Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance.

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Allogeneic Bone‐Marrow Transplantation

1983 • 614 citations

Lethal graft-versus-host disease after bone marrow transplantation across minor histocompatibility barriers in mice. Prevention by removing mature T cells from marrow.

1978 • 524 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases

1984 • 354 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

Allogenic bone marrow transplantation: current status and future directions

1983 • 309 citations

Deletion of self-reactive T cells before entry into the thymus medulla

1988 • 171 citations

Humoral and cell-mediated immune responses in fully allogeneic bone marrow chimera in mice

1980 • 136 citations

Distribution of H-2 microenvironments in the mouse thymus. Immunoelectron microscopic identification of I-A and H-2K bearing cells.

1980 • 127 citations

Allosuppressor and allohelper T cells in acute and chronic graft-vs.-host disease. II. F1 recipients carrying mutations at H-2K and/or I-A.

1983 • 118 citations

Graft‐versus‐Host Disease

1985 • 117 citations

Role of T cell subsets in lethal graft-versus-host disease (GVHD) directed to class I versus class II H-2 differences. I. L3T4+ cells can either augment or retard GVHD elicited by Lyt-2+ cells in class I different hosts.

1988 • 104 citations

Two monoclonal rat antibodies with specificity for the beta-chain variable region V beta 6 of the murine T-cell receptor.

1988 • 100 citations

Functions of Purified L3T4⁺ and Lyt‐2⁺ Cells in vitro and in vivo

1986 • 92 citations

Characterization of alloimmunization-induced T lymphocytes reactive against AKR leukemia in vitro and correlation with graft-vs-leukemia activity in vivo.

1983 • 83 citations

Clonal deletion of self-reactive T cells in irradiation bone marrow chimeras and neonatally tolerant mice. Evidence for intercellular transfer of Mlsa.

1989 • 76 citations

Effects of T cell depletion in radiation bone marrow chimeras. I. Evidence for a donor cell population which increases allogeneic chimerism but which lacks the potential to produce GVHD.

1988 • 67 citations

Further evidence against random polyclonal antibody formation in mice with lupus-like graft-vs-host disease.

1984 • 48 citations

Immune function in fully allogeneic mouse bone marrow chimeras

1981 • 42 citations

Bone marrow transplantation—An expanding approach to treatment of many diseases

1983 • 39 citations

GVHR elicited by products of class I or class II loci of the MHC: analysis of the response of mouse T lymphocytes to products of class I and class II loci of the MHC in correlation with GVHR-induced mortality, medullary aplasia, and enteropathy.

1985 • 34 citations

Sequential changes of thymocyte surface antigens with presence or absence of graft-vs-host reaction following allogeneic bone marrow transplantation

1982 • 25 citations

A study on proliferative responses to host Ia antigens in allogeneic bone marrow chimera in mice: sequential analysis of the reactivity and characterization of the cells involved in the responses.

1987 • 20 citations

Bone marrow cells from allogeneic bone marrow chimeras inhibit the generation of cytotoxic lymphocyte responses against both donor and recipient cells.

1988 • 16 citations

Cause of Homologous Disease

1967 • 12 citations

Activation of T cells by H-2 factors in the graft-vs-host reaction.

1973 • 12 citations

Donor and Recipient Specific Tolerance in Cells from Semi-Allogeneic, H-2 Subregion Compatible or Fully Allogeneic Bone Marrow Chimeras Attributable to Clonal

1989 • 11 citations

A Study on Graft‐versus‐Host Reaction (GVHR) by Simonsen's Splenomegaly Assay Cells and Antigen Systems Involved in Induction of GVHR

1989 • 10 citations

Deletion of Mls‐reactive T cells in H‐2‐compatible but Mls‐incompatible bone marrow chimeras

1989 • 9 citations