Susceptibility to type I diabetes: HLA-DQ and DR revisited

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

HL-A ANTIGENS AND DIABETES MELLITUS

1974 • 802 citations

MHC Class-II Molecules and Autoimmunity

1991 • 521 citations

Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

1992 • 494 citations

Histocompatibility (HL-A) Antigens, Lymphocytotoxic Antibodies and Tissue Antibodies in Patients with Diabetes Mellitus

1973 • 409 citations

Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome llq

1994 • 397 citations

Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin-dependent diabetes mellitus.

1988 • 371 citations

A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus.

1990 • 332 citations

Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus.

1992 • 290 citations

A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles.

1989 • 260 citations

Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512).

1995 • 257 citations

Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes

1993 • 247 citations

Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping

1989 • 238 citations

Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to Type 1 (insulin-dependent) diabetes mellitus

1993 • 213 citations

64 000 Mr autoantibodies as predictors of insulin-dependent diabetes

1990 • 208 citations

Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis.

1986 • 193 citations

A Unified Hypothesis for the Complex Genetics of HLA Associations With IDDM

1990 • 190 citations

HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families

1993 • 186 citations

A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus

1994 • 175 citations

HL-A System and Diabetes Mellitus

1975 • 154 citations

Distribution of HLA‐DRB1, ‐DQA1 and ‐DQB1 alleles and DQA1‐DQB1 genotypes among Norwegian patients with insulin‐dependent diabetes mellitus

1991 • 144 citations

Genetic analysis of HLA class II alleles and susceptibility to Type 1 (insulin-dependent) diabetes mellitus in Japanese subjects

1992 • 128 citations

Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in sardinia

1993 • 120 citations

Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27.

1995 • 115 citations

HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation.

1993 • 110 citations

Dose Effect of Cis- and Trans-Encoded HLA-DQαβ Heterodimers in IDDM Susceptibility

1992 • 105 citations

Dose effect of cis- and trans-encoded HLA-DQ alpha beta heterodimers in IDDM susceptibility

1992 • 103 citations

HLA-DQ primarily confers protection and HLA-DR susceptibility in type I (insulin-dependent) diabetes studied in population-based affected families and controls.

1993 • 100 citations

Review Human Th1 and Th2 Cells: Functional Properties, Regulation of Development and Role in Autoimmunity

1994 • 100 citations

The distribution of DR4 haplotypes in sardinia suggests a primary association of type I diabetes with DRB1 and DQB1 loci

1995 • 96 citations

HLA and Insulin-Dependent Diabetes. A protective perspective

1992 • 94 citations

Self peptides isolated from MHC glycoproteins of non-obese diabetic mice.

1994 • 92 citations

Association of LMP2 and LMP7 genes within the major histocompatibility complex with insulin-dependent diabetes mellitus: population and family studies.

1995 • 89 citations

Polymorphic Amino Acid Variations in HLA-DQ Are Associated With Systematic Physical Property Changes and Occurrence of IDDM

1995 • 89 citations

HLA-DQ polymorphisms are highly selective for peptide binding interactions.

1995 • 83 citations

Implication of Specific DQB1 Alleles in Genetic Susceptibility and Resistance by Identification of IDDM Siblings With Novel HLA-DQB1 Allele and Unusual DR2 and DR1 Haplotypes

1991 • 79 citations

DRB1*0403 Protects Against IDDM in Caucasians With the High-Risk Heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 Genotype

1995 • 75 citations

Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of IDDM. Members of the Swedish Childhood Diabetes Study

1995 • 75 citations

A unified hypothesis for the complex genetics of HLA associations with IDDM

1990 • 74 citations

HLA-encoded susceptibility to insulin-dependent diabetes mellitus is determined by DR and DQ genes as well as their linkage disequilibria in a Chinese population

1995 • 71 citations

HLA-DQβ Sequence Polymorphism and Genetic Susceptibility to IDDM

1990 • 70 citations

Association of HLA-DPB1*0301 With IDDM in Mexican-Americans

1996 • 63 citations

HLA-DQA1 and -DQB1 Alleles Associated With Genetic Susceptibility to IDDM in a Black Population

1991 • 58 citations

Primary Association of HLA-DQw8 With Type I Diabetes in DR4 Patients

1989 • 56 citations

HL-A system and diabetes mellitus

1975 • 51 citations

A new marker in the HLA class I region is associated with the age at onset of IDDM

1995 • 50 citations

Susceptibility to IDDM in a Chinese Population: Role of HLA Class II Alleles

1992 • 46 citations

Association of HLA-DQw3 (TA10−) With Type I Diabetes Occurs With DR3/4 but not DR1/4 Patients

1988 • 43 citations

Role of HLA Genes in Predisposition to Develop Insulin-dependent Diabetes Mellitus

1992 • 43 citations

Association of insulin-dependent diabetes mellitus in Taiwan with HLA class II DQB1 and DRB1 alleles

1993 • 42 citations

Distribution of HLA‐DQA1, ‐DQB1 and DRB1 alleles in black IDDM patients and controls from Zimbabwe

1992 • 40 citations

A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus

1995 • 38 citations

Additive Susceptibility to Insulin-Dependent Diabetes Conferred by Hla-Dqb1 and Insulin Genes

1994 • 38 citations

HLA-DQ beta sequence polymorphism and genetic susceptibility to IDDM

1990 • 38 citations

DRB1*0403 protects against IDDM in Caucasians with the high-risk heterozygous DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype. Belgian Diabetes Registry

1995 • 38 citations

HLA-DQA1 and -DQB1 alleles associated with genetic susceptibility to IDDM in a black population

1991 • 35 citations

Genes for insulin‐dependent diabetes mellitus (IDDM) in the major histocompatibility complex (MHC) of African‐Americans

1993 • 34 citations

High frequency of the HLA-DRB1 0405-(Dw15)-DQw8 haplotype in Spaniards and its relationship to diabetes susceptibility

1991 • 34 citations

HLA and insulin-dependent diabetes. A protective perspective

1992 • 33 citations

Association of HLA-DQw3 (TA10-) with type I diabetes occurs with DR3/4 but not DR1/4 patients

1988 • 27 citations

Susceptibility to IDDM in a Chinese population. Role of HLA class II alleles

1992 • 27 citations

Primary association of HLA-DQw8 with type I diabetes in DR4 patients

1989 • 27 citations

Association of HLA-DPB1*0301 with IDDM in Mexican-Americans

1996 • 21 citations

HLA CLASS II POLYMORPHISM AND IDDM SUSCEPTIBILITY IN THE GREEK POPULATION

1993 • 20 citations

High Risk HLA-DR/DQ Genotypes for IDD Confer Susceptibility to Autoantibodies but DQB1*0602 does not Prevent them

1994 • 19 citations

Implication of specific DQB1 alleles in genetic susceptibility and resistance by identification of IDDM siblings with novel HLA-DQB1 allele and unusual DR2 and DR1 haplotypes

1991 • 17 citations

Mouse or Man: Is GAD the cause of type I diabetes?

1994 • 14 citations

A strong association of HLA-DR 3/4 heterozygotes with insulin-dependent diabetes among Chinese in Taiwan.

1988 • 8 citations