Interferon-γ Is Essential for Destruction of β Cells and Development of Insulin-dependent Diabetes Mellitus

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

1993 • 2,410 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 • 1,558 citations

Intracellular Inactivation of the Hepatitis B Virus by Cytotoxic T Lymphocytes

1996 • 1,085 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 • 1,073 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Insulin-Dependent Diabetes Mellitus as an Autoimmune Disease

1994 • 818 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Interferon‐γ confers resistance to experimental allergic encephalomyelitis

1996 • 478 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

Role of cytokines in determining T-lymphocyte function

1994 • 396 citations

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

1991 • 381 citations

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

1996 • 349 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Differential Regulation of Murine T Lymphocyte Subsets

1993 • 343 citations

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1994 • 309 citations

A Central Role of Perforin in Cytolysis?

1991 • 288 citations

Response to influenza infection in mice with a targeted disruption in the interferon gamma gene.

1993 • 247 citations

Genetic Absence of γ-Interferon Delays but Does Not Prevent Diabetes in NOD Mice

1996 • 244 citations

Genomic and Biological Variation among Commonly Used Lymphocytic Choriomeningitis Virus Strains

1983 • 241 citations

Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver.

1996 • 199 citations

Coexpression of B7-1 and viral (“self”) transgenes in pancreatic β cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes

1995 • 177 citations

THE EPIDEMIOLOGY OF INSULIN DEPENDENT DIABETES, WITH PARTICULAR REFERENCE TO THE RELATIONSHIP OF VIRUS INFECTION TO ITS ETIOLOGY

1980 • 162 citations

Analyses of the cytotoxic T lymphocyte responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus

1988 • 155 citations

Altered Cytokine Activity in Adjuvant Inhibition of Autoimmune Diabetes

1993 • 151 citations

An Essential Role for Type 1 Interferon-γ in Terminating Persistent Viral Infection

1995 • 145 citations

Induction of diabetes is influenced by the infectious virus and local expression of MHC class I and tumor necrosis factor-alpha.

1993 • 133 citations

Molecular definition of a major cytotoxic T-lymphocyte epitope in the glycoprotein of lymphocytic choriomeningitis virus

1988 • 125 citations

Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction.

1994 • 121 citations

Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity.

1996 • 119 citations

Molecular characterization of the genomic S RNA segment from lymphocytic choriomeningitis virus

1987 • 108 citations

Virus Persists in β Cells of Islets of Langerhans and Is Associated with Chemical Manifestations of Diabetes

1984 • 107 citations

Type 2 cytokines and negative immune regulation in human infections

1993 • 105 citations

Analysis of the Spontaneous T Cell Response to Insulin in NOD Mice

1994 • 101 citations

Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus.

1994 • 89 citations

Analysis of IL-2, IL-4, and IFN-gamma-producing cells in situ during immune responses to protein antigens.

1993 • 77 citations

Destruction of pancreatic islet cells by cytotoxic T lymphocytes in nonobese diabetic mice.

1989 • 73 citations

Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin‐2 in islet β cells

1992 • 71 citations

Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response.

1995 • 53 citations

Sensitization to self (virus) antigen by in situ expression of murine interferon-gamma.

1995 • 52 citations

Molecular pathology of type 1 diabetes.

1990 • 38 citations

Morphological Analysis of Selective Destruction of Pancreatic β-cells by Cytotoxic T Lymphocytes in NOD Mice

1991 • 35 citations

The 64-kDa Beta Cell Membrane Autoantigen and Other Target Molecules of Humoral Autoimmunity in Insulin-Dependent Diabetes Mellitus

1990 • 31 citations

Virus and cytotoxic T lymphocytes: crucial role of viral peptide secondary structure in major histocompatibility complex class I interactions

1993 • 24 citations

Immune Pathogenesis of Diabetes in the Nonobese Diabetic Mouse: An Overview

1990 • 12 citations

Novel LCMV-specific H-2k restricted CTL clones recognize internal viral gene products and cause CNS disease

1992 • 9 citations