Pathways of T‐cell regeneration in mice and humans: implications for bone marrow transplantation and immmunotherapy

IMMUNOLOGICAL FUNCTION OF THE THYMUS

1961 • 1,359 citations

Infusions of Donor Leukocytes to Treat Epstein-Barr Virus-Associated Lymphoproliferative Disorders after Allogeneic Bone Marrow Transplantation

1994 • 1,078 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy

1995 • 1,066 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Peripheral Selection of the T Cell Repertoire

1991 • 666 citations

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1980 • 551 citations

Idiotypic Networks and Other Preconceived Ideas

1984 • 543 citations

In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cells

1977 • 534 citations

CD8 naive T cell counts decrease progressively in HIV-infected adults.

1995 • 495 citations

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis

1996 • 452 citations

Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing.

1996 • 418 citations

CD28- T lymphocytes. Antigenic and functional properties.

1993 • 403 citations

Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping: correlation with immune status

1995 • 400 citations

Distinctions Between CD8+ and CD4+ T-Cell Regenerative Pathways Result in Prolonged T-Cell Subset Imbalance After Intensive Chemotherapy

1997 • 388 citations

Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts.

1996 • 378 citations

Interconversion of CD45R subsets of CD4 T cells in vivo

1990 • 371 citations

Lymphocyte depletion during treatment with intensive chemotherapy for cancer

1994 • 356 citations

Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.

1978 • 353 citations

Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

1989 • 351 citations

Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status.

1994 • 345 citations

Constraints on CD4 Recovery Postchemotherapy in Adults: Thymic Insufficiency and Apoptotic Decline of Expanded Peripheral CD4 Cells

1997 • 334 citations

Lymphocyte depletion during treatment with intensive chemotherapy for cancer

1994 • 314 citations

T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny

1993 • 293 citations

Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse.

1993 • 265 citations

T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life.

1995 • 259 citations

Is T-cell memory maintained by crossreactive stimulation?

1990 • 253 citations

T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny

1993 • 250 citations

T-cell regeneration: all repertoires are not created equal

1997 • 246 citations

Analysis of T-cell repopulation after allogeneic bone marrow transplantation: significant differences between recipients of T-cell depleted and unmanipulated grafts

1996 • 231 citations

Lymphocyte lifespans: homeostasis, selection and competition

1993 • 226 citations

Anergy and exhaustion are independent mechanisms of peripheral T cell tolerance.

1995 • 225 citations

T-cell subpopulations identified by monoclonal antibodies after human marrow transplantation. I. Helper-inducer and cytotoxic-suppressor subsets

1982 • 187 citations

Cyclic regulation of CD45 isoform expression in a long term human CD4+CD45RA+ T cell line.

1991 • 186 citations

Immunological Significance of the Thymus of the Adult Mouse

1962 • 177 citations

The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8⁺ T cell pools

1995 • 174 citations

The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells.

1987 • 173 citations

The extrathymic T-cell development pathway

1992 • 169 citations

Role of the Thymus in Recovery of the Immune Mechanism in the Irradiated Adult Mouse

1963 • 164 citations

Altered representation of naive and memory CD8 T cell subsets in HIV-infected children.

1995 • 160 citations

Expression of Costimulatory Molecule CD28 on T Cells in Human Immunodeficiency Virus Type 1 Infection: Functional and Clinical Correlations

1994 • 156 citations

The effect of thymic function on immunocompetence following bone marrow transplantation.

1995 • 155 citations

Oligoclonal expansion of CD8+ CD57+ T cells with restricted T-cell receptor beta chain variability after bone marrow transplantation

1994 • 141 citations

Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance.

1990 • 135 citations

Progress in bone marrow transplantation

1987 • 134 citations

Loss of normal thymic repertoire selection and persistence of autoreactive T cells in graft vs host disease.

1994 • 128 citations

Treatment of refractory rheumatoid arthritis with a chimeric ANTI‐CD4 monoclonal antibody

1994 • 118 citations

On the immunocompetence of H-2 incompatible irradiation bone marrow chimeras.

1980 • 118 citations

Activation and differentiation requirements of primary T cells in vitro.

1993 • 102 citations

Emergence of oligoclonal t cell populations following therapeutic t cell depletion in rheumatoid arthritis

1995 • 97 citations

Extrathymic maturation of alpha beta T cells from hemopoietic stem cells.

1995 • 90 citations

Reconstitution of T-cell function after CD6-depleted allogeneic bone marrow transplantation

1990 • 79 citations

Recovery of T cell subsets after autologous bone marrow transplantation is mainly due to proliferation of mature T cells in the graft

1985 • 73 citations

Loss of activation-induced CD45RO with maintenance of CD45RA expression during prolonged culture of T cells and NK cells.

1991 • 73 citations

Stable clonal expansion of T cells induced by bone marrow transplantation

1996 • 70 citations

T cell regeneration after allogeneic bone marrow transplantation.

1983 • 69 citations

PATTERN OF T CELL RECONSTITUTION FOLLOWING ALLOGENEIC BONE MARROW TRANSPLANTATION FOR ACUTE HEMATOLOGICAL MALIGNANCY

1982 • 62 citations

Reconstitution of T-cell function after CD6-depleted allogeneic bone marrow transplantation

1990 • 62 citations

Regeneration of functional and activated NK and T sub-subset cells in the marrow and blood after autologous bone marrow transplantation: a prospective phenotypic study with 2/3-color FACS analysis.

1989 • 60 citations

Thymic selection and thymic major histocompatibility complex class II expression are abnormal in mice undergoing graft-versus-host reactions.

1993 • 58 citations

Haploidentical bone marrow stem cell transplantation in human severe combined immunodeficiency.

1993 • 57 citations

The reappearance of 10 differentiation antigens on peripheral blood lymphocytes after allogeneic bone marrow transplantation.

1991 • 57 citations

T lymphocyte ontogeny in adenosine deaminase-deficient severe combined immune deficiency after treatment with polyethylene glycol-modified adenosine deaminase.

1993 • 56 citations

Alterations of T cell repertoire after bone marrow transplantation: characterization of over-represented subsets.

1995 • 45 citations

The thymus in patients with allogeneic bone marrow transplants.

1978 • 44 citations

CD45R CD4 T cell subset‐reconstituted nude rats: subset‐dependent survival of recipients and bi‐directional isoform switching

1991 • 43 citations

Reversal of CD45R isoform switching in CD8+ T cells

1992 • 39 citations

The origin of T cells in permanently reconstituted old athymic nude rats. Analysis using chromosome or allotype markers.

1989 • 23 citations

Fidelity of the repertoire in T cell reconstituted athymic nude rats. Preservation of a deficit in alloresponsiveness over one year.

1989 • 15 citations

Antiviral immune responses of fully allogeneic irradiation bone marrow mouse chimeras.

1991 • 2 citations