Posttranslational Modifications and Receptor-Associated Proteins in AMPA Receptor Trafficking and Synaptic Plasticity

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

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Cloned Glutamate Receptors

1994 • 3,989 citations

LTP and LTD

2004 • 3,754 citations

Glutamate receptor ion channels

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Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

AMPA Receptor Trafficking and Synaptic Plasticity

2002 • 2,540 citations

Neurotrophins and Neuronal Plasticity

1995 • 1,937 citations

Long-Term Potentiation and Memory

2004 • 1,888 citations

Neurotrophins as synaptic modulators

2001 • 1,773 citations

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

1996 • 1,680 citations

Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

2000 • 1,507 citations

MAPK cascade signalling and synaptic plasticity

2004 • 1,384 citations

Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation

1999 • 1,272 citations

Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

1993 • 1,212 citations

The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein

1992 • 1,180 citations

AMPA Receptor Trafficking at Excitatory Synapses

2003 • 1,121 citations

The MAPK cascade is required for mammalian associative learning

1998 • 1,086 citations

Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

2000 • 1,086 citations

Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

2000 • 1,085 citations

Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting

2000 • 1,076 citations

Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons

2001 • 1,073 citations

The Biochemistry of Memory: A New and Specific Hypothesis

1984 • 1,048 citations

Receptor trafficking and synaptic plasticity

2004 • 995 citations

AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss

2006 • 982 citations

Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system

2003 • 972 citations

Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions

2001 • 966 citations

Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2

2000 • 933 citations

Rapid Actin-Based Plasticity in Dendritic Spines

1998 • 920 citations

Differential Regulation of AMPA Receptor and GABA Receptor Trafficking by Tumor Necrosis Factor-α

2005 • 912 citations

PKA phosphorylation of AMPA receptor subunits controls synaptic trafficking underlying plasticity

2003 • 871 citations

GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors

1997 • 866 citations

Storage of Spatial Information by the Maintenance Mechanism of LTP

2006 • 840 citations

Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons

1996 • 835 citations

Mutation of the Angelman Ubiquitin Ligase in Mice Causes Increased Cytoplasmic p53 and Deficits of Contextual Learning and Long-Term Potentiation

1998 • 820 citations

Actin-Based Plasticity in Dendritic Spines

2000 • 813 citations

Characterization of Multiple Phosphorylation Sites on the AMPA Receptor GluR1 Subunit

1996 • 802 citations

Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning

1999 • 794 citations

Phosphorylation of the AMPA Receptor GluR1 Subunit Is Required for Synaptic Plasticity and Retention of Spatial Memory

2003 • 782 citations

Regulation of AMPA receptors during synaptic plasticity

2002 • 757 citations

Postsynaptic Receptor Trafficking Underlying a Form of Associative Learning

2005 • 750 citations

Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing

1994 • 735 citations

Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number

2002 • 729 citations

Postsynaptic Signaling and Plasticity Mechanisms

2002 • 713 citations

Recycling Endosomes Supply AMPA Receptors for LTP

2004 • 712 citations

Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization

2000 • 687 citations

Hippocampal LTP Is Accompanied by Enhanced F-Actin Content within the Dendritic Spine that Is Essential for Late LTP Maintenance In Vivo

2003 • 685 citations

Sequestosome 1/p62 Is a Polyubiquitin Chain Binding Protein Involved in Ubiquitin Proteasome Degradation

2004 • 673 citations

Structure of a glutamate-receptor ligand-binding core in complex with kainate

1998 • 672 citations

Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons

2001 • 657 citations

Synaptic plasticity in the hippocampus: LTP and LTD

1994 • 653 citations

SNAPs, a family of NSF attachment proteins involved in intracellular membrane fusion in animals and yeast

1990 • 578 citations

Glutamate-operated channels: Developmentally early and mature forms arise by alternative splicing

1991 • 560 citations

Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

2000 • 550 citations

Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression

2003 • 548 citations

Microtubule-Based Transport Systems in Neurons: The Roles of Kinesins and Dyneins

2000 • 544 citations

Phosphorylation of the AMPA Receptor Subunit GluR2 Differentially Regulates Its Interaction with PDZ Domain-Containing Proteins

2000 • 542 citations

NSF Binding to GluR2 Regulates Synaptic Transmission

1998 • 542 citations

Clustering of AMPA Receptors by the Synaptic PDZ Domain–Containing Protein PICK1

1999 • 540 citations

Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins

2003 • 518 citations

Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites

2002 • 517 citations

Adaptors for Clathrin-Mediated Traffic

1999 • 500 citations

Single-Channel Properties of Recombinant AMPA Receptors Depend on RNA Editing, Splice Variation, and Subunit Composition

1997 • 484 citations

Expression of Cerebellar Long-Term Depression Requires Postsynaptic Clathrin-Mediated Endocytosis

2000 • 483 citations

Glutamate Receptor Exocytosis and Spine Enlargement during Chemically Induced Long-Term Potentiation

2006 • 478 citations

Stargazin modulates AMPA receptor gating and trafficking by distinct domains

2005 • 475 citations

Plasticity-Induced Growth of Dendritic Spines by Exocytic Trafficking from Recycling Endosomes

2006 • 474 citations

Targeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex

2000 • 463 citations

PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands

1998 • 455 citations

Extrasynaptic Membrane Trafficking Regulated by GluR1 Serine 845 Phosphorylation Primes AMPA Receptors for Long-term Potentiation

2005 • 454 citations

Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation.

