactions with macromolecules.

1966 • 489 citations

Possible Mechanism of Liver Necrosis Caused by Aromatic Organic Compounds

1971 • 382 citations

Biochemical Mechanisms of Drug Toxicity

1974 • 337 citations

Biochemical formation and pharmacological, toxicological, and pathological properties of hydroxylamines and hydroxamic acids.

1973 • 328 citations

Enzyme-catalysed conjugations of glutathione with unsaturated compounds

1967 • 324 citations

DRUG-INDUCED HEMOLYTIC ANEMIA

1959 • 265 citations

SUCCESSFUL TREATMENT OF SEVERE PARACETAMOL OVERDOSAGE WITH CYSTEAMINE

1974 • 237 citations

SPECIES DIFFERENCES IN THE METABOLISM OF IMIPRAMINE AND DESMETHYLIMIPRAMINE (DMI).

1964 • 234 citations

Pharmacogenetics. Heredity and the Response to Drugs.

1963 • 233 citations

Role of detoxifying enzymes in bromobenzene-induced liver necrosis.

1973 • 212 citations

The biochemical production of ferrihemoglobin-forming derivatives from aromatic amines, and mechanisms of ferrihemoglobin formation.

1966 • 196 citations

Specific Carcinogenic and Teratogenic Effects of ‘Indirect’ Alkylating Methyl and Ethyl compounds, and their Dependency on Stages of Ontogenic Developments

1973 • 173 citations

Isoniazid Hepatitis

1973 • 162 citations

Drug metabolism as a cause of drug toxicity.

1973 • 133 citations

2,3-Dihydro-2,3-dihydroxy-aflatoxin B1: An acid hydrolysis product of an RNA-aflatoxin B1 adduct formed by hamster and rat liver microsomes in vitro

1973 • 128 citations

The role of cytochrome P-450 in N-hydroxylation of 2-acetylaminofluorene.

1973 • 116 citations

Phenobarbital-induced protection against toxicity of toluene and benzene in the rat

1971 • 116 citations

Potentiation by Previous Drug Therapy of Hepatotoxicity following Paracetamol Overdosage

1973 • 115 citations

Hepatic necrosis caused by furosemide

1974 • 101 citations

Biochemistry of carcinogenesis.

1968 • 93 citations

Enhancement by potent diuretics of renal tubular necrosis induced by cephaloridine

1970 • 85 citations

Inhibition of phenacetin- and acetanilide-induced methemoglobinemia in the rat by the carboxylesterase inhibitor Bis-[p-nitrophenyl] phosphate

1969 • 84 citations

Studies on the metabolic basis for the genetically determined capacities for isoniazid inactivation in man.

1965 • 81 citations

Toxicity from rifampicin plus isoniazid and rifampicin plus ethambutol therapy

1971 • 77 citations

Induction of the Unspecific Microsomal Hydroxylase in the Human Liver

2015 • 75 citations

Effect of Rifampicin and Isoniazid on Liver Function

1972 • 74 citations

Sulphadimidine Acetylation Test for Classification of Patients as Slow or Rapid Inactivators of Isoniazid

1970 • 73 citations

A Lung Oedema Factor from Mouldy Sweet Potatoes (Ipomoea batatas)

1971 • 64 citations

Phenobarbital-mediated increase in ring- and N-hydroxylation of the carcinogen N-2-fluorenylacetamide, and decrease in amounts bound to liver deoxyribonucleic acid

1972 • 59 citations

Icterus and Febrile Reactions in Response to Isonicotinic Acid Hydrazine

1959 • 45 citations

Aerospace Problems in Pharmacology and Toxicology

1970 • 43 citations

Detection of 5-(3, 4-Dihydroxy-1, 5-Cyclohexadien-1-Yl) -5-Phenylsydantoin as a Major Metabolite of 5, 5-Diphenylhydantoin (Dilantin) in the Newborn Human

1971 • 38 citations

TOXIC HEPATIC NECROSIS (HEPATITIS) DUE TO ISONIAZID: REPORT OF A CASE WITH CIRRHOSIS AND DEATH DUE TO HEMORRHAGE FROM ESOPHAGEAL VARICES

1959 • 38 citations

Cephaloridine and the Kidneys

1970 • 37 citations

Hepatotoxicity in Rifampin-Isoniazid Treated Patients Related to Their Rate of Isoniazid Inactivation

1972 • 28 citations

Drug Responses in Man.

1968 • 23 citations

Aspects of the Metabolism of Isoniazid and Acetylisoniazid in the Human and the Dog

1962 • 22 citations

�ber die harnausscheidung von furosemid bei gesunden und kranken mit lebercirrhose

1970 • 21 citations

Detection of a 5-(3,4-dihydroxy-1,5-cyclohexadien-1-yl)-metabolite of phenobarbital and mephobarbital in rat, guinea pig and human.

1972 • 20 citations

Biochemistry of Carcinogenesis

1967 • 20 citations

Modification by para-aminosalicylic acid and sulfamethazine of the isoniazid inactivation in man.

1969 • 13 citations

Drug-Induced Hemolytic Anemia

1963 • 12 citations

Rifampin plus Isoniazid in Initial Therapy of Pulmonary Tuberculosis and Rifampin and Ethambutol in Retreatment Cases

1972 • 12 citations

The effect of prior dosing with phenobarbitone and -diethylaminoethyl diphenylpropyl acetate (SKF525A) on the toxicity and liver lesion caused by ngaione in the mouse.

1972 • 11 citations

[Idiosyncrasy and intolerance].

1952 • 5 citations

Toxicity to Para-aminosalicylic Acid and Isoniazid

1960 • 4 citations

Effect of pretreatment with phenobarbitone and CS2 on lesions caused in the mouse by 3-hydroxymethyl furan (N,N-diethyl)-carbamate.

1973 • 2 citations

Deleted Work

1955 • 0 citations