Role of TNF-α Receptors in Mice Intoxicated with the Parkinsonian Toxin MPTP

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Signal transduction by tumor necrosis factor and its relatives

2001 • 1,623 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases

1995 • 1,290 citations

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1996 • 947 citations

Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 • 933 citations

Tumor necrosis factor-α (TNF-α) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients

1994 • 923 citations

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-κB control

1997 • 875 citations

TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR

1988 • 814 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

Interleukin-1β, interleukin-6, epidermal growth factor and transforming growth factor-α are elevated in the brain from parkinsonian patients

1994 • 788 citations

Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.

1991 • 735 citations

Cytokines in inflammatory brain lesions: helpful and harmful

1996 • 727 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Nuclear translocation of NF-κB is increased in dopaminergic neurons of patients with Parkinson disease

1997 • 676 citations

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

1994 • 672 citations

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

1995 • 632 citations

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1994 • 607 citations

Microglia in degenerative neurological disease

1993 • 594 citations

Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease

1994 • 576 citations

Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1997 • 572 citations

TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination

1998 • 553 citations

Tumor Necrosis Factor Induces Bcl-2 and Bcl-x Expression through NFκB Activation in Primary Hippocampal Neurons

1999 • 552 citations

The substantia nigra of the human brain

1999 • 551 citations

Interleukin (IL)-1β, IL-2, IL-4, IL-6 and transforming growth factor-α levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease

1996 • 518 citations

The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.

1989 • 511 citations

The Structure of Tumor Necrosis Factor-α at 2.6 Å Resolution

1989 • 441 citations

Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury

1999 • 413 citations

FcepsilonRII/CD23 is expressed in Parkinson's disease and induces, in vitro, production of nitric oxide and tumor necrosis factor-alpha in glial cells.

1999 • 401 citations

The Inflammatory Reaction Following 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Intoxication in Mouse

1999 • 372 citations

TNF-α Pretreatment Induces Protective Effects against Focal Cerebral Ischemia in Mice

1997 • 346 citations

FcεRII/CD23 Is Expressed in Parkinson’s Disease and Induces,In Vitro,Production of Nitric Oxide and Tumor Necrosis Factor-α in Glial Cells

1999 • 335 citations

Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-α inhibitor and an effective neuroprotectant

1997 • 332 citations

Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures

1991 • 304 citations

Tumor Necrosis Factor Alpha-Induced Apoptosis in Human Neuronal Cells: Protection by the Antioxidant N-Acetylcysteine and the Genes bcl-2 and crmA

1995 • 300 citations

Stimulation of human T-cell proliferation by specific activation of the 75-kDa tumor necrosis factor receptor.

1993 • 297 citations

Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase

1994 • 294 citations

Inhibition of Tumor Necrosis Factor Alpha (TNFα) Activity in Rat Brain is Associated with Cerebroprotection after Closed Head Injury

1996 • 284 citations

Exacerbation of Damage and Altered NF-κB Activation in Mice Lacking Tumor Necrosis Factor Receptors after Traumatic Brain Injury

1999 • 271 citations

Tumor Necrosis Factor

1988 • 261 citations

Tumor Necrosis Factor-Alpha Potentiates Glutamate Neurotoxicity in Human Fetal Brain Cell Cultures

1994 • 243 citations

Cellular signaling roles of TGFβ, TNFα and βAPP in brain injury responses and Alzheimer's disease

1997 • 243 citations

Chapter 36: Astrocytes and Parkinson's disease

1992 • 226 citations

Tumor Necrosis Factor α Is Toxic to Embryonic Mesencephalic Dopamine Neurons

2001 • 219 citations

Deficient liver regeneration after carbon tetrachloride injury in mice lacking type 1 but not type 2 tumor necrosis factor receptor.

