Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells

The p53 pathway: positive and negative feedback loops

2005 • 1,899 citations

Changes in thymic function with age and during the treatment of HIV infection

1998 • 1,887 citations

Cellular signaling by fibroblast growth factor receptors

2005 • 1,873 citations

Bone Morphogenetic Proteins

2004 • 1,795 citations

Fibroblast growth factors, their receptors and signaling.

2000 • 1,303 citations

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

1999 • 1,248 citations

Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy

1995 • 1,066 citations

NF-κB as a Therapeutic Target in Multiple Myeloma

2002 • 906 citations

A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway

1997 • 861 citations

Assessment of thymic output in adults after haematopoietic stemcell transplantation and prediction of T-cell reconstitution

2000 • 597 citations

Keratinocyte growth factor is required for hair development but not for wound healing.

1996 • 541 citations

The Role of the Thymus in Immune Reconstitution in Aging, Bone Marrow Transplantation, and HIV-1 Infection

2000 • 506 citations

Interleukin-7: from bench to clinic

2002 • 496 citations

Activation of Thymic Regeneration in Mice and Humans following Androgen Blockade

2005 • 465 citations

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

2002 • 449 citations

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells

2006 • 443 citations

Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation

2001 • 436 citations

Mapping Precursor Movement through the Postnatal Thymus Reveals Specific Microenvironments Supporting Defined Stages of Early Lymphoid Development

2001 • 394 citations

MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus

1993 • 359 citations

The generation and fate of thymocytes.

1990 • 309 citations

Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

1998 • 292 citations

Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells

2002 • 290 citations

The Thymus Is a Common Target Organ in Infectious Diseases

2006 • 277 citations

Identification and Characterization of Thymic Epithelial Progenitor Cells

2002 • 269 citations

Recovery of immune reactivity after T-cell–depleted bone marrow transplantation depends on thymic activity

2000 • 258 citations

Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice

2002 • 254 citations

Development of the Thymus Requires Signaling Through the Fibroblast Growth Factor Receptor R2-IIIb

2001 • 241 citations

Pathways of T‐cell regeneration in mice and humans: implications for bone marrow transplantation and immmunotherapy

1997 • 235 citations

Keratinocyte Growth Factor⧸Fibroblast Growth Factor 7, a Homeostatic Factor with Therapeutic Potential for Epithelial Protection and Repair

2004 • 233 citations

Chemokines define distinct microenvironments in the developing thymus

2000 • 218 citations

Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration

2005 • 208 citations

Analysis of thymic stromal cell populations using flow cytometry

2002 • 206 citations

Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease

2002 • 195 citations

Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization

2006 • 194 citations

Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

2001 • 193 citations

Regulation of Thymus Size by Competition for Stromal Niches among Early T Cell Progenitors

2004 • 192 citations

BMP Signaling Is Required for Normal Thymus Development

2005 • 171 citations

T Cell Homeostasis

2001 • 163 citations

Kinetics of Steady-state Differentiation and Mapping of Intrathymic-signaling Environments by Stem Cell Transplantation in Nonirradiated Mice

2003 • 160 citations

A multistep adhesion cascade for lymphoid progenitor cell homing to the thymus

2006 • 155 citations

Reconstitution of T-cell receptor repertoire diversity following T-cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimerism

2000 • 154 citations

Differential Requirement for Mesenchyme in the Proliferation and Maturation of Thymic Epithelial Progenitors

2003 • 153 citations

Regulation of thymic epithelium by keratinocyte growth factor

2002 • 150 citations

From stem cell to T cell: one route or many?

2006 • 144 citations

Phase 1/2 randomized, placebo-control trial of palifermin to prevent graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT)

2006 • 142 citations

Strategies to enhance T-cell reconstitution in immunocompromised patients

2004 • 142 citations

The role of CCL21 in recruitment of T-precursor cells to fetal thymi

2004 • 137 citations

Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance.

