Expression of Intestine-Specific Antigen Reveals Novel Pathways of CD8 T Cell Tolerance Induction

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Inflammatory Bowel Disease

1991 • 1,264 citations

Fundamental Immunology

1999 • 1,011 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

2000 • 908 citations

Negative selection of lymphocytes

1994 • 810 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule

1990 • 689 citations

Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin

1995 • 672 citations

Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes

1988 • 663 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

Heterologous introns can enhance expression of transgenes in mice.

1991 • 489 citations

Epithelial stem cells in vivo

1988 • 446 citations

Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice

1997 • 422 citations

CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells

1998 • 300 citations

The roles of perforin‐ and Fas‐dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

1995 • 286 citations

The Ligands and Receptors of the Lymphotoxin System

1995 • 262 citations

Interferon-γ Is Essential for Destruction of β Cells and Development of Insulin-dependent Diabetes Mellitus

1997 • 220 citations

A Natural Immunological Adjuvant Enhances T Cell Clonal Expansion through a CD28-dependent, Interleukin (IL)-2–independent Mechanism

1998 • 220 citations

Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization.

1989 • 220 citations

Cross-tolerance: A Pathway for Inducing Tolerance to Peripheral Tissue Antigens

1998 • 216 citations

Use of adoptive transfer of T‐cell antigen‐receptor‐transgenic T cells for the study of T‐cell activation in vivo

1997 • 205 citations

Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-γ, TNF) in the induction of epithelial cell death and renewal

1998 • 202 citations

Split Anergy in a CD8 ⁺ T Cell: Receptor-dependent Cytolysis in the Absence of Interleukin-2 Production

1991 • 199 citations

Chronic intestinal inflammation: An unexpected outcome in cytokine or T cell receptor mutant mice

1993 • 193 citations

Endogenous generation and presentation of the ovalbumin peptide/Kb complex to T cells.

1993 • 185 citations

Transgenic mice containing intestinal fatty acid-binding protein-human growth hormone fusion genes exhibit correct regional and cell-specific expression of the reporter gene in their small intestine.

1988 • 174 citations

Antigen-driven induction of CD11c on intestinal intraepithelial lymphocytes and CD8+ T cells in vivo.

1995 • 171 citations

Viral and Bacterial Infections Interfere with Peripheral Tolerance Induction and Activate CD8+ T Cells to Cause Immunopathology

1998 • 161 citations

The type I interleukin‐1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF‐transgenic mice

1995 • 159 citations

Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis

1998 • 154 citations

Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions.

1996 • 143 citations

Autoimmune Intestinal Pathology Induced by hsp60-Specific CD8 T Cells

1999 • 136 citations

Modifications of CD8+ T Cell Function during In Vivo Memory or Tolerance Induction

1998 • 134 citations

Generation of mucosal cytotoxic T cells against soluble protein by tissue-specific environmental and costimulatory signals

1998 • 122 citations

Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity.

1996 • 119 citations

TNF-induced enterocyte apoptosis in mice is mediated by the TNF receptor 1 and does not require p53

1998 • 106 citations

Activation and migration of CD8 T cells in the intestinal mucosa.

1997 • 102 citations

The Mouse Intestinal Fatty Acid Binding Protein Gene: Nucleotide Sequence, Pattern of Developmental and Regional Expression, and Proposed Structure of Its Protein Product

1992 • 86 citations

Human intestinal epithelial cell-induced CD8+ T cell activation is mediated through CD8 and the activation of CD8-associated p56lck.

1995 • 73 citations

Age-dependent intestinal lymphoproliferative disorder due to stem cell factor receptor deficiency: parameters in small and large intestine.

1997 • 69 citations

T cells in inductive and effector compartments of the intestinal mucosal immune system of nonhuman primates differ in lymphokine mRNA expression, lymphokine utilization, and regulatory function.

1990 • 61 citations

Medical Therapy of Inflammatory Bowel Disease

1998 • 52 citations

Multiple sites of post‐activation CD8⁺ T cell disposal

1997 • 44 citations