Altered peptide ligand design: altering immune responses to class I MHC/peptide complexes

T-cell antigen receptor genes and T-cell recognition

1988 • 3,099 citations

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

1991 • 2,447 citations

Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 Å resolution

1991 • 1,079 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

The antigenic identity of peptide-MHC complexes: A comparison of the conformations of five viral peptides presented by HLA-A2

1993 • 681 citations

The three-dimensional structure of HLA-B27 at 2.1 Å resolution suggests a general mechanism for tight peptide binding to MHC

1992 • 670 citations

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

1985 • 669 citations

Specificity pockets for the side chains of peptide antigens in HLA-Aw68

1989 • 664 citations

Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules

1993 • 630 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

1996 • 613 citations

A Critical Role for Tapasin in the Assembly and Function of Multimeric MHC Class I-TAP Complexes

1997 • 528 citations

A binding site for the T-cell co-receptor CD8 on the α3 domain of HLA-A2

1990 • 527 citations

The natural history of the major histocompatibility complex

1987 • 500 citations

Crystal structure of the complex between human CD8αα and HLA-A2

1997 • 471 citations

Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen.

1991 • 363 citations

Selectivity of MHC-encoded peptide transporters from human, mouse and rat

1994 • 339 citations

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1996 • 326 citations

The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection

1997 • 322 citations

CD28-B7 interactions in T-cell activation

1994 • 315 citations

Importance of Peptide Amino and Carboxyl Termini to the Stability of MHC Class I Molecules

1994 • 294 citations

T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity

1994 • 292 citations

Atomic structure of a human MHC molecule presenting an influenza virus peptide

1992 • 254 citations

Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assays

1994 • 233 citations

Three-dimensional structure of a peptide extending from one end of a class I MHC binding site

1994 • 222 citations

Major antigen-induced domain rearrangements in an antibody

1993 • 206 citations

Bound Water Structure and Polymorphic Amino Acids Act Together to Allow the Binding of Different Peptides to MHC Class I HLA-B53

1996 • 162 citations

Processing and delivery of peptides presented by MHC class I molecules

1996 • 161 citations

A subset of HLA-B27 molecules contains peptides muchlonger than nonamers.

1994 • 161 citations

A Point Mutation in HLA-A*0201 Results in Failure to Bind the TAP Complex and to Present Virus-Derived Peptides to CTL

1996 • 139 citations

Prominence of beta 2-microglobulin, class I heavy chain conformation, and tapasin in the interactions of class I heavy chain with calreticulin and the transporter associated with antigen processing.

1997 • 132 citations

Point mutations in the α2 domain of HLA-A2.1 define a functionally relevant interaction with TAP

1996 • 130 citations

Cloning and functional characterization of a subunit of the transporter associated with antigen processing

1997 • 127 citations

Amino-terminal alteration of the HLA-A*0201-restricted human immunodeficiency virus pol peptide increases complex stability and in vitro immunogenicity.

1995 • 126 citations

Recognition of influenza A matrix protein by HLA-A2-restricted cytotoxic T lymphocytes. Use of analogues to orientate the matrix peptide in the HLA-A2 binding site.

1988 • 121 citations

Comparison of the P2 specificity pocket in three human histocompatibility antigens: HLA-A*6801, HLA-A*0201, and HLA-B*2705.

1993 • 116 citations

The beta 2-microglobulin dissociation rate is an accurate measure of the stability of MHC class I heterotrimers and depends on which peptide is bound.

1992 • 113 citations

Generation, intracellular transport and loading of peptides associated with MHC class I molecules

1997 • 111 citations

Thermodynamic and Structural Compensation in “Size-switch” Core Repacking Variants of Bacteriophage T4 Lysozyme

1996 • 81 citations

The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain.

1995 • 72 citations

Peptide binding by class I and class II MHC molecules

1997 • 70 citations

Interleukin 3 enhances cytotoxic T lymphocyte development and class I major histocompatibility complex "re-presentation" of exogenous antigen by tumor-infiltrating antigen-presenting cells.

1996 • 67 citations

Differences in peptide presentation between B27 subtypes: The importance of the P1 side chain in maintaining high affinity peptide binding to B★2703

1994 • 65 citations

Tolerance to Amino Acid Variations in Peptides Binding to the Major Histocompatibility Complex Class I Protein H-2Kb

1995 • 62 citations

HLA-B^*3501–peptide interactions: role of anchor residues of peptides in their binding to HLA-B^* 3501 molecules

1994 • 53 citations

Allele-specific B pocket transplant in class I major histocompatibility complex protein changes requirement for anchor residue at P2 of peptide.

1993 • 52 citations

The role of charge and multiple faces of the CD8alpha/alpha homodimer in binding to major histocompatibility complex class Imolecules: support for a bivalent model.

1994 • 51 citations

Analysis of mutant HLA-A2 molecules. Differential effects on peptide binding and CTL recognition.

1994 • 46 citations

Effects of Peptide Length and Composition on Binding to an Empty Class I MHC Heterodimer

1994 • 43 citations

Differential contact of disparate class I/peptide complexes as the basis for epitope cross-recognition by a single T cell receptor.

1997 • 37 citations

Synthetic peptide libraries in the determination of T cell epitopes and peptide binding specificity of class I molecules

1992 • 31 citations

Analysis of the Effect of Cytokines (Interleukins 2, 3, 4, and 6, Granulocyte-Monocyte Colony-Stimulating Factor, and Interferon-γ) on Generation of Primary Cytotoxic T Lymphocytes against a Weakly Immunogenic Tumor

1995 • 28 citations

Naturally occurring A pocket polymorphism in HLA-B*2703 increases the dependence on an accessory anchor residue at P1 for optimal binding of nonamer peptides.

1997 • 27 citations

Mechanism of cytolytic T lymphocyte killing of a low class I-expressing tumor.

1991 • 26 citations

Differential role of conserved and polymorphic residues of the binding groove of MHC class I molecules in the selection of peptides.

1993 • 21 citations

The Role of Peptide Specificity in MHC Class I‐Restricted Allogeneic Responses

1996 • 16 citations

Use of synthetic peptide libraries for the H-2Kd binding motif identification.

1995 • 9 citations

Alterations of a dominant epitope of lymphocytic choriomeningitis virus which affect class I binding and cytotoxic T cell recognition

1995 • 2 citations

Extinction With a Whimper

1992 • 2 citations