1990 • 135 citations

Loss of normal thymic repertoire selection and persistence of autoreactive T cells in graft vs host disease.

1994 • 128 citations

BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis

2003 • 124 citations

Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules

2006 • 119 citations

Wnt-1 and Wnt-4 regulate thymic cellularity

2002 • 113 citations

IL-7 Gene Therapy in Aging Restores Early Thymopoiesis without Reversing Involution

2004 • 106 citations

The phenotypic heterogeneity of mouse thymic stromal cells.

1990 • 104 citations

Keratinocyte growth factor induces Akt kinase activity and inhibits Fas-mediated apoptosis in A549 lung epithelial cells

2004 • 93 citations

GRAFT-VERSUS-HOST-DISEASE-ASSOCIATED THYMIC DAMAGE RESULTS IN THE APPEARANCE OF T CELL CLONES WITH ANTI-HOST REACTIVITY1

2000 • 85 citations

Mammalian Twisted Gastrulation Is Essential for Skeleto-Lymphogenesis

2003 • 84 citations

T-Cell Immune Reconstitution in Pediatric Leukemia Patients After Allogeneic Bone Marrow Transplantation With T-Cell–Depleted or Unmanipulated Grafts: Evaluation of Overall and Antigen-Specific T-Cell Repertoires

1999 • 83 citations

The Thymus During HIV Disease: Role in Pathogenesis and in Immune Recovery

2004 • 79 citations

Phenotypically diverse mouse thymic stromal cell lines which induce proliferation and differentiation of hematopoietic cells

1993 • 74 citations

Immune reconstitution following hematopoietic progenitor cell transplantation: challenges for the future

2005 • 72 citations

Thymic epithelial antibodies: immunohistological analysis and introduction of nomenclature.

1989 • 66 citations

Thymic atrophy in murine acute graft-versus-host disease is effected by impaired cell cycle progression of host pro-T and pre-T cells

2000 • 64 citations

Keratinocyte Growth Factor Stimulates Alveolar Type II Cell Proliferation through the Extracellular Signal–Regulated Kinase and Phosphatidylinositol 3-OH Kinase Pathways

2004 • 61 citations

Thymic selection and thymic major histocompatibility complex class II expression are abnormal in mice undergoing graft-versus-host reactions.

1993 • 58 citations

REQUIREMENT OF RESIDUAL THYMUS TO RESTORE NORMAL T-CELL SUBSETS AFTER HUMAN ALLOGENEIC BONE MARROW TRANSPLANTATION1

2000 • 57 citations

Total lymphoid irradiation leads to transient depletion of the mouse thymic medulla and persistent abnormalities among medullary stromal cells.

1988 • 54 citations

The quantitative assessment of MHC II on thymic epithelium: implications in cortical thymocyte development

2006 • 51 citations

IL-7 activates alpha4beta1 integrin in murine thymocytes.

1997 • 50 citations

Ras inhibitors and radiation therapy

2001 • 47 citations

Reconstitution of thymic function after stem cell transplantation in humans

2002 • 47 citations

Generation of primary tumor-specific CTL in vitro to immunogenic and poorly immunogenic mouse tumors.

1996 • 46 citations

Scheduled kinetics of cell proliferation and phenotypic changes during immature thymocyte generation

2001 • 44 citations

Lineage choices in the developing thymus: choosing the T and NKT pathways

2004 • 37 citations

The influence of dexamethasone treatment on the lymphoid and stromal composition of the mouse thymus: A flowcytometric and immunohistological analysis

1986 • 37 citations

Reconstitution of T-cell receptor repertoire diversity following T-cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimerism

2000 • 30 citations

On the Relevance of TCR Rearrangement Circles as Molecular Markers for Thymic Output during Experimental Graft-versus-Host Disease

2004 • 24 citations

Keratinocyte growth factor (KGF) is required for post-natal thymic regeneration

2005 • 18 citations

Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

2001 • 16 citations

Wnt-1 and Wnt-4 regulate thymic cellularity

2002 • 13 citations