Rho-kinase as a Novel Therapeutic Target in Treatment of Cardiovascular Diseases

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Small GTP-Binding Proteins

2001 • 2,449 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase

1998 • 1,034 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.

1996 • 872 citations

Rho–Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells

2001 • 743 citations

A Novel Serine/Threonine Kinase Binding the Ras-related RhoA GTPase Which Translocates the Kinase to Peripheral Membranes

1995 • 711 citations

An essential part for Rho–associated kinase in the transcellular invasion of tumor cells

1999 • 609 citations

Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage

1992 • 432 citations

Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.

2001 • 410 citations

The Small GTPase Rho: Cellular Functions and Signal Transduction

1996 • 404 citations

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

1999 • 312 citations

Possible Involvement of Rho-Kinase in the Pathogenesis of Hypertension in Humans

2001 • 309 citations

Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway

2001 • 304 citations

Chronic treatment with interleukin-1 beta induces coronary intimal lesions and vasospastic responses in pigs in vivo. The role of platelet-derived growth factor.

1996 • 283 citations

Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension

2001 • 281 citations

Human Urotensin II–Induced Contraction and Arterial Smooth Muscle Cell Proliferation Are Mediated by RhoA and Rho-Kinase

2001 • 263 citations

Rho and Rho Kinase Mediate Thrombin-Stimulated Vascular Smooth Muscle Cell DNA Synthesis and Migration

1999 • 260 citations

Remodeling Rather Than Neointimal Formation Explains Luminal Narrowing After Deep Vessel Wall Injury

1996 • 210 citations

Inhibition of Rho-Associated Kinase Results in Suppression of Neointimal Formation of Balloon-Injured Arteries

2000 • 199 citations

Rho-Kinase Is Involved in Macrophage-Mediated Formation of Coronary Vascular Lesions in Pigs In Vivo

2000 • 193 citations

Pitavastatin Enhanced BMP-2 and Osteocalcin Expression by Inhibition of Rho-Associated Kinase in Human Osteoblasts

2001 • 187 citations

Involvement of Rho-Kinase in Angiotensin II–Induced Hypertrophy of Rat Vascular Smooth Muscle Cells

2000 • 177 citations

Rho-Kinase Mediates Angiotensin II-Induced Monocyte Chemoattractant Protein-1 Expression in Rat Vascular Smooth Muscle Cells

2001 • 176 citations

Cytoskeletal Rearrangements and Transcriptional Activation of c-fos Serum Response Element by Rho-kinase

1997 • 176 citations

Role of RhoA and Rho Kinase in Lysophosphatidic Acid–Induced Endothelial Barrier Dysfunction

2000 • 172 citations

Cellular and Molecular Mechanisms of Coronary Artery Spasm

2000 • 171 citations

Cytoskeletal Effects of Rho-Like Small Guanine Nucleotide–Binding Proteins in the Vascular System

2001 • 155 citations

Enhanced Myosin Light Chain Phosphorylations as a Central Mechanism for Coronary Artery Spasm in a Swine Model With Interleukin-1β

1997 • 153 citations

Critical Role of Rho-Kinase and MEK/ERK Pathways for Angiotensin II–Induced Plasminogen Activator Inhibitor Type-1 Gene Expression

2001 • 143 citations

Role of Rho-Associated Kinase in Neointima Formation After Vascular Injury

2001 • 131 citations

Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo

2001 • 106 citations

Adenovirus-Mediated Transfer of Dominant-Negative Rho-Kinase Induces a Regression of Coronary Arteriosclerosis in Pigs In Vivo

2001 • 92 citations

A New Model of Cerebral Microthrombosis in Rats and the Neuroprotective Effect of a Rho-Kinase Inhibitor

2000 • 88 citations

Evaluation of Y-27632, a Rho-kinase inhibitor, as a bronchodilator in guinea pigs

2000 • 79 citations

Wound-induced migration of rat hepatic stellate cells is modulated by endothelin-1 through rho-kinase-mediated alterations in the acto-myosin cytoskeleton

2001 • 72 citations

Enhancement of Rho/Rho-kinase system in regulation of vascular smooth muscle contraction in tachycardia-induced heart failure

2001 • 43 citations

Inhibitory Effects of ML-9, Wortmannin, and Y-27632 on the Chemotaxis of Vascular Smooth Muscle Cells in Response to Platelet-Derived Growth Factor-BB

2000 • 34 citations

The Protein Kinase Inhibitor Fasudil Protects Against Ischemic Myocardial Injury Induced by Endothelin-1 in the Rabbit

2000 • 31 citations

Dose escalation trial of a novel calcium antagonist, AT877, in patients with aneurysmal subarachnoid haemorrhage

1990 • 31 citations

Antiischemic Properties of Fasudil in Experimental Models of Vasospastic Angina

2001 • 30 citations

Suppression of HIV-1 replication in peripheral blood mononuclear cells by fasudil.

1998 • 2 citations