Non-transcriptional action of oestradiol and progestin triggers DNA synthesis

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Oncogenes and signal transduction

1991 • 2,816 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

1993 • 1,836 citations

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.

1995 • 1,834 citations

Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*

1997 • 1,678 citations

Increasing complexity of Ras signaling

1998 • 1,069 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells.

1996 • 964 citations

Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

1985 • 913 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1995 • 681 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones

1997 • 649 citations

Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor

1998 • 618 citations

HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells.

1995 • 599 citations

Raf meets Ras: completing the framework of a signal transduction pathway

1994 • 591 citations

Insights from the study of animals lacking functional estrogen receptor

1994 • 587 citations

Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

1995 • 496 citations

Rapid Membrane Effects of Steroids in Neuroblastoma Cells: Effects of Estrogen on Mitogen Activated Protein Kinase Signalling Cascade and c-fos Immediate Early Gene Transcription

1997 • 478 citations

Expression and regulation of Escherichia coli lacZ gene fusions in mammalian cells.

1983 • 471 citations

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

1995 • 454 citations

Ras effectors

1996 • 445 citations

The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties.

1989 • 428 citations

MCF-7: the first hormone-responsive breast cancer cell line.

1997 • 401 citations

How receptor tyrosine kinases activate ras

1993 • 393 citations

Growth Factors in Breast Cancer

1995 • 378 citations

The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells.

1993 • 338 citations

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1994 • 331 citations

Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors.

1992 • 314 citations

Characterization of protein tyrosine kinases from human breast cancer: involvement of the c-src oncogene product.

1992 • 309 citations

Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src

1995 • 309 citations

Induction of cyclin D1 overexpression by activated ras.

1994 • 295 citations

Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression.

1993 • 295 citations

Estrogen-Dependent Cyclin E-cdk2 Activation through p21 Redistribution

1997 • 277 citations

Destabilization of Raf-1 by Geldanamycin Leads to Disruption of the Raf-1–MEK–Mitogen-Activated Protein Kinase Signalling Pathway

1996 • 274 citations

Epidermal Growth Factor Receptor Gene Expression in Estrogen Receptor-Positive and Negative Human Breast Cancer Cell Lines

1987 • 274 citations

Mitogenic Signaling of Insulin-like Growth Factor I in MCF-7 Human Breast Cancer Cells Requires Phosphatidylinositol 3-Kinase and Is Independent of Mitogen-activated Protein Kinase

1997 • 262 citations

Direct Inhibition of Cyclooxygenase-1 and -2 by the Kinase Inhibitors SB 203580 and PD 98059

1998 • 259 citations

Cell cycle targets of Ras/Raf signalling

1998 • 257 citations

Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest.

1998 • 254 citations

Variant T47D human breast cancer cells with high progesterone-receptor levels despite estrogen and antiestrogen resistance

1982 • 249 citations

DNA Synthesis Induced by Some but Not All Growth Factors Requires Src Family Protein Tyrosine Kinases

1995 • 244 citations

Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues.

1986 • 230 citations

Phosphoinositide 3-Kinase Induces Scattering and Tubulogenesis in Epithelial Cells through a Novel Pathway

1998 • 216 citations

Estrogen Regulation of c-fosMessenger Ribonucleic Acid

1988 • 205 citations

Antiestrogens inhibit the mitogenic effect of growth factors on breast cancer cells in the total absence of estrogens

1987 • 205 citations

Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice.

1994 • 203 citations

Protein folding and the regulation of signaling pathways

1994 • 184 citations

Estrogens Stimulate Cell Proliferation and Induce Secretory Proteins in a Human Breast Cancer Cell Line (T₄₇D)*

1982 • 175 citations

Estradiol activation of human colon carcinoma-derived Caco-2 cell growth.

1996 • 171 citations

Rapid Membrane Effects of Steroids in Neuroblastoma Cells: Effects of Estrogen on Mitogen Activated Protein Kinase Signalling Cascade and c-fos Immediate Early Gene Transcription

1997 • 143 citations

Src and Ras are involved in separate pathways in epithelial cell scattering

1997 • 141 citations

Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.

1993 • 139 citations

Cell cycle: Routine role for Ras

1997 • 123 citations

Immediate and transient stimulation of protein tyrosine phosphorylation by estradiol in MCF-7 cells.

1993 • 117 citations

Elevated mitogen-activated protein kinase activity in estrogen-nonresponsive human breast cancer cells.

1998 • 109 citations

Estrogen regulation of proto-oncogenes coding for nuclear proteins.

1993 • 106 citations

Growth Factor, Steroid, and Steroid Antagonist Regulation of Cyclin Gene Expression Associated With Changes in T-47D Human Breast Cancer Cell Cycle Progression

1993 • 74 citations

Inhibition of the MAP kinase cascade blocks heregulin-induced cell cycle progression in T-47D human breast cancer cells

1998 • 66 citations

Functional interaction of hybrid response elements with wild-type and mutant steroid hormone receptors.

1991 • 60 citations

Growth factors in breast cancer

1995 • 56 citations

Estrogen and oncogene mediated growth regulation of human breast cancer cells

1987 • 47 citations

The role of estradiol receptor in the proliferative activity of vanadate on MCF-7 cells.

1995 • 36 citations

Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent

1995 • 27 citations

Functional Interaction of Hybrid Response Elements with Wild-Type and Mutant Steroid Hormone Receptors

1991 • 16 citations