Chapter 36: Astrocytes and Parkinson's disease

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease

1988 • 1,881 citations

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1985 • 1,236 citations

Greenfield's Neuropathology

1985 • 1,149 citations

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

1984 • 913 citations

Effect of Deprenyl on the Progression of Disability in Early Parkinson's Disease

1989 • 913 citations

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

1984 • 772 citations

The Effect of Deprenyl (Selegiline) on the Natural History of Parkinson's Disease

1989 • 621 citations

Pargyline Prevents MPTP-Induced Parkinsonism in Primates

1984 • 575 citations

1-Methyl-4-phenylpyridinium ion (MPP+): Identification of a metabolite of MPTP, a toxin selective to the substantia nigra

1984 • 423 citations

Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

1989 • 414 citations

Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria.

1986 • 404 citations

Parkinson's disease and movement disorders

1989 • 353 citations

Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys

1986 • 347 citations

Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys

1984 • 323 citations

Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP

1984 • 313 citations

MPTP Toxicity: Implications for Research in Parkinson's Disease

1988 • 287 citations

CONCENTRIC HYALIN INTRANEURONAL INCLUSIONS OF LEWY TYPE IN THE BRAINS OF ELDERLY PERSONS (50 INCIDENTAL CASES): RELATIONSHIP TO PARKINSONISM

1969 • 217 citations

Astrocytes convert the parkinsonism inducing neurotoxin, MPTP, to its active metabolite, MPP+

1987 • 200 citations

A brainstem atlas of catecholaminergic neurons in man, using melanin as a natural marker

1981 • 174 citations

General pathology of neurons and neuroglia

1992 • 134 citations

THE HISTOCHEMICAL RELATIONSHIP OF NEUROMELANIN AND LIPOFUSCIN

1969 • 124 citations

Dopamine uptake blockers protect against the dopamine depleting effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatum

1985 • 110 citations

Light and electron microscopic studies of pigment in human and rhesus monkey substantia nigra and locus coeruleus

1966 • 99 citations

THE STRIATONIGRAL DEGENERATIONS

1975 • 95 citations

Astrocytes as a primary locus for the conversion MPTP into MPP+

1989 • 85 citations

Effect of Aging on Tyrosine Hydroxylase Protein Content and the Relative Number of Dopamine Nerve Terminals in Human Caudate

1991 • 81 citations

Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP

1985 • 70 citations

MPP+ (1-methyl-4-phenylpyridine) is a neurotoxin to dopamine-, norepinephrine- and serotonin-containing neurons

1987 • 51 citations

Biotransformation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes.

1991 • 50 citations

The anatomy and pigmentation of the human substantia nigra in relation to selective neuronal vulnerability.

1990 • 41 citations

The catecholamine uptake blocker nomifensine protects against MPTP-induced parkinsonism in monkeys

1986 • 37 citations

Depigmentation in the nerve cells of the substantia nigra and locus ceruleus in Parkinsonism.

1974 • 35 citations

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