Complement-dependent Clearance of Apoptotic Cells by Human Macrophages

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

1998 • 3,085 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

1989 • 1,540 citations

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

1998 • 1,431 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

T-cell apoptosis detected in situ during positive and negative selection in the thymus

1994 • 1,071 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Structure and function of the leukocyte adhesion molecules CD11/CD18

1990 • 962 citations

Repeat-induced gene silencing in mammals

1998 • 884 citations

Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis

1990 • 871 citations

Structure and function of the leukocyte adhesion molecules CD11/CD18

1990 • 785 citations

Human CD14 mediates recognition and phagocytosis of apoptotic cells

1998 • 685 citations

Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes.

1995 • 675 citations

Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies.

1983 • 674 citations

C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited.

1997 • 661 citations

Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte, and monocyte

1980 • 645 citations

A Novel Role for the β2 Integrin CD11b/CD18 in Neutrophil Apoptosis: A Homeostatic Mechanism in Inflammation

1996 • 645 citations

Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor.

1982 • 615 citations

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

1992 • 605 citations

Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production

1998 • 573 citations

Mechanism of Suppression of Cell-Mediated Immunity by Measles Virus

1996 • 564 citations

Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes.

1983 • 495 citations

Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.

1991 • 463 citations

Macrophage recognition of cells undergoing programmed cell death (apoptosis).

1985 • 460 citations

Membrane complement receptor type three (CR3) has lectin-like properties analogous to bovine conglutinin as functions as a receptor for zymosan and rabbit erythrocytes as well as a receptor for iC3b.

1985 • 433 citations

Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.

1996 • 427 citations

CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis.

1995 • 392 citations

C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180

1998 • 377 citations

Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes.

1980 • 365 citations

Selective Suppression of Interleukin-12 Induction after Macrophage Receptor Ligation

1997 • 363 citations

Phagocytosis of senescent neutrophils by human monocyte-derived macrophages and rabbit inflammatory macrophages.

1982 • 326 citations

CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide.

1995 • 303 citations

Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol).

1983 • 303 citations

Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism.

1989 • 298 citations

The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death.

1996 • 294 citations

Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: role of membrane phosphatidylserine.

1995 • 293 citations

Regulation of Interleukin-12 by Complement Receptor 3 Signaling

1997 • 280 citations

Complement Receptor Type 1 (CR1, CD35) Is a Receptor for C1q

1997 • 257 citations

Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1.

1994 • 247 citations

Roles of histamine, complement and xanthine oxidase in thermal injury of skin.

1989 • 233 citations

A Mini-Surge on the Ryder Glacier, Greenland, Observed by Satellite Radar Interferometry

1996 • 214 citations

Trans-dominant inhibition of integrin function.

1996 • 174 citations

The Alternative Pathway of Complement — A System for Host Resistance to Microbial Infection

1980 • 169 citations

Integrins as promiscuous signal transduction devices

1996 • 165 citations

Dissociation of phagocytosis from stimulation of the oxidative metabolic burst in macrophages.

1984 • 160 citations

Enhancement of macrophage phagocytosis upon iC3b deposition on apoptotic cells

1996 • 158 citations

SRB1, a Class B Scavenger Receptor, Recognizes both Negatively Charged Liposomes and Apoptotic Cells

1996 • 144 citations

Outside-in signaling by lipopolysaccharide through a tailless integrin.

1997 • 130 citations

Ligated complement receptors do not activate the arachidonic acid cascade in resident peritoneal macrophages.

1985 • 128 citations

Recognition of apoptotic cells by human macrophages: inhibition by a monocyte/macrophage‐specific monoclonal antibody

1994 • 118 citations

Time course of complement activation and inhibitor expression after ischemic injury of rat myocardium.

1994 • 112 citations

ROLE OF COMPLEMENT IN HIV INFECTION

1997 • 110 citations

Recognition and clearance of liposomes containing phosphatidylserine are mediated by serum opsonin

1995 • 105 citations

Apoptosis is associated with reduced expression of complement regulatory molecules, adhesion molecules and other receptors on polymorphonuclear leucocytes: functional relevance and role in inflammation.

1995 • 102 citations

Antibody-independent activation of C1, the first component of complement, by cardiolipin.

1985 • 74 citations

Rapid activation of the complement system by cuprophane depends on complement component C4

1998 • 73 citations

Activation of the Alternative Pathway of Human Complement by Apoptotic Human Umbilical Vein Endothelial Cells1

1994 • 60 citations

Complement deposits in epidermal cells after ultraviolet B exposure.

1993 • 25 citations

Defect of a complement receptor 3 epitope in a patient with systemic lupus erythematosus.

1993 • 18 citations

Homologous complement activation on drug-induced apoptotic cells from a human lung adenocarcinoma cell line

1997 • 13 citations

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