Ephrins and their receptors: a repulsive topic?

Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

1994 • 985 citations

Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis

1996 • 851 citations

In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases

1995 • 849 citations

Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map

1995 • 740 citations

Ligands for EPH-Related Receptor Tyrosine Kinases that Require Membrane Attachment or Clustering for Activity

1994 • 720 citations

Nuk Controls Pathfinding of Commissural Axons in the Mammalian Central Nervous System

1996 • 536 citations

Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands

1996 • 526 citations

Eph Family Transmembrane Ligands Can Mediate Repulsive Guidance of Trunk Neural Crest Migration and Motor Axon Outgrowth

1997 • 477 citations

A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene

1987 • 430 citations

Topographically Specific Effects of ELF-1 on Retinal Axon Guidance In Vitro and Retinal Axon Mapping In Vivo

1996 • 418 citations

Tyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors

1997 • 394 citations

Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration

1997 • 389 citations

Role of B61, the Ligand for the Eck Receptor Tyrosine Kinase, in TNF-α-Induced Angiogenesis

1995 • 368 citations

The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells

1997 • 343 citations

Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation.

1996 • 334 citations

Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases

1994 • 332 citations

Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain

1995 • 315 citations

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

1994 • 303 citations

Rho: theme and variations

1996 • 290 citations

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

1997 • 276 citations

Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation

1995 • 261 citations

Drosophila Photoreceptor Axon Guidance and Targeting Requires the Dreadlocks SH2/SH3 Adapter Protein

1996 • 248 citations

B61 is a ligand for the ECK receptor protein-tyrosine kinase

1994 • 239 citations

cDNA Cloning and Characterization of eck, an Epithelial Cell Receptor Protein-Tyrosine Kinase in the eph/elk Family of Protein Kinases

1990 • 234 citations

A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm

1992 • 226 citations

Distinct and Overlapping Expression Patterns of Ligands for Eph-Related Receptor Tyrosine Kinases during Mouse Embryogenesis

1996 • 215 citations

The tyrosine kinase connection: how GPI-anchored proteins activate T cells

1993 • 198 citations

Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps

1995 • 187 citations

Rostral optic tectum acquires caudal characteristics following ectopic Engrailed expression

1996 • 179 citations

Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis.

1994 • 174 citations

Efficient Cloning of cDNAs of Retinoic Acid-Responsive Genes in P19 Embryonal Carcinoma Cells and Characterization of a Novel Mouse Gene, Stra1 (Mouse LERK-2/Eplg2)

1995 • 169 citations

Detection of Ligands in Regions Anatomically Connected to Neurons Expressing the Eph Receptor Bsk: Potential Roles in Neuron–Target Interaction

1996 • 159 citations

ELF-2, a New Member of the Eph Ligand Family, Is Segmentally Expressed in Mouse Embryos in the Region of the Hindbrain and Newly Forming Somites

1995 • 155 citations

Thyroid Hormone Modulates the Interaction between Iron Regulatory Proteins and the Ferritin mRNA Iron-responsive Element

1996 • 154 citations

Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity.

1994 • 151 citations

Novel protein-tyrosine kinase cDNAs related to fps/fes and eph cloned using anti-phosphotyrosine antibody.

1988 • 151 citations

Regulation of topographic projection in the brain: Elf-1 in the hippocamposeptal system.

1996 • 147 citations

Ligand Activation of ELK Receptor Tyrosine Kinase Promotes Its Association with Grb10 and Grb2 in Vascular Endothelial Cells

1996 • 145 citations

Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.

1994 • 141 citations

Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases.

1995 • 141 citations

Eph Family Receptors and Their Ligands Distribute in Opposing Gradients in the Developing Mouse Retina

1996 • 137 citations

Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain

1994 • 135 citations

The cloning of Grb10 reveals a new family of SH2 domain proteins.

1995 • 130 citations

The Rho's progress: a potential role during neuritogenesis for the Rho family of GTPases

1995 • 129 citations

Characterization of a Novel Src-like Adapter Protein That Associates with the Eck Receptor Tyrosine Kinase

1995 • 127 citations

Two Eph receptor tyrosine kinase ligands control axon growth and may be involved in the creation of the retinotectal map in the zebrafish

1997 • 125 citations

Polarized Expression of the Receptor Protein Tyrosine Kinase Cek5 in the Developing Avian Visual System

1995 • 125 citations

Elk-L3, a novel transmembrane ligand for the Eph family of receptor tyrosine kinases, expressed in embryonic floor plate, roof plate and hindbrain segments.

1996 • 115 citations

ELK and LERK-2 in developing kidney and microvascular endothelial assembly.

1996 • 114 citations

Function of the Eph-related kinase rtk1 in patterning of the zebrafish forebrain

1996 • 113 citations

A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn.

1996 • 109 citations

Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk.

1995 • 101 citations

A new member of the Eph family of receptors that lacks protein tyrosine kinase activity.

1996 • 100 citations

The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development

1994 • 98 citations

Reciprocal Expression of the Eph Receptor Cek5 and Its Ligand(s) in the Early Retina

1997 • 97 citations

Characterization of a ligand for receptor protein-tyrosine kinase HTK expressed in immature hematopoietic cells.

1996 • 89 citations

The Expression Pattern of the Mouse Receptor Tyrosine Kinase Gene MDK1 Is Conserved through Evolution and Requires Hoxa-2 for Rhombomere-Specific Expression in Mouse Embryos

1996 • 88 citations

The Eph Kinase Ligand AL-1 Is Expressed by Rostral Muscles and Inhibits Outgrowth from Caudal Neurons

1996 • 84 citations

Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression.

1993 • 84 citations

Characterization of elk, a brain-specific receptor tyrosine kinase.

1991 • 84 citations

Purification of a ligand for the EPH-like receptor HEK using a biosensor-based affinity detection approach.

1996 • 80 citations

Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.

1995 • 68 citations

Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system.

1995 • 66 citations

Cell-Cell Adhesion Mediated by Binding of Membrane-anchored Ligand LERK-2 to the EPH-related Receptor Human Embryonal Kinase 2 Promotes Tyrosine Kinase Activity

1996 • 65 citations

cDNA cloning and characterization of a ligand for the Cek5 receptor protein-tyrosine kinase.

1994 • 62 citations

Biological and biochemical activities of a chimeric epidermal growth factor-Elk receptor tyrosine kinase.

1993 • 55 citations

Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family.

1995 • 49 citations

The Receptor Tyrosine Kinase QEK5 mRNA Is Expressed in a Gradient within the Neural Retina and the Tectum

1995 • 48 citations

Cek5, a Tyrosine Kinase of the Eph Subclass, Is Activated during Neural Retina Differentiation

1994 • 30 citations

Localization of novel receptor tyrosine kinase genes of the eph family, MDK1 and its splicing variant, in the developing mouse nervous system

1995 • 24 citations