Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.

1973 • 1,174 citations

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

1982 • 893 citations

A scheme for the colorimetric determination of microgram amounts of thiols

1958 • 754 citations

Intracellular production of superoxide radical and of hydrogen peroxide by redox active compounds

1979 • 595 citations

Bleb Formation in Hepatocytes During Drug Metabolism Is Caused by Disturbances in Thiol and Calcium Ion Homeostasis

1982 • 553 citations

Hormonal effects on calcium homeostasis in isolated hepatocytes.

1980 • 441 citations

The Regulation of Intracellular Calcium

1978 • 415 citations

Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes

1984 • 411 citations

Changes in free cytosolic Ca2+ in hepatocytes following alpha 1-adrenergic stimulation. Studies on Quin-2-loaded hepatocytes.

1983 • 375 citations

The effects of glucose and of potassium ions on the interconversion of the two forms of glycogen phosphorylase and of glycogen synthetase in isolated rat liver preparations

1975 • 357 citations

Energy-dependent calcium sequestration activity in rat liver microsomes.

1975 • 342 citations

Biological disulfides: the third messenger? Modulation of phosphofructokinase activity by thiol/disulfide exchange.

1982 • 265 citations

Adriamycin stimulated superoxide formation in submitochondrial particles

1977 • 256 citations

Enzymatic Basis of Detoxication

1981 • 244 citations

Microsomes, drug oxidations, and drug toxicity

1982 • 187 citations

Inhibition of ATP-dependent microsomal Ca2+ sequestration during oxidative stress and its prevention by glutathione.

1983 • 176 citations

Critical role of sulfhydryl group(s) in ATP‐dependent Ca²⁺ sequestration by the plasma membrane fraction from rat liver

1983 • 172 citations

A Hypothesis for the Role of Dithiol‐Disulfide Interchange in Solute Transport and Energy‐Transducing Processes

1982 • 143 citations

Increase in cytosolic Ca²⁺ concentration during t‐butyl hydroperoxide metabolism by isolated hepatocytes involves NADPH oxidation and mobilization of intracellular Ca²⁺ stores

1984 • 107 citations

Calcium Uptake in Isolated Hepatic Plasma‐Membrane Vesicles

1982 • 107 citations

Calcium transport and phosphorylated intermediate of (Ca2+ + Mg2+)-ATPase in plasma membranes of rat liver.

1983 • 100 citations

An essential role of cytosolic thioltransferase in protection of pyruvate kinase from rabbit liver against oxidative inactivation

1983 • 57 citations

Role of phospholipid hydrolysis in the mechanism of toxic cell death by calcium and ionophore A23187

1982 • 53 citations

Daunorubicin-stimulated reactive oxygen metabolism in cardiac sarcosomes

1981 • 38 citations

Effects of sulfhydryl and other reagents on the diffusional permeability of dog erythrocytes to small solutes

1983 • 12 citations