1993 • 439 citations

Clathrin Adaptor AP2 and NSF Interact with Overlapping Sites of GluR2 and Play Distinct Roles in AMPA Receptor Trafficking and Hippocampal LTD

2002 • 437 citations

Role of ampa receptor endocytosis in synaptic plasticity

2001 • 436 citations

Phosphorylation of the α-Amino-3-hydroxy-5-methylisoxazole4-propionic Acid Receptor GluR1 Subunit by Calcium/ Calmodulin-dependent Kinase II

1997 • 434 citations

Non-traditional Functions of Ubiquitin and Ubiquitin-binding Proteins

2003 • 430 citations

Protein kinase Mζ is necessary and sufficient for LTP maintenance

2002 • 427 citations

Postnatal synaptic potentiation: Delivery of GluR4-containing AMPA receptors by spontaneous activity

2000 • 427 citations

Dynamin-dependent endocytosis of ionotropic glutamate receptors

1999 • 425 citations

Postsynaptic Membrane Fusion and Long-Term Potentiation

1998 • 417 citations

SAP97 Is Associated with the α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor GluR1 Subunit

1998 • 415 citations

Role for brain-derived neurotrophic factor in learning and memory

2002 • 400 citations

The interaction of p62 with RIP links the atypical PKCs to NF-kappa B activation

1999 • 394 citations

Ubiquitination-dependent mechanisms regulate synaptic growth and function

2001 • 383 citations

LTP mechanisms: from silence to four-lane traffic

2000 • 382 citations

Auxiliary Subunits Assist AMPA-Type Glutamate Receptors

2006 • 368 citations

Synaptic Incorporation of AMPA Receptors during LTP Is Controlled by a PKC Phosphorylation Site on GluR1

2006 • 362 citations

The AMPA Receptor GluR2 C Terminus Can Mediate a Reversible, ATP-Dependent Interaction with NSF and α- and β-SNAPs

1998 • 355 citations

Novel Anchorage of GluR2/3 to the Postsynaptic Density by the AMPA Receptor–Binding Protein ABP

1998 • 354 citations

EphrinB Ligands Recruit GRIP Family PDZ Adaptor Proteins into Raft Membrane Microdomains

1999 • 345 citations

Spatial memory dissociations in mice lacking GluR1

2002 • 342 citations

ORGANELLES AND TRAFFICKING MACHINERY FOR POSTSYNAPTIC PLASTICITY

2006 • 340 citations

RNA Editing at Arg607 Controls AMPA Receptor Exit from the Endoplasmic Reticulum

2002 • 338 citations

Requirement of AMPA Receptor GluR2 Phosphorylation for Cerebellar Long-Term Depression

2003 • 333 citations

Bidirectional Synaptic Plasticity Regulated by Phosphorylation of Stargazin-like TARPs

2005 • 331 citations

Synaptic Plasticity and AMPA Receptor Trafficking

2003 • 327 citations

Presynaptic BDNF Required for a Presynaptic but Not Postsynaptic Component of LTP at Hippocampal CA1-CA3 Synapses

2003 • 325 citations

PICK1 Targets Activated Protein Kinase Cα to AMPA Receptor Clusters in Spines of Hippocampal Neurons and Reduces Surface Levels of the AMPA-Type Glutamate Receptor Subunit 2

2001 • 322 citations

Signal integration and diversification through the p62 scaffold protein

2006 • 314 citations

Mammalian ionotropic glutamate receptors

1993 • 312 citations

Receptor trafficking and the plasticity of excitatory synapses

2002 • 304 citations

Surface Expression of AMPA Receptors in Hippocampal Neurons Is Regulated by an NSF-Dependent Mechanism

1999 • 301 citations

Regulation of AMPA Receptor GluR1 Subunit Surface Expression by a 4.1N-Linked Actin Cytoskeletal Association

2000 • 295 citations

Ubiquitin and AP180 Regulate the Abundance of GLR-1 Glutamate Receptors at Postsynaptic Elements in C. elegans

2002 • 293 citations

Subunit Rules Governing the Sorting of Internalized AMPA Receptors in Hippocampal Neurons

