Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

γ-AMINOBUTYRIC ACID IN BRAIN: ITS FORMATION FROM GLUTAMIC ACID

1950 • 679 citations

Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

1982 • 531 citations

Functional diversity of T lymphocytes due to secretion of different cytokine patterns

1991 • 530 citations

Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

1992 • 494 citations

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.

1992 • 487 citations

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

1991 • 381 citations

The Distribution of Glutamic Decarboxylase in the Nervous System of the Rhesus Monkey

1959 • 367 citations

Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes

1990 • 356 citations

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes.

1987 • 319 citations

Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10.

1991 • 281 citations

Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes

1992 • 275 citations

High Concentration of GABA and High Glutamate Decarboxylase Activity in Rat Pancreatic Islets and Human Insulinoma

1976 • 235 citations

The Relationship Between Humoral and Cell‐Mediated Immunity

1972 • 228 citations

64 000 Mr autoantibodies as predictors of insulin-dependent diabetes

1990 • 208 citations

Antibodies to Glutamic Acid Decarboxylase Discriminate Major Types of Diabetes Mellitus

1992 • 154 citations

Selective Activation of Th1‐ and Th2‐like Cells in vivo– Response to Human Collagen IV

1991 • 129 citations

Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes.

1993 • 125 citations

Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes.

1993 • 113 citations

Prognostically Significant Heterogeneity of Cytoplasmic Islet Cell Antibodies in Relatives of Patients with Type I Diabetes

1992 • 107 citations

Distinct cytoplasmic islet cell antibodies with different risks for Type 1 (insulin-dependent) diabetes mellitus

1992 • 104 citations

Islet cell antigens in insulin-dependent diabetes: Pandora's box revisited

1992 • 97 citations

Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus.

1991 • 96 citations

Recombinant Glutamic Acid Decarboxylase (Representing the Single Isoform Expressed in Human Islets) Detects IDDM-Associated 64,000-Mr Autoantibodies

1992 • 95 citations

Antibodies to glutamic acid decarboxylase discriminate major types of diabetes mellitus

1992 • 83 citations

Islet-reactive T cells are a marker of preclinical insulin-dependent diabetes.

1992 • 67 citations

Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes.

1992 • 56 citations

HLA-DR3 and -DR4 control T-lymphocyte responses to mumps and Coxsackie B4 virus: studies on patients with Type 1 (insulin-dependent) diabetes and healthy subjects

1985 • 55 citations

Reactivity to Human Islets and Fetal Pig Proislets by Peripheral Blood Mononuclear Cells From Subjects With Preclinical and Clinical Insulin-Dependent Diabetes

1991 • 53 citations

Prognostically significant heterogeneity of cytoplasmic islet cell antibodies in relatives of patients with type I diabetes

1992 • 51 citations

Autoantibodies to glutamic acid decarboxylase (GAD) detected by an immuno-trapping enzyme activity assay: Relation to insulin-dependent diabetes mellitus and islet cell antibodies

1991 • 49 citations

An ELISA for Antibodies to Recombinant Glutamic Acid Decarboxylase in IDDM

1992 • 40 citations

Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64,000-M(r) autoantibodies

1992 • 33 citations

Cloning and partial nucleotide sequence of human glutamic acid decarboxylase cDNA from brain and pancreatic islets

1991 • 31 citations

Reactivity to human islets and fetal pig proislets by peripheral blood mononuclear cells from subjects with preclinical and clinical insulin-dependent diabetes

1991 • 24 citations

The natural history and predictive value of Mr 64,000 autoantibodies for insulin-dependent diabetes mellitus

1990 • 21 citations

Defective autologous mixed leukocyte reaction in newly diagnosed type 1 diabetes mellitus.

1988 • 19 citations

Two distinct HLA-DR3 haplotypes are associated with age related heterogeneity in Type 1 (insulin-dependent) diabetes

1988 • 19 citations

A 64 kDa antigen/glutamic acid decarboxylase (GAD) in fetal pig pro-islets: Co-precipitation with a 38 kDa protein and recognition by T cells in humans at risk for insulin-dependent diabetes

1992 • 18 citations

An ELISA for antibodies to recombinant glutamic acid decarboxylase in IDDM

1992 • 15 citations

Molecular Cloning of Full-Length Glutamic Acid Decarboxylase 67 from Human Pancreas and Islets

1993 • 10 citations