Metabolic activation and hepatotoxicity

A fluorometric method for determination of oxidized and reduced glutathione in tissues

1976 • 4,013 citations

10 Methoden der enzymatischen Analyse

2019 • 3,602 citations

Bromobenzene-Induced Liver Necrosis. Protective Role of Glutathione and Evidence for 3,4-Bromobenzene Oxide as the Hepatotoxic Metabolite

1974 • 3,074 citations

Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.

1973 • 1,717 citations

[4] Isolation and use of liver cells

1978 • 1,230 citations

Glutathione and Related γ-Glutamyl Compounds: Biosynthesis and Utilization

1976 • 846 citations

A scheme for the colorimetric determination of microgram amounts of thiols

1958 • 754 citations

ENZYME-STRUCTURE RELATIONSHIPS IN THE ENDOPLASMIC RETICULUM OF RAT LIVER

1962 • 718 citations

Biological Reactive Intermediates

1977 • 597 citations

TREATMENT OF PARACETAMOL (ACETAMINOPHEN) POISONING WITH N-ACETYLCYSTEINE

1977 • 439 citations

Enzyme-catalysed conjugations of glutathione with unsaturated compounds

1967 • 324 citations

Regulation of Hepatic Metabolism

1976 • 314 citations

HAEMOLYTIC ANAEMIA AND ACUTE RENAL DISEASE.

1965 • 309 citations

The Molecular Biology of Cancer

1974 • 298 citations

Metabolic Activation of Drugs to Toxic Substances

1975 • 281 citations

SUCCESSFUL TREATMENT OF SEVERE PARACETAMOL OVERDOSAGE WITH CYSTEAMINE

1974 • 237 citations

Role of detoxifying enzymes in bromobenzene-induced liver necrosis.

1973 • 212 citations

A Correlation between Glutathione Levels and Cellular Damage in Isolated Hepatocytes

1977 • 204 citations

The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures

1975 • 161 citations

The role of methionine in glutathione biosynthesis by isolated hepatocytes

1977 • 159 citations

Maintenance of glutathione content is isolated hepatocyctes

1978 • 158 citations

Conversion of naphthalene to trans-naphthalene dihydrodiol: Evidence for the presence of a coupled aryl monooxygenase-epoxide hydrase system in hepatic microsomes

1972 • 151 citations

Bromobenzene Metabolism and Hepatic Necrosis

1971 • 141 citations

Incorporation of radioactive amino acids into protein in isolated rat hepatocytes

1976 • 124 citations

A Study of Drug Metabolism Linked to Cytochrome P‐450 in Isolated Rat‐Liver Cells

1974 • 103 citations

Quantitative determination of the glutathione, cysteine, and N-acetyl cysteine conjugates of acetaminophen by high-pressure liquid chromatography

1977 • 87 citations

Biochemical Mechanism of Hepatic Necrosis Induced by Aromatic Hydrocarbons

1973 • 78 citations

Effects of Trypsin on the Electron Transport Systems of Liver Microsomes

1969 • 62 citations

Metabolic activation and hepatotoxicity

1978 • 62 citations

Isolated rat hepatocytes as an experimental tool in the study of cell injury. Effect of anoxia

1976 • 47 citations

Biological Reactive Intermediates: formation, Toxicity and Inactivation

1978 • 46 citations

THE METABOLISM OF SULFUR

1932 • 33 citations

STUDIES ON THE MERCAPTURIC ACID SYNTHESIS IN ANIMALS

1937 • 29 citations

Characterization of a penta- and an octasaccharide from urine of a patient with juvenile GM1-gangliosidosis

1978 • 26 citations

Alkylation of coenzymes and the acute effects of alkylating hepatotoxins

1976 • 23 citations

Biochemical studies on the mechanism of action of liver poisons III. Depletion of liver glutathione in ethionine poisoning

1974 • 18 citations

Ciba Foundation Symposium ‐ Drug Responses in Man

1967 • 13 citations

Studies in the Sulphur Metabolism of the Dog

1927 • 12 citations