Cross-tolerance: A Pathway for Inducing Tolerance to Peripheral Tissue Antigens

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Introduction of soluble protein into the class I pathway of antigen processing and presentation

1988 • 1,105 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens.

1992 • 435 citations

A new foreign policy: MHC class I molecules monitor the outside world

1996 • 422 citations

Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages

1995 • 416 citations

Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.

1990 • 414 citations

Experimental allergic encephalomyelitis

1969 • 406 citations

Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.

1996 • 405 citations

Constitutive macropinocytosis allows TAP‐dependent major histocompatibility compex class I presentation of exogenous soluble antigen by bone marrow‐derived dendritic cells

1997 • 351 citations

CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity

1997 • 320 citations

Type II Collagen Autoimmunity in Animals and Provocations Leading to Arthritis

1990 • 304 citations

CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells

1998 • 300 citations

Homing of naive, memory and effector lymphocytes

1993 • 295 citations

THE ENCEPHALOMYELITIC ACTIVITY OF MYELIN ISOLATED BY ULTRACENTRIFUGATION

1962 • 295 citations

High Levels of a Major Histocompatibility Complex II–Self Peptide Complex on Dendritic Cells from the T Cell Areas of Lymph Nodes

1997 • 292 citations

A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production.

1996 • 238 citations

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance.

1995 • 225 citations

Peripheral tolerance to an islet cell‐specific hemagglutinin transgene affects both CD4⁺ and CD8⁺ T cells

1992 • 217 citations

RETRACTED: The Fas/Fas Ligand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign Antigens

1998 • 216 citations

Class discrimination in the world of immunology

1987 • 214 citations

A fail-safe mechanism for maintaining self-tolerance.

1992 • 213 citations

Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules.

1993 • 206 citations

Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

1996 • 196 citations

The Yin and Yang of T Cell Costimulation

1995 • 180 citations

The Peripheral Deletion of Autoreactive CD8+ T Cells Induced by Cross-presentation of Self-antigens Involves Signaling through CD95 (Fas, Apo-1)

1998 • 173 citations

Conditions That Induce Tolerance in Mature CD4+ T Cells

1997 • 149 citations

Three‐cell‐type clusters of T cells with antigen‐presenting cells best explain the epitope linkage and noncognate requirements of the in vivo cytolytic response

1987 • 141 citations

Genetics and Immunology of Sex-Linked Antigens

1972 • 130 citations

Limited capacity for tolerization of CD4+ T cells specific for a pancreatic β cell neo-antigen

1995 • 121 citations

Exogenous antigens gain access to the major histocompatibility complex class I processing pathway in B cells by receptor-mediated uptake.

1996 • 111 citations

Minor but not major histocompatibility antigens of thymus epithelium tolerize precursors of cytolytic T cells

1986 • 109 citations

In vivo activation of naive T cells by antigen-presenting B cells.

1994 • 95 citations

Antigen‐presenting cells in adoptively transferred and spontaneous autoimmune diabetes

1993 • 91 citations

Tolerogenicity of resting and activated B cells.

1994 • 83 citations

Peripheral tolerance of CD4 T cells following local activation in adolescent mice

1996 • 82 citations

The effect of allogeneic presensitization on H-Y graft survival and in vitro cell-mediated responses to H-y antigen.

1976 • 82 citations

Parameters of tolerance induction by antigen targeted to B lymphocytes.

1993 • 73 citations

Interleukin 3 enhances cytotoxic T lymphocyte development and class I major histocompatibility complex "re-presentation" of exogenous antigen by tumor-infiltrating antigen-presenting cells.

1996 • 67 citations

Autoimmunity caused by ignorant CD8+ T cells is transient and depends on avidity.

1995 • 60 citations

Induction of B cell and T cell tolerance in vivo by anti-CD23 mAb.

1994 • 35 citations

A new method of typing inbred strains of mice for histocompatibility antigens.

1957 • 14 citations