Progestins Induce Transcriptional Activation of Signal Transducer and Activator of Transcription 3 (Stat3) via a Jak- and Src-Dependent Mechanism in Breast Cancer Cells

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Stat3 as an Oncogene

1999 • 2,770 citations

The STATs of cancer — new molecular targets come of age

2004 • 2,232 citations

STATs in oncogenesis

2000 • 1,723 citations

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

1999 • 1,655 citations

<scp>gp</scp>130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES

1997 • 1,468 citations

A Road Map for Those Who Don't Know JAK-STAT

2002 • 1,292 citations

The role of STATs in transcriptional control and their impact on cellular function

2000 • 1,186 citations

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis

2002 • 1,160 citations

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

2003 • 1,132 citations

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

2001 • 751 citations

Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor

2003 • 697 citations

Progestin Regulation of Cellular Proliferation*

1990 • 659 citations

Stat3 Activation Is Required for Cellular Transformation by v-src

1998 • 624 citations

Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor

1998 • 618 citations

Progesterone Receptor Contains a Proline-Rich Motif that Directly Interacts with SH3 Domains and Activates c-Src Family Tyrosine Kinases

2001 • 582 citations

ErbB Receptor-induced Activation of Stat Transcription Factors Is Mediated by Src Tyrosine Kinases

1999 • 365 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.

1999 • 315 citations

Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells

2002 • 310 citations

Biphasic Regulation of Breast Cancer Cell Growth by Progesterone: Role of the Cyclin-Dependent Kinase Inhibitors, p21 and p27Kip1

1997 • 271 citations

Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells

2001 • 263 citations

Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C

2004 • 257 citations

Non-transcriptional action of oestradiol and progestin triggers DNA synthesis

1999 • 252 citations

Dominant Negative Stat3 Mutant Inhibits Interleukin-6-induced Jak-STAT Signal Transduction

1996 • 243 citations

STAT3 Acts as a Co-activator of Glucocorticoid Receptor Signaling

1997 • 236 citations

Interacting Regions in Stat3 and c-Jun That Participate in Cooperative Transcriptional Activation

1999 • 224 citations

Two Domains of the Progesterone Receptor Interact with the Estrogen Receptor and Are Required for Progesterone Activation of the c-Src/Erk Pathway in Mammalian Cells

2003 • 216 citations

Progesterone receptor transcription and non-transcription signaling mechanisms

2003 • 211 citations

Transcriptional Hyperactivity of Human Progesterone Receptors Is Coupled to Their Ligand-Dependent Down-Regulation by Mitogen-Activated Protein Kinase-Dependent Phosphorylation of Serine 294

2001 • 198 citations

Convergence of Progesterone and Epidermal Growth Factor Signaling in Breast Cancer

1998 • 197 citations

Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells.

1997 • 189 citations

Convergence of Progesterone with Growth Factor and Cytokine Signaling in Breast Cancer

1998 • 182 citations

Selective inhibition of STAT3 induces apoptosis and G1 cell cycle arrest in ALK-positive anaplastic large cell lymphoma

2004 • 169 citations

Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity

2000 • 168 citations

Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest.

2001 • 127 citations

G-Quartet Oligonucleotides

2004 • 126 citations

Interactions in the transcriptional regulation exerted by Stat5 and by members of the steroid hormone receptor family

1999 • 120 citations

Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells

2001 • 120 citations

Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells

2004 • 115 citations

Autocrine-mediated Activation of STAT3 Correlates with Cell Proliferation in Breast Carcinoma Lines

2002 • 104 citations

ErbB-2 Activates Stat3α in a Src- and JAK2-dependent Manner

2002 • 101 citations

Heregulin Induces Transcriptional Activation of the Progesterone Receptor by a Mechanism That Requires Functional ErbB-2 and Mitogen-Activated Protein Kinase Activation in Breast Cancer Cells

2003 • 84 citations

Stat3 enhances transactivation of steroid hormone receptors.

2003 • 72 citations

Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity

2004 • 65 citations

Progestin Effects on Long-Term Growth, Death, and Bcl-xL in Breast Cancer Cells

2000 • 64 citations

Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas

1999 • 56 citations

Actions of a progestogen on human breast cancer cells: Mechanisms of growth stimulation and inhibition

1987 • 55 citations

Platelet-derived growth factor (PDGF)-induced activation of signal transducer and activator of transcription (Stat) 5 is mediated by PDGF beta-receptor and is not dependent on c-src, fyn, jak1 or jak2 kinases.

2000 • 52 citations

Role of Signal Transducers and Activators of Transcription 1 and -3 in Inducible Regulation of the Human Angiotensinogen Gene by Interleukin-6

2001 • 49 citations

Thrombopoietin induces the generation of distinct Stat1, Stat3, Stat5a and Stat5b homo- and heterodimeric complexes with different kinetics in human platelets

2000 • 44 citations

Effects of progestins on growth of experimental breast cancer in culture: interaction with estradiol and prolactin and involvement of the polyamine pathway.

1987 • 44 citations

A reappraisal of progesterone action in the mammary gland.

2000 • 43 citations

Effect of medroxyprogesterone acetate (MPA) and serum factors on cell proliferation in primary cultures of an MPA-induced mammary adenocarcinoma

1995 • 42 citations

Progesterone Induces Cellular Differentiation in MDA-MB-231 Breast Cancer Cells Transfected with Progesterone Receptor Complementary DNA

2003 • 38 citations

Heregulin inhibits proliferation via ERKs and phosphatidyl‐inositol 3‐kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells

2002 • 37 citations

Platelet-derived growth factor (PDGF)-induced activation of signal transducer and activator of transcription (Stat) 5 is mediated by PDGF β-receptor and is not dependent on c-Src, Fyn, Jak1 or Jak2 kinases

2000 • 35 citations

Signal Transducer and Activator of Transcription 3 Is Expressed in the Decidualized Mesometrium of Pregnancy and Associates with the Progesterone Receptor Through Protein-Protein Interactions1

2002 • 32 citations

Effect of Progesterone on Cell Proliferation in the MXT Mouse Hormone-Sensitive Mammary Neoplasm<xref ref-type="fn" rid="FN1">2</xref>

1986 • 27 citations

ONCOSTATIN M ACTIVATES STAT DNA BINDING AND TRANSCRIPTIONAL ACTIVITY IN PRIMARY HUMAN FETAL ASTROCYTES: LOW- AND HIGH-PASSAGE CELLS HAVE DISTINCT PATTERNS OF STAT ACTIVATION

2000 • 19 citations