1998 • 211 citations

Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis

2001 • 182 citations

Cytokines in neurodegeneration and repair

1995 • 165 citations

Transforming growth factor-β1 levels are elevated in the striatum and in ventricular cerebrospinal fluid in Parkinson's disease

1995 • 162 citations

Cytokine regulation of embryonic rat dopamine and serotonin neuronal survival in vitro

1997 • 157 citations

Cooperation of Both TNF Receptors in Inducing Apoptosis: Involvement of the TNF Receptor-Associated Factor Binding Domain of the TNF Receptor 75

1998 • 150 citations

Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1

1998 • 149 citations

Contributions of angiotensin II and tumor necrosis factor-α to the development of renal fibrosis

2001 • 146 citations

Brain injury and tumor necrosis factors induce calbindin D‐28K in astrocytes: Evidence for a cytoprotective response

1995 • 142 citations

Differential strain susceptibility following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration acts in an autosomal dominant fashion: quantitative analysis in seven strains of Mus musculus

1999 • 140 citations

In vitro evidence for a dual role of tumor necrosis factor‐α in human immunodeficiency virus type 1 encephalopathy

1995 • 138 citations

5′ Flanking DNA Sequences Direct Cell‐Specific Expression of Rat Tyrosine Hydroxylase

1989 • 136 citations

AIDS Dementia Is Associated with Massive, Activated HIV-1 Infection and Concomitant Expression of Several Cytokines

1996 • 128 citations

Regulation of GDNF expression in cultured astrocytes by inflammatory stimuli

1997 • 122 citations

Drug-free evaluation of rat models of parkinsonism and nigral grafts using a new automated rotarod test

1997 • 111 citations

MHC class II positive microglia and lymphocytic infiltration are present in the substantia nigra and striatum in mouse model of Parkinson's disease.

1999 • 111 citations

Brain β2-microglobulin levels are elevated in the striatum in Parkinson's diseaselevels are elevated in the striatum in Parkinson's disease

1995 • 102 citations

Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD

1999 • 101 citations

Multifunctional Regulation of the Biological Effects of TNF-α by the Soluble Type I and Type II TNF Receptors

1995 • 99 citations

Glial expression of cytokines in the brains of cerebrovascular disease patients

1996 • 86 citations

Simultaneous measurement of monoamines, metabolites and amino acids in brain tissue and microdialysis perfusates

1993 • 80 citations

Increase in level of tumor necrosis factor (TNF)-α in 6-hydroxydopamine-lesioned striatum in rats without influence of systemic l-DOPA on the TNF-α induction

1999 • 75 citations

Attenuation and augmentation of ischaemia‐related neuronal death by tumour necrosis factor‐α in vitro

2000 • 68 citations

Effects of repeated systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mice on interleukin-1β and nerve growth factor in the striatum

1998 • 68 citations

Differential responses of fibroblasts from wild-type and TNF-R55-deficient mice to mouse and human TNF-alpha activation.

1994 • 67 citations

Differential Oligodendroglial Expression of the Tumor Necrosis Factor Receptors In Vivo and In Vitro

1995 • 62 citations

Tumor Necrosis Factor Receptors (Tnfr) in Mouse Fibroblasts Deficient in Tnfr1 or Tnfr2 are Signaling Competent and Activate the Mitogen-activated Protein Kinase Pathway with Differential Kinetics

1996 • 62 citations

Both TNF receptors are required for direct TNF‐mediated cytotoxicity in microvascular endothelial cells

1998 • 58 citations

TNF-α expressed in the brain of transgenic mice lowers central tyroxine hydroxylase immunoreactivity and alters grooming behavior

1997 • 57 citations

Stimulation of different phospholipase A₂isoforms by TNF-α and IL-1β in adult rat ventricular myocytes

1998 • 55 citations

Glial cell participation in the degeneration of dopaminergic neurons in Parkinson's disease.

1999 • 54 citations

Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons

1999 • 50 citations

Both TNF receptors are required for direct TNF-mediated cytotoxicity in microvascular endothelial cells

1998 • 49 citations

Screening of interleukins for survival-promoting effects on cultured mesencephalic dopaminergic neurons from embryonic rat brain

1995 • 33 citations

The acute effect on levels of catecholamines and metabolites in brain, of a single dose of MPTP in 8 strains of mice

1989 • 29 citations

Inhibition of tumor necrosis factor and interferon triggered responses by DNA viruses

1998 • 27 citations

Effects of endotoxin and tumor necrosis factor α on regional brain neurotransmitters in mice

1999 • 17 citations

Selective acid vulnerability of dopaminergic neurons and its recovery by brain-derived neurotrophic factor

1995 • 16 citations