2004 • 277 citations

Differential Regulation of AMPA Receptor Subunit Trafficking by Palmitoylation of Two Distinct Sites

2005 • 275 citations

LIN-10 Is a Shared Component of the Polarized Protein Localization Pathways in Neurons and Epithelia

1998 • 271 citations

The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn

1999 • 271 citations

Protein Kinase Mζ Synthesis from a Brain mRNA Encoding an Independent Protein Kinase Cζ Catalytic Domain

2003 • 267 citations

Lysine 63 Polyubiquitination of the Nerve Growth Factor Receptor TrkA Directs Internalization and Signaling

2005 • 267 citations

Synapse-Associated Protein 97 Selectively Associates with a Subset of AMPA Receptors Early in their Biosynthetic Pathway

2001 • 259 citations

Calcium-Permeable AMPA Receptor Plasticity Is Mediated by Subunit-Specific Interactions with PICK1 and NSF

2005 • 251 citations

Interaction between GRIP and Liprin-α/SYD2 Is Required for AMPA Receptor Targeting

2002 • 249 citations

The Ubiquitin Proteasome System Acutely Regulates Presynaptic Protein Turnover and Synaptic Efficacy

2003 • 245 citations

Brain-derived Neurotrophic Factor Regulates the Expression and Synaptic Delivery ofα-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor Subunits in Hippocampal Neurons

2007 • 238 citations

AMPA receptor trafficking and long-term potentiation

2003 • 237 citations

Photoinactivation of Native AMPA Receptors Reveals Their Real-Time Trafficking

2005 • 236 citations

Characterization of the Glutamate Receptor-Interacting Proteins GRIP1 and GRIP2

1999 • 231 citations

Dynamic Interaction of Stargazin-like TARPs with Cycling AMPA Receptors at Synapses

2004 • 228 citations

Glutamate Receptor Subunit 2 Serine 880 Phosphorylation Modulates Synaptic Transmission and Mediates Plasticity in CA1 Pyramidal Cells

2003 • 223 citations

Persistent Phosphorylation by Protein Kinase Mζ Maintains Late-Phase Long-Term Potentiation

2005 • 221 citations

Phosphatidylinositol 3-Kinase Regulates the Induction of Long-Term Potentiation through Extracellular Signal-Related Kinase-Independent Mechanisms

2003 • 219 citations

PICK1 Interacts with ABP/GRIP to Regulate AMPA Receptor Trafficking

2005 • 219 citations

Regulation of GluR1 by the A-Kinase Anchoring Protein 79 (AKAP79) Signaling Complex Shares Properties with Long-Term Depression

2002 • 216 citations

Interaction of protein kinase C ζ with ZIP, a novel protein kinase C-binding protein

1997 • 214 citations

The Molecular Pharmacology and Cell Biology of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptors

2005 • 208 citations

Ubiquitin-Mediated Proteasome Activity Is Required for Agonist-Induced Endocytosis of GluRs

2003 • 207 citations

Association of the Kinesin Motor KIF1A with the Multimodular Protein Liprin-α

2003 • 205 citations

AMPA Receptor Trafficking and the Control of Synaptic Transmission

2001 • 199 citations

The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin

2004 • 199 citations

Molecular cloning and development analysis of a new glutamate receptor subunit isoform in cerebellum

1992 • 194 citations

NSF ATPase and α-/β-SNAPs Disassemble the AMPA Receptor-PICK1 Complex

2002 • 189 citations

Tyrosine Phosphorylation and Regulation of the AMPA Receptor by Src Family Tyrosine Kinases

2004 • 178 citations

A possible docking and fusion particle for synaptic transmission

1995 • 177 citations

UBIQUITIN-DEPENDENT REGULATION OF THE SYNAPSE

2004 • 173 citations

β1-Integrins Are Required for Hippocampal AMPA Receptor-Dependent Synaptic Transmission, Synaptic Plasticity, and Working Memory

2006 • 162 citations

Interaction between Liprin-α and GIT1 Is Required for AMPA Receptor Targeting

2003 • 160 citations

Ubiquitin and Protein Turnover in Synapse Function

2005 • 155 citations

AMPA receptor-mediated regulation of a Gi-protein in cortical neurons

1997 • 155 citations

Ephrins and their receptors: a repulsive topic?

1997 • 154 citations

GRASP-1

2000 • 153 citations

Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination

2005 • 152 citations

Ubiquitin and the synapse

2002 • 151 citations

Regulation of Protein Kinase Mζ Synthesis by Multiple Kinases in Long-Term Potentiation

2007 • 147 citations

SNAP-mediated protein–protein interactions essential for neurotransmitter release

1995 • 146 citations

A Novel Neuron-Enriched Homolog of the Erythrocyte Membrane Cytoskeletal Protein 4.1

1999 • 141 citations

The organization of the gene for the functionally dominant alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluR-B

1994 • 136 citations

Protein kinase Mζ enhances excitatory synaptic transmission by increasing the number of active postsynaptic AMPA receptors

2006 • 134 citations

Differential Stimulation of PKC Phosphorylation of Potassium Channels by ZIP1 and ZIP2

1999 • 130 citations

Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking

2003 • 118 citations

N-Glycosylation Is Not a Prerequisite for Glutamate Receptor Function but Is Essential for Lectin Modulation

1997 • 114 citations

Molecular constituents of neuronal AMPA receptors

2005 • 112 citations

Interactions between NEEP21, GRIP1 and GluR2 regulate sorting and recycling of the glutamate receptor subunit GluR2

2005 • 110 citations

CaMKII-dependent Phosphorylation Regulates SAP97/NR2A Interaction

2003 • 104 citations

Surface Expression of GluR-D AMPA Receptor Is Dependent on an Interaction between Its C-Terminal Domain and a 4.1 Protein

2003 • 104 citations

Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1

2005 • 102 citations

SAP97 concentrates at the postsynaptic density in cerebral cortex

2000 • 100 citations

Calcium/Calmodulin-dependent Protein Kinase II Phosphorylation Drives Synapse-associated Protein 97 into Spines

2004 • 95 citations

Selective Binding of Synapse-associated Protein 97 to GluR-A α-Amino-5-hydroxy-3-methyl-4-isoxazole Propionate Receptor Subunit Is Determined by a Novel Sequence Motif

2002 • 91 citations

A proteasome-sensitive connection between PSD-95 and GluR1 endocytosis

2004 • 89 citations

KEL-8 Is a Substrate Receptor for CUL3-dependent Ubiquitin Ligase That Regulates Synaptic Glutamate Receptor Turnover

2006 • 88 citations

AMPA Receptor Trafficking: A Road Map for Synaptic Plasticity

2003 • 83 citations

Interactions between AMPA receptors and intracellular proteins

2000 • 82 citations

Characterization of Phosphorylation Sites on the Glutamate Receptor 4 Subunit of the AMPA Receptors

1999 • 82 citations

Genes, synapses, and long-term memory

1997 • 82 citations

In vitro analysis of the binding of ADAR2 to the pre-mRNA encoding the GluR-B R/G site

2000 • 81 citations

AMPA receptor trafficking and synaptic plasticity: major unanswered questions

2003 • 75 citations

New Roles for Ubiquitin in the Assembly and Function of Neuronal Circuits

2002 • 72 citations

Identification of protein kinase C phosphorylation sites within the AMPA receptor GluR2 subunit

2001 • 71 citations

Synchronized Neural Activity in the Drosophila Memory Centers and Its Modulation by amnesiac

2001 • 69 citations

AMPA receptor phosphorylation during synaptic plasticity

2005 • 69 citations

Stargazin interacts functionally with the AMPA receptor glutamate-binding module

2006 • 64 citations

ZIP3, a New Splice Variant of the PKC-ζ-interacting Protein Family, Binds to GABAC Receptors, PKC-ζ, and Kvβ2

2003 • 57 citations

Proteins interactions implicated in AMPA receptor trafficking: a clear destination and an improving route map

2003 • 57 citations

Calnexin and the Immunoglobulin Binding Protein (BiP) Coimmunoprecipitate with AMPA Receptors

1999 • 56 citations

Differential expression of atypical PKCs in the adult mouse brain

2004 • 53 citations

Atypical Protein Kinase C in Neurodegenerative Disease I

2006 • 51 citations

Protein Kinase Cγ Associates Directly with the GluR4 α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate Receptor Subunit

2003 • 51 citations

PDZ Domain-dependent Suppression of NF-κB/p65-induced Aβ42 Production by a Neuron-specific X11-like Protein

2000 • 49 citations

The Adapter Protein ZIP Binds Grb14 and Regulates Its Inhibitory Action on Insulin Signaling by Recruiting Protein Kinase Cζ

2002 • 41 citations

AMPA receptor phosphorylation during synaptic plasticity

2005 • 39 citations

The PDZ Domain of PICK1 Differentially Accepts Protein Kinase C-α and GluR2 as Interacting Ligands

2004 • 36 citations

The PDZ domains of mLin-10 regulate its trans-Golgi network targeting and the surface expression of AMPA receptors

2003 • 35 citations

Glutamate Receptor-interacting Protein 1 Protein Binds to the Microtubule-associated Protein

2004 • 27 citations

Bass, B. L. et al. A standardized nomenclature for adenosine deaminases that act on RNA. RNA 3, 947-949

1997 • 19 citations

Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody

2002 • 16 citations

Use of the two-hybrid system to find novel proteins that interact with α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor subunits

1997 • 14 citations

Occurrence of dentate granule cell LTP without proximal dendritic Ca2+ increase

1999 • 3 citations